Effects of tipepidine on MK-801-induced cognitive impairment in mice

Miki, Risa; Honda, Ikutaro; Hamasaki, Ryota; Kawahara, Ryo; Soeda, Fumio; Shirasaki, Tetsuya; Misumi, Shogo; Takahama, Kazuo

doi:10.1016/j.brainres.2018.12.032

Cited by 5 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for the Y-maze test, several articles point out that MK-801 is effective in inducing working memory deficits in mice, as observed by the reduction of the spontaneous alternations percentage. Additionally, the ability of MK-801 to promote hyperlocomotion is also reported in the literature, as it is able to increase the number of entries in the Y-maze arms (Maurice et al, 1997;Miki et al, 2019;Hasegawa et al, 2016).…”

Section: Discussionmentioning

confidence: 75%

“…However, most articles with an experimental design similar to ours appear to consider the ability of a drug to prevent substance-induced deficits only if there is a statistical significance in comparison to the positive control (Akefe et al, 2022;Bruin et al, 2010;Cheng et al, 2011;Eduviere et al, 2015;Maurice et al, 1997;Miki et al, 2019;Roberts et al, 2010). In order to adopt the interpretation of greater statistical rigor, and although the groups previously treated with ortho-eugenol have increased the rate of spontaneous alternations, it was not possible to state its effectiveness in the prevention of working memory deficits induced by MK-801, since there was no statistically significant difference when compared to the positive control.…”

Section: Discussionmentioning

confidence: 99%

“…In the experimental groups, ortho-eugenol and MK-801 were administered intraperitoneally 45 and 30 minutes before the tests, respectively. In the positive control group, only the administration of MK-801 was performed 30 minutes before the behavioral tests, as described in several studies (Bruin et al, 2010;Maurice et al, 1994;Miki et al, 2019;Rychtyk et al, 2019). The negative control group received only saline 30 minutes before the tests.…”

Section: Y-maze Testmentioning

confidence: 99%

See 2 more Smart Citations

Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice

Godoy,

Macedo,

Gervazio

et al. 2023

Braz. J. Biol.

View full text Add to dashboard Cite

Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies. Additionally, its effects appear to be dependent on the noradrenergic and dopaminergic systems. Depression and anxiety disorders are known to share a great overlap in their pathophysiology, and many drugs are effective in the treatment of both diseases. Furthermore, high levels of anxiety are related to working memory deficits and increased oxidative stress. Thus, in this study we investigated the effects of acute treatment of ortho-eugenol, at 50, 75 and 100 mg/kg, on anxiety, working memory and oxidative stress in male Swiss mice. Our results show that the 100 mg/kg dose increased the number of head-dips and reduced the latency in the hole-board test. The 50 mg/kg dose reduced malondialdehyde levels in the prefrontal cortex and the number of Y-maze entries compared to the MK-801-induced hyperlocomotion group. All doses reduced nitrite levels in the hippocampus. It was also possible to assess a statistical correlation between the reduction of oxidative stress and hyperlocomotion after the administration of ortho-eugenol. However, acute treatment was not able to prevent working memory deficits. Therefore, the present study shows that ortho-eugenol has an anxiolytic and antioxidant effect, and was able to prevent substance-induced hyperlocomotion. Our results contribute to the elucidation of the pharmacological profile of ortho-eugenol, as well as to direct further studies that seek to investigate its possible clinical applications.

show abstract

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Y-maze Testmentioning

confidence: 99%

See 1 more Smart Citation

Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice

Godoy,

Macedo,

Gervazio

et al. 2023

Braz. J. Biol.

View full text Add to dashboard Cite

show abstract

“…A tipepidine overdose is presumed to affect the central nervous system by inhibiting GIRK channels, resulting in excessive excitement and impaired consciousness. Tipepidine is being investigated as a treatment option for depression, Alzheimer's disease, and attention‐deficit / hyperactivity disorders 4,5 …”

Section: Figmentioning

confidence: 99%