Effects of the Serotonin-Receptor Agonist Sumatriptan on Postdural Puncture Headache

Carp, H.; Singh, P. J.; Vadhera, Rakesh; Jayaram, A.

doi:10.1213/00000539-199407000-00034

Cited by 61 publications

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“…A review of previous researches points to results similar to those achieved in our study. Various previous studies have pointed to the positive prophylactic effects of dexamethasone and ondansetron on post-spinal anesthesia headache and they could reduce the rate of this headache (2,3,4,(15)(16)(17)(18)(19). Some papers have pointed to dexamethasone's therapeutic effects in controlling headaches caused by spinal anesthesia (4,6,(20)(21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Comparing the prophylactic effect of ondansetron and dexamethasone in controlling headaches caused by spinal anesthesia among women candidated for caesarean A randomized controlled trial

et al. 2018

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Introduction:Spinal anesthesia is one of the most popular methods of anesthesia for caesarean. One of the major side effects of this method is the headache that the patients would experience as a result of spinal anesthesia. Ondansetron and dexamethasone have been reported to be very useful in reducing these headaches. The present research seeks to study the effects of these two types of medicine in reducing the headaches caused by spinal anesthesia among women candidated for caesarean. Materials and Methods: This is a double-blind clinical trial conducted on 120 mothers candidated for elective, second time caesarean. They were divided into the following groups with 40 participants in each one: dexamethasone, ondansetron, and placebo. 8 milligram of IV dexamethasone was used for the first group, while the second group was given 8 milligram of IV ondansetron, and the third group was given the same amount of IV distilled water. After the operation, patients' pain scores were measured at 12, 24, and 48 hours following the operation and the average amount of painkiller used 24 hours after the operation was recorded. SPSS 19 was used to analyze the data. Results: A significant difference was observed between the three groups in terms of the frequency of post-spinal anesthesia headache. This frequency was significantly higher in placebo group compared to what was observed in the other two groups (P = 0.01). Conclusion: Finally, it turned out that both dexamethasone and ondansetron are very effective in reducing headaches caused by spinal anesthesia. Statistics show that dexamethasone is much better and more effective than ondansetron.

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Section: Discussionmentioning

confidence: 99%

Comparing the prophylactic effect of ondansetron and dexamethasone in controlling headaches caused by spinal anesthesia among women candidated for caesarean A randomized controlled trial

et al. 2018

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“…Epidural Hartmann's solution, epidural dextran and saline has been reported to reduce PDPH 6 .it has been suggested that placement of a spinal catheter( through the accidental dural perforation with a Tuohy needle), may provoke an inflammatory reaction which that will seal the hole. 7 Caffeine, sumatriptapan and theophylline has been shown to beneficial in relieving PDPH by cerebral vasoconstriction effect [8][9][10] .Another non invasive method to treat PDPH are bed rest, hydration ,abdominal binder, analgesics, and oral Gabapentine 400mg 11 tid has been reported to relieves pain within 24 hrs.. It is possible that postdural puncture headache left untreated may be complicated by the development of subdural hematoma.…”

Section: Discussion-mentioning

confidence: 99%

Atypical presentations of tuberculous meningitis patient on prolong mechanical ventilation: - A CASE REPORT

