Effects of the polysaccharide fraction of Urtica fissa on castrated rat prostate hyperplasia induced by testosterone propionate

Zhang, Q.; Li, L.; Liu, L.; Li, Y.; Yuan, Liming; Song, L.; Wu, Zhiyong

doi:10.1016/j.phymed.2007.12.005

Cited by 16 publications

(16 citation statements)

References 16 publications

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“…The crude polysaccharides of Semen vaccariae astonishingly showed strong inhibitory activity on BPH by improving the prostatic index, testicular index, and ameliorating pathomorphology. 29 To compare the relevant structural specifications of antrodan vs. the UFP: MW, 442 vs. 4.14 kD; total carbohydrate expressed as total sugar, 14.1% vs. 61.44%; protein, 71.00% vs. 9.10% (as total amino acids); and the constituent monosaccharides, seven types (glucose, xylose, mannose, fucose, galactose, arabinose, and rhamnose) vs. two types (D-glucose and D-arabinose). 29 In addition, the histopathological examination showed that proliferation of prostatic epithelial cells and fibrotic tissues were substantially inhibited by UFP.…”

Section: Discussionmentioning

confidence: 99%

“…28 Treatment with Urtica fissa crude polysaccharide (UFP) at 62.5 mg kg −1 body weight decreased the prostatic volume index by 32%, the wet weight index by 17% and the dry weight index by 23%. 29,31,43,44 Apparently, the repeat unit (or possible linkage) was totally different. 29 To compare the relevant structural specifications of antrodan vs. the UFP: MW, 442 vs. 4.14 kD; total carbohydrate expressed as total sugar, 14.1% vs. 61.44%; protein, 71.00% vs. 9.10% (as total amino acids); and the constituent monosaccharides, seven types (glucose, xylose, mannose, fucose, galactose, arabinose, and rhamnose) vs. two types (D-glucose and D-arabinose).…”

Section: Discussionmentioning

confidence: 99%

“…29 To compare the relevant structural specifications of antrodan vs. the UFP: MW, 442 vs. 4.14 kD; total carbohydrate expressed as total sugar, 14.1% vs. 61.44%; protein, 71.00% vs. 9.10% (as total amino acids); and the constituent monosaccharides, seven types (glucose, xylose, mannose, fucose, galactose, arabinose, and rhamnose) vs. two types (D-glucose and D-arabinose). 29,31,43,44 This fact indicates that the therapeutic effect of a polysaccharide against the specific diseased organ is not closely related with the overall structure; instead it may depend on the specific drug-tissue interaction. Antrodan has a repeat unit of β-glycosylamine linkage of N-acetylglucosamine (GlcNAc) to asparagine (Asn), whereas UFP exhibits a repeat unit of →6)- (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…25 The broth of Agaricus blazei Murill directly inhibited the growth of prostate cancer cells (PCa) via the apoptotic pathway and suppressed PCa growth via antiproliferative and antiandrogenic mechanisms. 29 Only a few places in the literature have cited the biomedicinal effects of the β-glucan occurring in the Antrodia cinnamomea mycelia. 27 The polysaccharides fractionated from Urtica fissa improved BPH by inhibiting the proliferation of prostate epithelial cells and fibrotic tissues.…”

Section: Introductionmentioning

confidence: 99%

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Antrodan, A β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia

et al. 2015

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Benign prostatic hyperplasia (BPH), one of the most common disease usually occurring in men in their 50s, has now become an atypical direct cause of mortality. Currently, phytotherapeutic agents are emerging and are frequently used as a complementary alternative treatment of BPH. β-glucan has shown a diversity of bioactivities involving anticancer, immunomodulatory and anti-inflammatory effects. Antrodia cinnamomea exhibits a diversity of biological activities. Only a few literature references have cited the biomedicinal effects of antrodan, which is a unique β-glucan present in A. cinnamomea mycelia. We hypothesized that antrodan could be beneficial to BPH. Using the Sprague-Dawley rat model, we performed this present experiment. Results indicated that antrodan alleviated most of the pathophysiological manifestations that can be elicited by BPH, by alleviating the prostatic epithelial hyperplasia and collagen deposition, increasing the total cholesterol biosynthesis and conversion into HDL, and suppressing the production of LDL and ROS and the upregulation of IL-1, COX-2 and CD68. Antrodan also effectively suppressed the serum level testosterone and DHT and downregulated aromatase, estradiol and the expression of the androgen receptor. More importantly, antrodan downregulated N-cadherin and vimentin and upregulated E-cadherin, underlying the effective inhibition on the epithelial-mesenchymal transition (EMT). Conclusively, the β-glucan antrodan present in the A. cinamomea mycelia is beneficial to the BPH therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antrodan, A β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia

