Effects of Therapy With Lansoprazole on Intestinal Permeability and Inflammation in Young Cystic Fibrosis Patients

Hendriks, Hanneke; Kreel, B. van; Forget, Patricia

doi:10.1097/00005176-200109000-00006

Cited by 29 publications

(18 citation statements)

References 31 publications

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“…The terminal ileum and proximal colon of neonatal CF mice have increased tissue permeability as indicated by a 30 -40% decrease in tissue resistance measured in a Ussing chamber (19). Increased intestinal permeability is a characteristic of human CF (22) but the cause of this has not been determined, and it may be that mast cell products are involved.…”

Section: Discussionmentioning

confidence: 99%

Inflammation of the cystic fibrosis mouse small intestine

Norkina¹,

Kaur²,

Ziemer³

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

143

188

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The CFTR null mouse [cystic fibrosis (CF) mouse] has a severe intestinal phenotype that serves as a model for CF-related growth deficiency, meconium ileus, and distal intestinal obstructive syndrome. DNA microarray analysis was used to investigate gene expression in the CF mouse small intestine. Sixty-one genes exhibited a statistically significant twofold or greater increase in expression, and 98 genes were downregulated twofold or greater. Of the upregulated genes, most were associated with inflammation and included markers for cells of the innate immune system (mast cells and neutrophils) and for acute-phase genes (serum amyloid A and complement factors). The downregulated genes include 10 cytochrome P-450 genes; several are involved in lipid metabolism, and several are involved in various transport processes. Confirmation by quantitative RT-PCR showed gene expression was significantly increased for mast cell protease 2 (27-fold), hematopoietic cell transcript 1 (17-fold), serum amyloid A3 (2.9-fold), suppressor of cytokine signaling 3 (2.0-fold), leucine-rich α2-glycoprotein (21-fold), resistin-like molecule-β (49-fold), and Muclin (2.5-fold) and was significantly decreased for cytochrome P-450 4a10 (28-fold) and cubilin (114-fold). Immune cell infiltration was confirmed histologically by staining for mast cells and neutrophils. These data demonstrate that the CF intestine exhibits an inflammatory state with upregulation of components of the innate immune system.

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Section: Discussionmentioning

confidence: 99%

Inflammation of the cystic fibrosis mouse small intestine

Norkina¹,

Kaur²,

Ziemer³

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

143

188

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“…Hendriks i wsp. [10] wykazali zwiększoną przepuszczalność błony śluzowej jelita cienkiego oraz występowanie jej stanu zapalnego. Zastosowanie inhibitorów pompy protonowej doprowadziło do częściowej korekty obserwowanych zaburzeń.…”

