Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: A pilot study

Lee, Young Bok; Eun, Young Sun; Lee, Ji Hae; Cheon, Min Seok; Park, Yong Gyu; Cho, Baik Kee; Park, Hyun Jeong

doi:10.1111/j.1346-8138.2012.01680.x

Cited by 44 publications

(43 citation statements)

References 3 publications

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“…The increase in hair shaft density and hair count was significant in growth factor plus microneedling group. Also patients' satisfaction was reported to be higher in the same group compared to saline group [42].…”

Section: Evidence For Efficacymentioning

confidence: 85%

“…Additionally, transient micropores formed through the procedure allow the delivery of molecules into the epidermis. Therefore, after microneedling many cosmeceutical agents have been suggested to be delivered deep to the skin [37,42,43]. Accordingly, in mesotherapy, substances can be given with mesoroller device, as mentioned above [11].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…No serious side effects have been associated with microneedling [37,43]. Patients can complaint from mild pain [42]. As the microchannels close immediately after the application, infection is not expected after the procedure [36].…”

Section: Side Effectsmentioning

confidence: 99%

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Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet-rich plasma, low-level light therapy, and stem-cell therapy with variable outcomes are reviewed in this chapter.

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Section: Evidence For Efficacymentioning

confidence: 85%

Section: Mechanism Of Actionmentioning

confidence: 99%

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Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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“…One half of the scalp was treated with five weekly sessions with a proprietary topical growth factor application followed by 0.5‐mm microneedling treatment to increase drug penetration. The other half of the scalp served as the control and received a treatment with saline solution followed by microneedling . The topical growth factor solution was made of fibroblast growth factor, vascular endothelial growth factor, insulin‐like growth factor, keratinocyte growth factor, stem cell factor, superoxide dismutase and Noggin .…”

Section: Microneedling and Androgenetic Alopeciamentioning

confidence: 99%

Microneedling for the treatment of hair loss?

Fertig

Gamret

Cervantes

et al. 2017

Acad Dermatol Venereol

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Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia (AGA) and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet-rich plasma and topical steroids, and shown to stimulate hair follicle growth. It is thought that microneedling facilitates penetration of such first-line medications, and this is one mechanism by which it promotes hair growth. To date, the area most studied and with the most success has been microneedling treatment of AGA. While the current evidence does not allow one to conclude superiority of microneedling over existing standard therapies for hair loss, microneedling shows some promise in improving hair growth, especially in combination with existing techniques. This review summarizes the current literature regarding microneedling in the treatment of alopecia and calls for further studies to define a standard treatment protocol.

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“…Although some clinical trials were done using the drug delivery effect of microneedle on patients with alopecia, no previous study showed the therapeutic effect of microneedle itself on hair growth by wounding 1 10 11 . We hypothesized that microwounds formed by repeated microneedle stimulation could induce hair growth.…”

Section: Introductionmentioning

confidence: 99%

Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

et al. 2016

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BackgroundMicroneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding.ObjectiveThe aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model.MethodsA disk microneedle roller was applied to each group of mice five times a week for three weeks. First, to identify the optimal length and cycle, microneedles of lengths of 0.15 mm, 0.25 mm, 0.5 mm, and 1 mm and cycles of 3, 6, 10, and 13 cycles were applied. Second, the effect of hair growth and hair-growth-related genes such as Wnt3a, β-catenin, vascular endothelial growth factor (VEGF), and Wnt10b was observed using optimized microneedle. Outcomes were observed using visual inspection, real-time polymerase chain reaction, and immunohistochemistry.ResultsWe found that the optimal length and cycle of microneedle treatment on hair growth was 0.25 mm/10 cycles and 0.5 mm/10 cycles. Repeated microneedle stimulation promoted hair growth, and it also induced the enhanced expression of Wnt3a, β-catenin, VEGF, and Wnt10b.ConclusionOur study provides evidence that microneedle stimulation can induce hair growth via activation of the Wnt/β-catenin pathway and VEGF. Combined with the drug delivery effect, we believe that microneedle stimulation could lead to new approaches for alopecia.

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Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: A pilot study

Cited by 44 publications

References 3 publications

Cosmetic Procedures in the Treatment of Alopecia

Cosmetic Procedures in the Treatment of Alopecia

Microneedling for the treatment of hair loss?

Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

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