Fraction of Macroporous Resin from <i>Smilax china</i> L. Inhibits Testosterone Propionate–Induced Prostatic Hyperplasia in Castrated Rats

Chen, Jing; Xiong, Chaomei; Song, Shanshan; Han, Pan; Ruan, Jinlan

doi:10.1089/jmf.2011.1968

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Previous studies indicated that testosterone level was not shown to have similar patterns with DHT level. 33,34 Testosterone plays an important role in the development of the male reproductive system. Testosterone level was measured to observe the changes in serum and prostate tissue after TP injection.…”

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confidence: 99%

Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

Kim

Jun

et al. 2020

Journal of Medicinal Food

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Cranberry powder (CR) is reported to be effective against lower urinary tract symptoms (LUTS) and recurrent urinary tract infections. Benign prostatic hyperplasia (BPH) in men older than 50 years is a common cause of LUTS. Here, we attempted to evaluate if CR is also effective for treating BPH using a BPH-induced rat model, which was orally administered CR. Male Sprague-Dawley rats weighing 200-250 g were randomly divided into the following six groups (n = 9): noncastration group; castration group; BPH group; BPH and cranberry for 8-week (CR8W) group; BPH and cranberry for 4-week (CR4W) group; and BPH and saw palmetto group (saw palmetto). Compared with the BPH group, the CR8W group showed a significant decrease in prostate weight (by 33%), dihydrotestosterone (DHT) levels (by 18% in serum and 28% in prostate), 5-alpha reductase levels (18% reduction of type 1 and 35% of type 2), and histological changes. These results indicate that CR could attenuate BPH by inhibiting 5-alpha reductase and by reducing other biomarkers such as prostate weight and DHT levels. Thus, CR may be an effective candidate for the development of a functional food for BPH treatment. IACUC (USW-IACUC-R-2015-004).

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confidence: 99%

Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

Kim

Jun

et al. 2020

Journal of Medicinal Food

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“…Men with severely enlarged prostate suffer from obstructive and irritative symptoms including nocturia, irreversible bladder failure, and greater risk of acute urinary retention, which affect the quality of life [ 3 , 4 ]. Although the pathogenesis of BPH has not been fully elucidated, aetiology is explained in ways of ageing, hormonal alterations, growth factors, and inflammatory cell infiltration [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory and Antioxidant Effects of Kelong‐Capsule on Testosterone‐Induced Benign Prostatic Hyperplasia in Rats

Zhang

Fan

Xie

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Benign prostatic hyperplasia (BPH) is a common disease in the current ageing male population. This research aims to study the effects of Kelong-Capsules (KLC) on testosterone-induced BPH. Thirty rats were randomly divided into normal group, model group, and three treatment groups. Three treatment groups were given KLC (3.6 g/kg), KLC (7.2 g/kg), and finasteride (0.9 mg/kg), respectively, for 28 days after establishing the animal model. The BPH rat models were evaluated by Traditional Chinese Medicine (TCM) symptoms and prostate index (PI). Results indicated that three treatment groups all alleviated the pathological changes of prostate and kidney at different levels. Compared with the model group, the PI of the groups treated with KLC (7.2 g/kg) and finasteride decreased significantly. The expressions of NF-E2 related factor 2 (Nrf-2) and quinine oxidoreductase (NQO1) in the group treated with KLC (3.6 g/kg) increased markedly (p < 0.01). The cyclooxygenase-2 (COX-2) protein expression of the group treated with KLC (7.2 g/kg) was increased (p < 0.01). In conclusion, KLC could obviously inhibit the growth of prostate, and KLC (3.6 g/kg) could promote the expressions of Nrf2 and NQO1.

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“…On the other hand, effect of various herbal medicines on BPH and its associated complications has been reported in various studies (9-11). …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the use of herbal medicines and natural products is increasing because of fewer side effects ( 7 , 8 ). On the other hand, effect of various herbal medicines on BPH and its associated complications has been reported in various studies ( 9 - 11 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial

2016

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Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups. The first group was received oral capsule of P. harmala, the second group was administered tamsulosin with oral P. harmala seed and the third group was received tamsulosin drug and they were evaluated after 4 weeks. Results: The results showed that the difference between mean scores of IPSS was significant after the intervention (P=0.001). Besides, the mean of IPSS in the three groups was significantly different (P=0.001) (the first group 41.9±5.3, the second group 21.0±4.4 ,the third group 16.5±3.7 respectively). However, after the intervention, patients in the second group had the lowest average on most indicators of IPSS but the difference was only significant about urinary frequency, nocturia and intermittency(P<0.05). Conclusion: Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with BPH.

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Fraction of Macroporous Resin from Smilax china L. Inhibits Testosterone Propionate–Induced Prostatic Hyperplasia in Castrated Rats

Cited by 7 publications

References 27 publications

Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

Anti‐Inflammatory and Antioxidant Effects of Kelong‐Capsule on Testosterone‐Induced Benign Prostatic Hyperplasia in Rats

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial

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