Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis

Peng, Yu; Zeng, Yuting; Zheng, Tingting; Xie, Xiaoning; Wu, Jianfeng; Fu, Lizhe; Lu, Fuhua; La, Zhang; Chen, Yang; Liu, Xusheng; Wang, Lei

doi:10.1080/13880209.2023.2193595

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…The microbial clique members, B. adolescentis , R. callidus , and P. clara , play various beneficial roles in the human gut microbiome. P. clara is the most recently identified, with comparatively little known about its health benefits; however, a recent study in dialysis patients found that increased abundance of P. clara was associated with reduced constipation − Low abundance of R. callidus has been associated with Parkinson’s disease, colitis and Crohn’s disease, ,, liver disease, and obesity …”

Section: Discussionmentioning

confidence: 99%

“…P. clara is the most recently identified, with comparatively little known about its health benefits; 51 however, a recent study in dialysis patients found that increased abundance of P. clara was associated with reduced constipation. 52 R. callidus is a short-chain fatty-acid-producing bacteria with anti-inflammatory function. 53 − 55 Low abundance of R. callidus has been associated with Parkinson’s disease, 56 colitis and Crohn’s disease, 54 , 57 , 58 liver disease, 55 and obesity.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

Midya,

Lane,

Gennings

et al. 2023

Environ. Sci. Technol.

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Many analytical methods used in gut microbiome research focus on either single bacterial taxa or the whole microbiome, ignoring multibacteria relationships (microbial cliques). We present a novel analytical approach to identify microbial cliques within the gut microbiome of children at 9−11 years associated with prenatal lead (Pb) exposure. Data came from a subset of participants (n = 123) in the Programming Research in Obesity, Growth, Environment and Social Stressors cohort. Pb concentrations were measured in maternal whole blood from the second and third trimesters of pregnancy. Stool samples collected at 9−11 years old underwent metagenomic sequencing to assess the gut microbiome. Using a novel analytical approach, Microbial Co-occurrence Analysis (MiCA), we paired a machine learning algorithm with randomization-based inference to first identify microbial cliques that were predictive of prenatal Pb exposure and then estimate the association between prenatal Pb exposure and microbial clique abundance. With second-trimester Pb exposure, we identified a two-taxa microbial clique that included Bif idobacterium adolescentis and Ruminococcus callidus and a three-taxa clique that also included Prevotella clara. Increasing second-trimester Pb exposure was associated with significantly increased odds of having the two-taxa microbial clique below the median relative abundance (odds ratio (OR) = 1.03, 95% confidence interval (CI) [1.01−1.05]). Using a novel combination of machine learning and causal inference, MiCA identified a significant association between second-trimester Pb exposure and the reduced abundance of a probiotic microbial clique within the gut microbiome in late childhood.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

Midya,

Lane,

Gennings

et al. 2023

Environ. Sci. Technol.

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show abstract

“…and dietary patterns as well as cardiometabolic health, but the conclusions are still controversial [55][56][57][58][59][60]. A study of constipation relief in patients with peritoneal dialysis by using Tiaopi Xiezhuo decoction (TXD) reported that Prevotella was enriched in TXD treatment, suggesting a positive correlation with an improvement in constipation, but its positive correlation with the serum levels of phosphate also suggests a potential health risk [61]. However, in our study, the correlation analysis demonstrated a strong association between Prevotella and defecation volume, fecal water content, intestinal transport rate, 5-HT, and NO, respectively, which indicates that a reduced abundance of Prevotella may be involved in relieving STC in mice treated by L. plantarum GUANKE.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Huang,

