Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid

He, Guannan; Wong, Annie B. H.; Tan, Reginald B. H.

doi:10.1016/j.jcrysgro.2010.11.105

Cited by 17 publications

(12 citation statements)

References 31 publications

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“…23 β-Glycine is thermodynamically the least stable polymorph of glycine, and the formation of this metastable polymorph from the liquid phase is more favorable at the higher rate of supersaturation generation and nucleation. 24 Therefore, rapid crystallization should result in the formation of the β-phase. 25 In glycine/chitosan solution casted on the substrate, evaporation enables the supersaturation condition and subsequently the nucleation.…”

Section: Resultsmentioning

confidence: 99%

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Graphene Based Low Voltage Field Effect Transistor Coupled with Biodegradable Piezoelectric Material Based Dynamic Pressure Sensor

Yogeswaran

Hosseini

Dahiya

2020

ACS Appl. Mater. Interfaces

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Pressure sensors form the basic building block for realisation of an electronic or tactile skin used in prothesis, robotics and other similar applications. This paper presents a device consisting of biodegradable piezoelectric material based dynamic pressure sensor coupled with a graphene field-effect-transistor (GFET) operated at very low voltage (50mV).The device has a biodegradable β-glycine/chitosan composite based metal-insulator-metal (MIM) structure connected with GFET in an extended gate configuration. The developed device shows a sensitivity of 2.70 × 10 -4 kPa -1 for a pressure range of 5 -20 kPa and 7.56 × 10 -4 kPa -1 for a pressure range between 20-35 kPa. A distinctive feature of the presented device is its very low operation voltage, which offers a significant advantage towards the development of energy efficient large-area electronic skin. Further, the biodegradability of piezoelectric material makes presented sensors useful in terms of reduced electronic waste, which is current another growing area of interest.

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Section: Resultsmentioning

confidence: 99%

“…β-glycine is thermodynamically the least stable polymorph of glycine and the formation of this metastable polymorph from the liquid phase is more favourable at the higher rate of supersaturation generation and nucleation 24 . Therefore rapid crystallization should result in the formation of β-phase 25 .…”

Section: Glycine/chitosan Film Characterisationmentioning

confidence: 99%

Graphene Based Low Voltage Field Effect Transistor Coupled with Biodegradable Piezoelectric Material Based Dynamic Pressure Sensor

Yogeswaran

Hosseini

Dahiya

2020

ACS Appl. Mater. Interfaces

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“…Supersaturation is a thermodynamic parameter that stimulates the crystallization process and greatly influences the kinetics of crystal growth and its polymorphic nucleation. [25][26][27][28][29] In general, during the swift cooling process, the superheated experimental solution was swiftly cooled to different low temperatures. Hence, this low temperature condition would be favorable for the generation of various initial supersaturation levels in the solution.…”

Section: Resultsmentioning

confidence: 99%

Polymorphic Control of α and βdl‐Methionine through Swift Cooling Crystallization Process

Suresh

Srinivasan

2021

Crystal Research and Technology

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Polymorphic control and crystal nucleation of and polymorphs of dl-methionine, an essential amino-acid, is attained from saturated aqueous solution through swift cooling crystallization process by generating wide range of supersaturation (0.02 < < 2.19) in the temperature range of 323-274 K. The type of nucleation is very much supersaturation dependent: while lower supersaturation range (0.02 < < 0.08) prefers the stable form, higher supersaturation range (1.20 < < 2.19) yields metastable form. In situ optical microscopy and X-ray diffraction analyses confirm the morphological and structural distinction of the grown polymorphs.

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“…The supersaturation determines the polymorphs in the nucleation of CBZ, as higher supersaturation usually leads to metastable polymorphs, which is consistent with Ostwald's rule and as observed for several other systems. For L-histidine, 25 eflucimibe, 26 L-glutamic acid, 27 carbamazepine, 2,28 m-hydroxybenzoic acid and o-aminobenzoic acid, 29 the metastable polymorph nucleated at high supersaturation, and the stable polymorph at low supersaturation. When foreign surfaces were introduced to the solutions, the percentage of polymorph outcome dramatically changed.…”

Section: Resultsmentioning

confidence: 99%

Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

et al. 2017

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Surface-induced nucleation of carbamazepine (CBZ) in ethanol was investigated with different surface materials: glass, polytetrafluoroethylene (PTFE) and tin. The introduction of foreign surfaces with different areas and surface chemistries into the solution has an impact on the crystal morphology and polymorphic form (Form II or III). With an increase in supersaturation, a higher possibility of crystallisation of CBZ metastable Form II was observed, as expected. Increasing the number of inserts resulted in a direct increase in the surface area available for heterogeneous nucleation. The increase in surface area resulted in the greater possibility of obtaining the metastable Form II of CBZ. The stable Form III preferred to nucleate on tin rather than on glass and PTFE. The results indicate that the two different polymorphs of CBZ can be selectively crystallised out from solution with the aid of a foreign surface. The kinetic mechanism of heterogeneous nucleation of the different polymorphs induced by foreign surfaces was discussed. The potential applications will be used to control and design the crystallisation process.

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Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid

Cited by 17 publications

References 31 publications

Graphene Based Low Voltage Field Effect Transistor Coupled with Biodegradable Piezoelectric Material Based Dynamic Pressure Sensor

Graphene Based Low Voltage Field Effect Transistor Coupled with Biodegradable Piezoelectric Material Based Dynamic Pressure Sensor

Polymorphic Control of α and βdl‐Methionine through Swift Cooling Crystallization Process

Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

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