Effects of tilisolol on ischemic myocardial metabolism in dogs

Hayase, Nobumasa; Chiba, Kaoru; Abiko, Yasushi; Ichihara, Kazuo

doi:10.1016/0014-2999(94)90336-0

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…However, several investigators suggested that tilisolol has a direct action on smooth muscle cells through ATP-sensitive K+ channels. Protective effects of tilisolol on ischemic heart (7) and a dilatory effect on the coronary arteries were also described (20). Therefore, the possibility that tilisolol has additional effects on the membrane ionic channels of cardiac myocytes under ischemic conditions remains to be tested (1)(2)(3)(4)8,14,23,28).…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular Effects of Tilisolol, a Non‐Selective β‐Adrenergic Blocker

Takagi

Kihara

Mitsuiye

et al. 1998

Cardiovascular Drug Reviews

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Section: Discussionmentioning

confidence: 99%

“…The effects of tilisolol on energy and carbohydrate metabolism in the ischemic myocardium were examined by Hayase et al (7). Five minutes after tilisolol administration (0.2 mgkg iv.…”

Section: Effects On Ischemic Heartsmentioning

confidence: 99%

Cardiovascular Effects of Tilisolol, a Non‐Selective β‐Adrenergic Blocker

Takagi

Kihara

Mitsuiye

et al. 1998

Cardiovascular Drug Reviews

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Role of the sympathetic nervous system in the ischemic and reperfused heart

Hara

Abiko

1996

Myocardial Ischemia: Mechanisms, Reperfusion, Protection

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Takaoka

Nakae

Liu

et al. 1997

Cardiovascular Drugs and Therapy

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The aims of this study were to investigate whether nicorandil (NIC), an ATP-sensitive potassium channel (KATP) opener and nitrate, has antiischemic effects during transient ischemia in pigs, and to investigate whether its effects are due to its KATP-opening action or nitrate action. Myocardial ischemia was induced by ligating the proximal portion of the left anterior descending coronary artery for 1 minute in anesthetized open-chest pigs, and was measured as the magnitude of ST-segment elevation on epicardial electrocardiogram (ECG). Epicardial ST-segment elevation during coronary occlusion was significantly reduced by pretreatment with NIC (3 mg, intracoronary [i.c.]), but not by pretreatment with nitroglycerin (NTG, 0.2 mg, i.c.). Pretreatment with glibenclamide (GLB, a KATP blocker, 6 mg, i.c.) significantly augmented the ST-segment elevation during coronary occlusion. The augmentation of ST-segment elevation by GLB was significantly reduced by subsequent administration of NIC, but not by that of NTG (0.2 mg, i.c.). There were no significant differences between hemodynamic variables immediately before coronary occlusion with and without pretreatment. The intracoronary administration of NIC (3 mg) significantly shortened the endocardial monophasic action potential durations at 50% (MAPD50) and 90% repolarization (MAPD90) by 28.3 +/- 6.9% and 17.0 +/- 4.7%, respectively. These results suggest that the intracoronary administration of NIC has antiischemic effects during transient ischemia via KATP activation in myocardium.

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Effects of tilisolol on ischemic myocardial metabolism in dogs

Cited by 5 publications

References 21 publications

Cardiovascular Effects of Tilisolol, a Non‐Selective β‐Adrenergic Blocker

Cardiovascular Effects of Tilisolol, a Non‐Selective β‐Adrenergic Blocker

Role of the sympathetic nervous system in the ischemic and reperfused heart

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