Section: Dyskusjaunclassified

Early intestinal manifestation in infants with cystic fibrosis – a pilot study

Lisowska¹,

Walkowiak²

2010

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StreszczenieWprowadzenie: Mukowiscydoza (cystic fibrosis -CF) jest chorobą zapalno-destrukcyjną o różnorodnej ekspresji klinicznej. W dotychczas przeprowadzonych badaniach wykazano występowanie procesu zapalnego jelit u chorych na CF, jednak dostępne są wyłącznie wyniki uzyskane u dzieci w wieku przedszkolnym i szkolnym oraz młodych dorosłych. Nie ma natomiast jakichkolwiek danych dotyczących momentu pojawienia się zapalenia jelit u dzieci najmłod-szych. Z tego też względu w publikacji dokonano oceny występowania stanu zapalnego jelit w chwili ustalania rozpoznania u niemowląt diagnozowanych w badaniach przesiewowych noworodków. Materiał i metody: Do badań włączono 10 niemowląt z CF w wieku do 3 mies. Grupę porównawczą stanowiło 20 zdrowych niemowląt. U wszystkich badanych oznaczono stężenia kalprotektyny w stolcu, a u chorych na CF oceniono stan odżywienia (standaryzowana masa ciała), zewnątrzwydzielni-czą funkcję trzustki (stężenie elastazy 1 w stolcu) i ekspresję choroby oskrzelowo-płucnej. Wyniki: U znaczącego odsetka chorych na CF w chwili stawiania diagnozy stwierdzono występowanie niedoboru masy ciała. Jednocześnie aż 7 pacjentów (70%) prezentowało kliniczne objawy niewydolności zewnątrzwydzielniczej trzustki. Stęże-nia kalprotektyny wynosiły 1,8-442,0 ng/ml (X śr. ±SEM: 99,0 ±17,0, mediana: 88,8) i były statystycznie istotnie większe niż u zdrowych niemowląt (X śr. ±SEM: 26,6 ±9,0, mediana: 12,5, p < 0,049). Nie stwierdzono występowania istotnej statystycznie korelacji między stężeniami kalprotektyny a wartościami klasycznej (r = 0,027) i konduktometrycznej próby potowej (r = -0,037), standaryzowaną wartością masy ciała (r = -0,096), stężeniem elastazy 1 w stolcu (r = -0,207) oraz ekspresją choroby oskrzelowo-płucnej (r = 0,090). AbstractIntroduction: Cystic fibrosis (CF) is inflammatory and destructive disease with differentiated clinical expression. Conducted studies revealed intestinal inflammation in CF patients. However, available results are limited to children, adolescents and young adults. There are no data assessing the initiation of intestinal inflammation at the youngest age. Therefore, the aim of the present study was been to assess whether intestinal inflammation is present at diagnosis in infants diagnosed in a CF neonatal screening programme. Material and methods: Ten CF infants aged up to 3 months were introduced into the study. Twenty healthy infants served as a control group. Faecal calprotectin concentrations were determined in all studied subjects. In CF infants, nutritional status (standardized body weight), exocrine pancreatic function (faecal elastase-1 concentrations) and the expression of bronchopulmonary disease were also assessed. Results: In a significant percentage of CF patients body weight deficit was present at diagnosis. In 7 patients (70%) clinical symptoms of exocrine pancreatic insufficiency were found. Faecal calprotectin concentrations ranged from 1.8 to 442 ng/ml (mean ±SEM: 99.0 ±17.0, median: 88.8) and were significantly higher than in healthy infants (mean ±SEM: ...

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“…Increased permeability has been associated with the use of nonsteroidal antiinflammatory drugs, 72 celiac disease, 73 inflammatory bowel disease (Crohn's disease), 74 and cystic fibrosis. 75 The mechanism of increased permeability during these illnesses is hypothesized to involve enterocyte death and loss of barrier function at intercellular gaps. As a result, otherwise nonabsorbable substances may enter the body through the gastrointestinal mucosa during critical illness.…”

Section: Gut Permeability In Hospitalized Patients: Absorption Of Nonmentioning

confidence: 99%

“…Enteral nutrition decreases septic complications and decreases gut permeability by enhancement of the immunologic function of the gut. 75 Enteral nutrition may also have beneficial immunologic effects within the mucosa-associated lymphoid tissue. 76 In summary, it is not surprising that FD&C Blue No.…”

Section: Gut Permeability In Hospitalized Patients: Absorption Of Nonmentioning

confidence: 99%

Food Dye Use in Enteral Feedings: A Review and a Call for a Moratorium

Maloney

Ryan

Brasel³

et al. 2002

Nut in Clin Prac

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Pulmonary aspiration of gastric contents is common in enterally fed patients. Tinting enteral feedings with blue dye is thought to aid the early detection of aspiration in hospitalized patients. The blue-dye method is popular despite evidence that it is not sensitive. Reports of absorption of blue dye from enteral feedings in patients with sepsis and other critical illnesses are increasing. The presence of blue and green skin and urine, and serum discoloration has been linked with death. FD&C Blue No.1 and related dyes have toxic effects on mitochondria, suggesting that dye absorption is harmful. This study reviews the literature on the dye method and dye pharmacology, reports the results of a survey of current dye use, and describes 2 recent deaths associated with blue-dye absorption. We concluded that the use of blue dye in enteral feedings should be abandoned and replaced by evidence-based methods for the prevention of aspiration.

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Effects of Therapy With Lansoprazole on Intestinal Permeability and Inflammation in Young Cystic Fibrosis Patients

Cited by 29 publications

References 31 publications

Inflammation of the cystic fibrosis mouse small intestine

Inflammation of the cystic fibrosis mouse small intestine

Early intestinal manifestation in infants with cystic fibrosis – a pilot study

Food Dye Use in Enteral Feedings: A Review and a Call for a Moratorium

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