Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

Batra, Vinita; Syed, Zanobia; Gill, Jennifer; Coburn, Malari; Adegboyega, Patrick A.; DiGiovanni, John; Mathis, J. Michael; Shi, Runhua; Clifford, John L.; Kleiner-Hancock, Heather E

doi:10.1186/1756-9966-31-57

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…Ichikawa et al reported that ACA enhances apoptosis and inhibits invasion by blocking NF-B activation using different agents and numerous human cell lines 12 . Batra et al indicated that ACA inhibits skin tumorigenesis in constitutive Stat3 expressed transgenic mice (K5.Stat3C) by suppressing NF-B activation 13 . Moreover, Ito et al revealed that ACA upregulates the expression of tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand (TRAIL/Apo2L) and TRAIL receptor death receptor 5 in the apoptotic pathway of human myeloma cells 14 .…”

Section: Anticancer Effects Of Acamentioning

confidence: 99%

Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes ofAlpinia galangaandAlpinia conchigera

Kojima‐Yuasa

Matsui‐Yuasa

2020

Journal of Medicinal Food

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1'-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of Alpinia galanga and Alpinia conchigera, which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, anti-obesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observed to exhibit antidementia activity. Recent studies have demonstrated that combining ACA with other substances results in synergistic anticancer effects. The structural factors which regulates the activity of ACA include: (1) the acetyl group at position 1', (2) the acetyl group at position 4, and (3) the unsaturated double bond between positions 2' and 3'. ACA induces the activation of AMPK, which regulates the signal transduction pathways, and has an important role for the prevention of diseases, including cancer, obesity, hyperlipidemia, diabetes, and neurodegenerative disorders. Such findings suggest that AMPK has a central role in different pharmacological functions of ACA, and ACA is useful for the prevention of life-threatening diseases. However, more studies should be performed to evaluate the clinical effects of ACA and to better understand its potential.

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Section: Anticancer Effects Of Acamentioning

confidence: 99%

Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes ofAlpinia galangaandAlpinia conchigera

Kojima‐Yuasa

Matsui‐Yuasa

2020

Journal of Medicinal Food

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“…This animal model was used to topically administer 12-O-tetra-decanoylphorbol-13-acetate (TPA) to the dorsal skin resulting in psoriasiform skin lesions that closely resemble psoriatic patients. These findings are crucial factors in the development of psoriasis ( Vinita et al, 2012 ). STAT3 is not only a critical factor for T lymphocyte differentiation, but serves as an essential factor in keratinocyte hyperplasia ( Calautti, Avalle & Poli, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model

Xie

Zhang

Lin

et al. 2023

PeerJ

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Background Psoriasis is an autoimmune skin disease characterized by immunocyte activation, excessive proliferation, and abnormal differentiation of keratinocytes. Signal transducers and activators of transcription 3 (STAT3) play a crucial role in linking activated keratinocytes and immunocytes during psoriasis development. T helper (Th) 17 cells and secreted interleukin (IL)-17A contribute to its pathogenesis. IL-17A treated STAT3 overexpressing mouse model might serve as an animal model for psoriasis. Methods In this study, we established a mouse model of psoriasiform dermatitis by intradermal IL-17A injection in STAT3 overexpressing mice. Transcriptome analyses were performed on the skin of wild type (WT), STAT3, and IL-17A treated STAT3 mice. Bioinformatics-based functional enrichment analysis was conducted to predict biological pathways. Meanwhile, the morphological and pathological features of skin lesions were observed, and the DEGs were verified by qPCR. Results IL-17A treated STAT3 mice skin lesions displayed the pathological features of hyperkeratosis and parakeratosis. The DEGs between IL-17A treated STAT3 mice and WT mice were highly consistent with those observed in psoriasis patients, including S100A8, S100A9, Sprr2, and LCE. Gene ontology (GO) analysis of the core DEGs revealed a robust immune response, chemotaxis, and cornified envelope, et al. The major KEGG enrichment pathways included IL-17 and Toll-like receptor signaling pathways. Conclusion IL-17A exacerbates psoriasis dermatitis in a STAT3 overexpressing mouse.

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“…To date, numerous pharmacological properties of ACA have been reported, including anti-tumor, anti-obesity, anti-allergy, anti-microbial, anti-diabetic, gastroprotective, and anti-inflammatory [ 13 , 14 , 15 , 16 ]. In particular, the inhibitory effect of ACA on carcinogenesis has been demonstrated in several animal models of various tumor types, including colon, liver, esophageal, skin, and prostate cancers [ 17 , 18 , 19 , 20 , 21 ]. Moreover, ACA has been shown to induce apoptosis and cell cycle arrest and inhibit angiogenesis and invasion in several cancer cell lines [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

1′-Acetoxyeugenol Acetate Isolated from Thai Ginger Induces Apoptosis in Human Ovarian Cancer Cells by ROS Production via NADPH Oxidase

et al. 2022

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The rhizomes of Alpinia galanga (Thai ginger) have been used extensively as a spice in Southeast Asian and Arabian cuisines and reported to possess a wide range of biological properties, such as antioxidant, antimicrobial, and antibacterial. However, the specific molecular and cellular mechanisms underlying the anti-tumor effects induced by Thai ginger and its corresponding active compounds have been poorly characterized. We found that upon EtOH extraction, Thai ginger extract exhibits cytotoxic activity (IC50 < 10 μg/mL) and triggers cell death via caspase-dependent apoptosis in human ovarian cancer cells. Among the three major compounds isolated from the extract, 1′-acetoxyeugenol acetate (AEA) exhibited potent cytotoxic activity in human ovarian cancer cells, SKOV3 and A2780. AEA induced apoptotic cell death through the activation of caspases-3 and -9. Notably, AEA enhanced the intracellular levels of reactive oxygen species (ROS), and the application of an antioxidant markedly reversed AEA-induced apoptosis of ovarian cancer cells. The knockdown of p47phox, a subunit of NADPH oxidase, suppressed both the pro-apoptotic and ROS-inducing effects of AEA. Additionally, the activation of the mitogen-activated protein kinase (MAPK) pathway by AEA through ROS regulation was found to be involved in AEA-induced apoptosis. Altogether, these results suggest that AEA exhibits potent apoptosis-inducing activity through the activation of the intrinsic pathway via ROS-mediated MAPK signaling in human ovarian cancer cells.

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Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

Cited by 10 publications

References 41 publications

Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes ofAlpinia galangaandAlpinia conchigera

Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes ofAlpinia galangaandAlpinia conchigera

IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model

1′-Acetoxyeugenol Acetate Isolated from Thai Ginger Induces Apoptosis in Human Ovarian Cancer Cells by ROS Production via NADPH Oxidase

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