Effects of the preoperative administration of Yunnan Baiyao capsules on intraoperative blood loss in bimaxillary orthognathic surgery: A prospective, randomized, double-blind, placebo-controlled study

Tang, Zhi; Wang, X.; Bu, Yi; Li, Z.-L.; Cheng, Liang; Wang, X.-X.

doi:10.1016/j.ijom.2008.12.003

Cited by 41 publications

(26 citation statements)

References 23 publications

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“…33,37 The trial of the Chinese medicine Yunnan Baiyao was well designed and the methods properly accounted for; however, the exact ingredients of the drug remain a company secret, and the pharmacokinetics are unclear. 29 These factors should be disclosed in full before any future trials of this product. Also, several well-designed clinical trials investigating various surgical techniques to reduce IOB, including the use of piezo equipment, were excluded because of the obvious absence of operator blinding, exemplifying that it is not always possible or appropriate to conduct an RCT.…”

Section: Discussionmentioning

confidence: 99%

“…29 One study examined the hemostatic effect of mandibular nerve blockage using ropivacaine (without a vasoconstrictor), 25 and HA was investigated in two studies. 26,27 Of the 11 high-quality RCTs, the 6 TXA studies were included in the meta-analysis.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…These methods reduced bleeding by 52% and 21%, respectively (473 AE 190 vs 986 AE 356 Q2 , P = .0003; and 330.5 AE 134.4 vs 420.3 AE 175.9, P = .009). 27,29 Two studies had included HA as a part of the main predictive variable. 22,24 Rossi et al 24 examined 2 types of hypotensive anesthetic methods and found the use of remifentanil and desflurane as a part of a balanced HA, in contrast to the combination of remifentanil and sevoflurane, reduced IOB by approximately 25% (7.2 AE 2.8 vs 9.6 AE 3.7 mL/kg, P < .038).…”

Section: Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Olsen

Skov

Ingerslev

et al. 2016

Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

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Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Olsen

Skov

Ingerslev

et al. 2016

Journal of Oral and Maxillofacial Surgery

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“…Yuannan Baiyao is a Chinese remedy clinically used for stopping bleeding from surgery [6], diseasessuch as advanced cancer and ulcer [7,8] and combat trauma [9]. It has been administered both topically and orally.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Hemostatic Agents Using Thrombelastography

Peng¹

2016

Mater. Sci. Eng. Adv. Res

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Hemorrhage is one of the leading causes of death in civilian and military trauma. Thrombelastography (TEG) quantitatively measures the viscoelastic changes of whole blood during clotting, from the beginning of coagulation to the end with fibrinolysis. In this study, we successfully developedand used a TEG method to compare a well-known Chinese herb medicine (i.e., Yunnan Baiyao) for hemorrhage control with other commercial hemostatic products (e.g., Celox TM and QuikClot TM ) and chitosan in the form of dry powder or dispersion. When tested in the powder form, the herbal material outperformed Celox TM as indicated by all three TEG parameters (i.e., reaction time R, clot formation rate α and maximum clot strength MA), and was comparable with QuikClot TM , but showed no exothermic effects. When tested in the dispersion form, which may be easier to use (as a spray) than in the powder form, the herbal material provided better hemostasis than the other materials, where the coagulation actions of the latter were reduced in the dispersion form. In addition, comparison among Celox TM and various types of chitosan showed the effects of physical and chemical properties of the chitosan-based biomaterials on hemostasis. The hemostatic mechanisms of these agents and their potential benefitsas an inexpensive, safe, and easily available material for hemorrhage control are discussed.

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“…Yunnan Baiyao is a well-known traditional Chinese medicine, formulated in a powder or capsule form. It was initially and widely used in wounds for its antihemorrhagic hemostatic function [7, 8] and further in gastrointestinal bleeding. Yunnan Baiyao powder has been generally applied on RAS among Chinese population [9].…”

Section: Introductionmentioning

confidence: 99%

Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis

Liu

Guan

Chen

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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The study was designed to evaluate the efficacy and safety of an herbal extract of Yunnan Baiyao formulated in toothpaste as an alternative therapy for minor RAS. A randomized, double-blind, placebo-controlled clinical trial (from March 2010 to March 2011) was conducted on a cohort of 227 minor RAS patients. The toothpaste containing Yunnan Baiyao was used twice daily as part of the patient's routine oral hygiene for 5 days. An assessment of ulcerative size and pain was recorded on day 0 (baseline), day 3, and day 5. Any noted adverse reactions were recorded. All data were analyzed using the SAS software 8.0. As a result, the toothpaste containing Yunnan Baiyao began to present noticeable effectiveness on ulcer healing (ulcer size) by day 3 (27.5% versus 15.8%, P < 0.05), which further improved by day 5 when compared to the placebo (66.4% versus 50.0%, P = 0.01). A significant difference in alleviating pain was noted on day 5 for those who used the toothpaste containing Yunnan Baiyao (66.4% versus 51.8%, P < 0.05). No side effects were noted as a result of the Yunnan Baiyao. Therefore, Yunnan Baiyao may provide an alternative therapy for minor ulcers by promoting healing.

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Effects of the preoperative administration of Yunnan Baiyao capsules on intraoperative blood loss in bimaxillary orthognathic surgery: A prospective, randomized, double-blind, placebo-controlled study

Cited by 41 publications

References 23 publications

Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Comparative Study of Hemostatic Agents Using Thrombelastography

Repurposing of Yunnan Baiyao as an Alternative Therapy for Minor Recurrent Aphthous Stomatitis

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