et al. 2015

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“…The search for improved drugs from natural sources is increasing because natural products may have fewer adverse effects. [10][11][12][13][14][15] Smilax china L., known as ''Ba Qia'' or ''Jin Gang Teng'' in China, has been long used as a traditional Chinese medicine. S. china L. was entered into the Chinese Pharmacopoeia in the 2010 version.…”

Section: Introduction Bmentioning

confidence: 99%

Fraction of Macroporous Resin from Smilax china L. Inhibits Testosterone Propionate–Induced Prostatic Hyperplasia in Castrated Rats

Chen

Xiong²,

Song³

et al. 2012

Journal of Medicinal Food

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The present study was conducted to evaluate the effect of a fraction of macroporous resin (FMR), a bioactive component of Smilax china L., on benign prostatic hyperplasia (BPH) in castrated rats induced by testosterone propionate. Rats were randomly divided into five groups: the negative control group (sham-operated), the model group, two FMR-treated groups (at doses of 300 mg/kg and 600 mg/kg of body weight), and the positive control group (treated with finasteride at the dose of 3 mg/kg). Drugs were administered once a day for three consecutive weeks by gastric gavage. Prostates were weighed, testosterone and dihydrotestosterone (DHT) levels in serum were determined, and histopathological examinations were carried out. FMR treatment inhibited prostatic hyperplasia, reducing the DHT level in serum and improving the prostate gland morphology compared with the model group. The overall results of this study suggest that FMR is effective at inhibiting experimentally induced prostate enlargement, and it presents a valuable resource for the treatment of human BPH.KEY WORDS: benign prostatic hyperplasia dihydrotestosterone fraction of macroporous resin Smilax china L.

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Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

Marrassini

Anesini

2016

Phytother. Res.

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There is a well known link between inflammation and cancer during initiation, propagation and metastasis. Urera aurantiaca (UA) Wedd. (Urticaceae) is a medicinal plant used in traditional medicine to treat inflammatory processes with proven in vivo antiinflammatory and antinociceptive effects. The effects of a methanolic extract (UA) and a purified fraction (PF) on the proliferation of normal and tumoral lymphocytes under the effect of prostaglandin E (PGE ) and on nitric oxide production by lipopolysaccharide-stimulated macrophages was evaluated. Both UA and PF stimulated normal lymphocytes but, in presence of PGE a modulatory effect was observed. The normal lymphocyte proliferation induced by PGE was driven by pathways involving both PKC and H O . In macrophages, UA and PF did not modify cell viability and abrogated the synthesis of nitric oxide induced by lipopolysaccharide. In tumoral lymphocytes, the UA exerted a biphasic effect: at low concentrations it increased cell proliferation, while at high concentrations, it displayed an antiproliferative effect. UA and PF were capable of reverting the proliferative action of PGE . The tumoral cell proliferation induced by PGE is related to PKC, ERK 1/2 and MAP Kinase P38 pathways. The observed effects could be attributed to polyphenols, flavonoids and tannins. This work demonstrates the modulatory effects of the UA on different cell types during inflammatory conditions, which reinforces its antiinflammatory action. Copyright © 2016 John Wiley & Sons, Ltd.

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Effects of the polysaccharide fraction of Urtica fissa on castrated rat prostate hyperplasia induced by testosterone propionate

Cited by 16 publications

References 16 publications

Antrodan, A β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia

Antrodan, A β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia

Fraction of Macroporous Resin from Smilax china L. Inhibits Testosterone Propionate–Induced Prostatic Hyperplasia in Castrated Rats

Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

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