Paswan¹

2012

iosrphr

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-Tracheal stenosis is the most common late airway complication of post intubation/trachestomy resulted in hemodynamic deterioration and impairment of respiratory system mechanics. Post-dural puncture headache (PDPH) is well known complication of introduction of spinal/epidural needle in subarachanoid space. In this article, we present a very rare case report of a patient 18 year old male, diagnosis tuberculous meningitis(TBM) get prolong mechanical ventilation and dural puncture had developed tracheal stenosis and post-dural puncture headache . We describe a patient with PDPH and tracheal stenosis which was initially misdiagnosed as simple headache and asthma after prolonged tracheal intubation. Surgery is lifesaving for patients with critical tracheal stenosis, but how to ensure effective gas exchange is crucial to the anesthetic management. KEY WORD:-TBM .PDPH .TRACHEAL STENOSIS CASE HISTORY:-A 18 year-old male who presented with a 6-week history of headache and fever and a 8-hour history of inability to speak and alteration in level of consciousness. There was history of neck pain, occasional nausea /vomiting and no neck stiffness .He had no other remarkable past history of medical and surgical illness. Before presentation, he had been kept on various intravenous antibiotics in private hospitals, with no clinical improvement. Physical examination showed a young man in an altered level of consciousness with signs of meningeal irritation and had left spastic hemiparesis. The patient had progressive respiratory distress with rapid shallow breathing, while using all accessory muscles of respiration. He had a respiratory rate of 35 breaths min -1 , and a fluctuating arterial oxygen saturation of 70~80% with 10 L.min -1 of supplementary oxygen. The patient was ventilated with the synchronized intermittent mandatory ventilation with volume controlled mode selected. The ventilatory settings were as follows: FiO 2 0.40; respiratory rate 14 breaths/min; Tidal volume500ml; pressure support 12 cm H 2 O; positive end expiratory pressure (PEEP) 5 cm H 2 O.With above mentioned settings, the peak airway pressure (PIP) was 16 cm H 2 O, and the arterial blood gas parameters were satisfactory .A lumbar puncture was performed with 23 G spinal needle and produced opalescent cerebrospinal fluid (CSF) with CSF pressure of 14 cm of H20. The biochemical/microbiological features of CSF are :-Protein 80mg/dl; glucose 40mg/dl; WBC 75 /micro L, chiefly there was Lymphocyte (70%)and CSF acid fast and grams staining were negative . CSF culture was not sent .The computed tomography scan of brain showed obstructive hydrocephalus. These above mentioned feature was suggestive of tuberculous meningitis .He was placed immediate on antituberculous drugs and intravenous steroids and mannitol .He was successfully weaned off mechanical ventilatory support after 10 days. After first day of weaning patient experienced of headache and vertigo. Intensivist assumed that headache and vertigo is a part of TBM and symptoms will subside after few da...

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“…• Sumatriptano: é usado para o tratamento da enxaqueca por provocar vasoconstrição cerebral. Seu uso com sucesso na CPPD tem sido relatado por vários autores, tendo a grande vantagem de não ser invasivo [38][39][40][41] . A lógica de seu uso baseia-se na teoria da vasodilatação cerebral reflexa como componente fisiopatológico da CPPD 42 .…”

Section: Discussionunclassified

“…Its efficacy in treating PDPH has been reported by several authors and its major advantage is to be non-invasive [38][39][40][41] . Its logic is based on the reflex cerebral vasodilation as a pathophysiological component of PDPH 42 .…”

Section: Discussionmentioning

confidence: 99%

Tampão peridural com dextran 40 na profilaxia da cefaléia pós-punção acidental da duramáter em paciente HIV positivo: relato de caso

Cruvinel¹,

Barbosa²,

Teixeira³

et al. 2002

Rev. Bras. Anestesiol.

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RESUMO Relato do Caso -Paciente masculino, 31 anos, 70 kg, estado f í s i c o A S A I I , p o r ta d o r d e H I V, pa r a t r a ta m e n t o d e condilomatose anal recidivada, com relato de cefaléia intensa e l i m i ta n t e d u r a n t e d u a s s e m a n a s a p ó s a n e s t e s i a subaracnóidea (agulha Quincke 25G S A I I , H I V p o s i t i v e , p r e s e n t e d f o r r e c u r r e n t a n a l

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Effects of the Serotonin-Receptor Agonist Sumatriptan on Postdural Puncture Headache

Cited by 61 publications

References 0 publications

Comparing the prophylactic effect of ondansetron and dexamethasone in controlling headaches caused by spinal anesthesia among women candidated for caesarean A randomized controlled trial

Comparing the prophylactic effect of ondansetron and dexamethasone in controlling headaches caused by spinal anesthesia among women candidated for caesarean A randomized controlled trial

Atypical presentations of tuberculous meningitis patient on prolong mechanical ventilation: - A CASE REPORT

Tampão peridural com dextran 40 na profilaxia da cefaléia pós-punção acidental da duramáter em paciente HIV positivo: relato de caso

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