2007
DOI: 10.1016/j.taap.2007.08.004
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Effects of the UV filter benzophenone-2 on reproduction in fish

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Cited by 164 publications
(70 citation statements)
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“…The 48 h EC 50 of 2,4-dihydroxy-BP on Acarti tonsa was 2.6 mg/L (Kusk et al, 2011), whereas the 72 h IC 10 of 2-hydroxy-4-methoxy-BP on Demodesmus subspicatus was 0.56 mg/L (Sieratowicz et al, 2011). Currently, estrogenic activities (Schlumpf et al, 2004;Suzuki et al, 2005) and developmental effects (Weisbrod et al, 2007) of BP-type UV filters were focused on 4,4-dihydroxy-BP, 2,4-dihydroxy-BP and 2,2′,4,4′-tetrahydroxy-BP, which exhibited estrogenic and additional hormonal activities in vitro . Estrogenicity was displayed by 2-hydroxy-4-methoxy-BP in the MCF-7 breast cancer cell assay and in an immature rat uterotrophic assay.…”
Section: Introductionmentioning
confidence: 97%
“…The 48 h EC 50 of 2,4-dihydroxy-BP on Acarti tonsa was 2.6 mg/L (Kusk et al, 2011), whereas the 72 h IC 10 of 2-hydroxy-4-methoxy-BP on Demodesmus subspicatus was 0.56 mg/L (Sieratowicz et al, 2011). Currently, estrogenic activities (Schlumpf et al, 2004;Suzuki et al, 2005) and developmental effects (Weisbrod et al, 2007) of BP-type UV filters were focused on 4,4-dihydroxy-BP, 2,4-dihydroxy-BP and 2,2′,4,4′-tetrahydroxy-BP, which exhibited estrogenic and additional hormonal activities in vitro . Estrogenicity was displayed by 2-hydroxy-4-methoxy-BP in the MCF-7 breast cancer cell assay and in an immature rat uterotrophic assay.…”
Section: Introductionmentioning
confidence: 97%
“…The reason why these compounds are under scope is related to their toxicity and adverse effects like the known estrogenic effects on biota and humans (Schlumpf et al, 2004;Bester, 2007;Weisbrod et al, 2007;Sieratowicz et al, 2011;Kaiser et al, 2012;Paredes et al, 2014). These effects have already been systematically described by Díaz-Cruz and Barceló (2009) and they include estrogenic activities in vitro , maximum effects on cell proliferation by EMC, ODP, 4-MBC and HMS (Ciszmas et al, 2008), induction of transcriptional activation of human estrogenic receptor α (hERα) and β (hERβ) by BP3, BMDM, EMC, ODP, 4-MBC and HMS (Schreurs et al, 2002).…”
Section: Toxicity and Legislationmentioning
confidence: 99%
“…Compounds 4-MBC and EMC, identified as 'endocrine disruptor compounds' (EDCs) are usually compared to estradiol-17β (E2) a chemical that like UV-filters was found to negatively affect reproduction and sometimes detected at environmentally relevant concentrations (Weisbrod et al, 2007).…”
Section: Toxicity and Legislationmentioning
confidence: 99%
“…For example, in female fathead minnows exposed to the aromatase inhibitor fadrozole for 21 d there was a significant reduction in histologically determined ovarian stage, and reduced vitellogenin uptake into developing oocytes (Ankley et al, 2002). Jensen et al (2004) reported increased numbers of early stage follicles and atretic follicles in female fathead minnows exposed to the anti-androgen flutamide for 21 d. Weisbrod et al (2007) reported increased numbers of previtellogenic oocytes and decreased proportions of early and late vitellogenic oocytes in female fathead minnows exposed to >1.2 mg benzophenone-2/L or to 50 ng 17␣-ethynylestradiol for 15 d. Similar types of effects have been observed in zebrafish and medaka (Kiparissis et al, 2003;van der Ven et al, 2003). Such shifts in the relative proportions of differently staged follicles may reflect effects of the chemicals on the fish reproductive axis, and at the same time obscure aspects of the transcript profile that could yield mechanistic insights.…”
Section: Introductionmentioning
confidence: 99%