Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats

Lee, Shu-Ping; Mar, Guang-Yuan; Ng, Lean‐Teik

doi:10.1007/s00421-009-1159-6

Cited by 64 publications

(54 citation statements)

References 54 publications

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“…SOD plays an early role in the defense against free radicals by converting the superoxide radical to peroxides. GPx-1 reduces lipid hydroperoxide and hydrogen peroxide while catalase is effective only against hydrogen peroxide [36]. The decreased activity of SOD in the mice exposed to waterpipe smoke might reduce the dismutation of free radicals into hydrogen peroxides, resulting in lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

Charab

Abouzeinab

Moustafa

2016

Biol Trace Elem Res

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Waterpipe smoking is common in the Middle East populations and results in health problems. In this study, we investigated the effects of exposure of mice to waterpipe smoke on oxidative stress in lungs and liver and the effects of selenium administration before smoke exposure on the oxidative stress. Twenty-four mice were divided equally into four groups: (i) the control mice received no exposure or treatment; (ii) mice exposed to waterpipe smoke; (iii) mice received intraperitoneal injection of 0.59 μg selenium/kg body weight as sodium selenite 15 min before the exposure to waterpipe smoke; and (iv) mice received intraperitoneal injection of 1.78 μg selenium/kg body weight as sodium selenite 15 min before the exposure to waterpipe smoke. Mice were exposed to waterpipe smoke every other day for four times within 8 successive days. Malondialdehyde and nitric oxide levels were significantly higher in the lungs and liver, while the activities of superoxide dismutase, glutathione peroxidase-1, and catalase were significantly lower in the waterpipe smoke group when compared to control mice. Treating mice with 1.78 μg selenium/kg body weight significantly restored the normal levels of these parameters. Histological examinations of lungs and liver confirmed the protective actions of selenium against the effects of exposure to waterpipe smoke. In conclusion, exposure of mice to waterpipe smoke-induced oxidative stress in lungs and liver. Administration of low level of selenium, 1.78 μg selenium/kg body weight as sodium selenite, exerted protective effects against oxidative stress induced by exposure to waterpipe smoke.

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Section: Discussionmentioning

confidence: 99%

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

Charab

Abouzeinab

Moustafa

2016

Biol Trace Elem Res

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“…In particular, physical fatigue induced by strenuous exercise is thought to lead to a deterioration in performance, causing a decrease in muscular power and endurance, as well as in mental functions (20,21). The underlying mechanism suggests that strenuous exercise accumulates metabolic products (e.g., reactive oxygen species (ROS), lipid peroxides and lactic acid), and leads to oxidative stress, which can potentially contribute to fatigue (22,23).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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Abstract. In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise. The presented results indicated that pre-treatment of NS extract significantly increased the time to exhaustion. In hemodynamic parameters, NS extract increased blood pO 2 and O 2sat , but decreased pCO 2 . For underlying mechanisms, NS extract protected depletion of energy, indicated by increased levels of blood pH, glucose and tissue glycogen contents, and decreased levels of blood lactate, tissue lactic dehydrogenase and creatine kinase, when the NS extract was pre-treated. In addition, the NS extract inhibited oxidative stress following exhaustive swimming, as reflected by the results of increased levels of superoxide dismutase and redox ratio, and decreased the level of malondialdehyde when the NS extract was pre-treated. Collectively, the present study demonstrated that NS extract has an anti-fatigue activity against exhaustive swimming by energy restoration and oxidative-stress defense.

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“…Numerous studies have demonstrated that antioxidant enzymes play an important function in preventing exercise-induced oxidative stress, and reduced activities or expressions of antioxidant enzymes may cause free radical damage in tissues [29]. As the first line of defense in the body against oxidative stress, SOD can completely inactivate superoxide anion radicals [30].…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides from Polygonatum odoratum strengthen antioxidant defense system and attenuate lipid peroxidation against exhaustive exercise-induced oxidative stress in mice

Yang¹,

Zhang²

2017

Trop. J. Pharm Res

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Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats

Cited by 64 publications

References 54 publications

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

The Protective Effect of Selenium on Oxidative Stress Induced by Waterpipe (Narghile) Smoke in Lungs and Liver of Mice

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Polysaccharides from Polygonatum odoratum strengthen antioxidant defense system and attenuate lipid peroxidation against exhaustive exercise-induced oxidative stress in mice

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