Guo,

et al. 2023

Nutrients

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Slow transit constipation (STC) is a prevalent gastrointestinal condition with slow transit, and some probiotics can effectively relieve constipation, but the exact mechanisms have not been fully understood. In this study, we evaluate the impact of Lactiplantibacillus plantarum GUANKE (GUANKE) on diphenoxylate-induced slow transit constipation and speculate on the underlying mechanisms in a mouse model. Administration of L. plantarum GUANKE alleviated constipation indexes, including defecation time, fecal output and water content, and gastrointestinal transit ratio. In addition, GUANKE restored the protein expression of constipation-related intestinal factors (aquaporins (AQPs) and interstitial Cajal cells (ICCs)) in colon tissues measured using immunofluorescence staining; regulated the neurotransmitters and hormones, such as increased levels of 5-hydroxytryptamine, substance P, and motilin; and decreased levels of vasoactive intestinal peptide and nitric oxide in serum, as measured by an ELISA. 16S rRNA and correlation analysis of feces indicated that GUANKE administration effectively reduced constipation-induced Prevotella enrichment and suggested a potential contribution of Prevotella to diphenoxylate-induced STC in mice. GUANKE had no effect on short-chain fatty acids (SCFAs) in cecum content. This study revealed that GUANKE may alleviate constipation in mice through regulating intestinal neurotransmitter and hormone release and altering specific bacterial taxa, rather than by affecting SCFAs and the diversity of microbiota in the gut. Further research is needed to confirm if the findings observed in this study will be consistent in other animal studies or clinical trials.

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“…The microbial clique members, B. adolescentis, R. callidus, and P. clara, play various beneficial roles within the human gut microbiome. P. clara is the most recently identified, with comparatively little known about its health benefits (Morotomi et al 2009); however, a recent study in dialysis patients found that increased abundance of P. clara was associated with reduced constipation (Peng et al 2023). R. callidus is a short-chain-fatty-acid-producing bacteria with anti-inflammatory function (Sánchez-Tapia et al 2020;Satokari et al 2014;Sheng et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Pb exposure is associated with reduced abundance of beneficial gut microbial cliques in late childhood: an investigation using Microbial Co-occurrence Analysis (MiCA)

Midya

Lane

Gennings

et al. 2023

Preprint

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Background: Many analytical methods used in gut microbiome research focus on either single bacterial taxa or the whole microbiome, ignoring multi-bacteria relationships (microbial cliques). We present a novel analytical approach to identify multiple bacterial taxa within the gut microbiome of children at 9-11 years associated with prenatal Pb exposure. Methods: Data came from a subset of participants (n=123) in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort. Pb concentrations were measured in maternal whole blood from the second and third trimesters of pregnancy. Stool samples collected at 9-11 years old underwent metagenomic sequencing to assess the gut microbiome. Using a novel analytical approach, Microbial Co-occurrence Analysis (MiCA), we paired a machine-learning algorithm with randomization-based inference to first identify microbial cliques that were predictive of prenatal Pb exposure and thsen estimate the association between prenatal Pb exposure and microbial clique abundance. Results: With second-trimester Pb exposure, we identified a 2-taxa microbial clique that included Bifidobacterium adolescentis and Ruminococcus callidus, and a 3-taxa clique that added Prevotella clara. Increasing second-trimester Pb exposure was associated with significantly increased odds of having the 2-taxa microbial clique below the 50th percentile relative abundance (OR=1.03,95%CI[1.01-1.05]). In an analysis of Pb concentration at or above vs. below the United States and Mexico guidelines for child Pb exposure, odds of the 2-taxa clique in low abundance were 3.36(95%CI[1.32-8.51]) and 6.11(95%CI[1.87-19.93]), respectively. Trends were similar with the 3-taxa clique but not statistically significant. Discussion: Using a novel combination of machine-learning and causal-inference, MiCA identified a significant association between second-trimester Pb exposure and reduced abundance of a probiotic microbial clique within the gut microbiome in late childhood. Pb exposure levels at the guidelines for child Pb poisoning in the United States, and Mexico are not sufficient to protect against the potential loss of probiotic benefits.

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Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis

Cited by 10 publications

References 45 publications

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Prenatal Pb exposure is associated with reduced abundance of beneficial gut microbial cliques in late childhood: an investigation using Microbial Co-occurrence Analysis (MiCA)

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