Effects of Topical N-Acetylcysteine on Skin Hydration/Transepidermal Water Loss in Healthy Volunteers and Atopic Dermatitis Patients

Nakai, Kozo; Yoneda, Kozo; Murakami, Yumi; Koura, Ayako; Maeda, Reiko; Tamai, Asuka; Ishikawa, Emiko; Yokoi, Isao; Moriue, Junko; Moriue, Tetsuya; Kubota, Yasuo

doi:10.5021/ad.2015.27.4.450

Cited by 18 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since NAC, an antioxidant, strongly suppresses the Th2-mediated IL-4 response and mildly suppresses the secretion of IL-5 and INF-γ, it is useful for the treatment of Th2-related diseases, such as atopic dermatitis [ 62 ]. Previous studies demonstrated that NAC improved the epidermal barrier function of patients with atopic dermatitis [ 63 , 64 ].…”

Section: Ros and Skin Diseasesmentioning

confidence: 99%

What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

Nakai

Tsuruta

2021

IJMS

Self Cite

172

View full text Add to dashboard Cite

Oxygen in the atmosphere is a crucial component for life-sustaining aerobic respiration in humans. Approximately 95% of oxygen is consumed as energy and ultimately becomes water; however, the remaining 5% produces metabolites called activated oxygen or reactive oxygen species (ROS), which are extremely reactive. Skin, the largest organ in the human body, is exposed to air pollutants, including diesel exhaust fumes, ultraviolet rays, food, xenobiotics, drugs, and cosmetics, which promote the production of ROS. ROS exacerbate skin aging and inflammation, but also function as regulators of homeostasis in the human body, including epidermal keratinocyte proliferation. Although ROS have been implicated in various skin diseases, the underlying mechanisms have not yet been elucidated. Current knowledge on ROS-related and oxidative stress-related skin diseases from basic research to clinical treatment strategies are discussed herein. This information may be applied to the future treatment of skin diseases through the individual targeting of the ROS generated in each case via their inhibition, capture, or regulation.

show abstract

Section: Ros and Skin Diseasesmentioning

confidence: 99%

What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

Nakai

Tsuruta

2021

IJMS

Self Cite

172

View full text Add to dashboard Cite

show abstract

“…As systemic and topical forms, NAC is used in dermatologic applications. [ 26 27 28 35 36 37 38 39 40 41 ] Systematic reviews and meta-analyses in RCTs confirmed the safety, tolerability profile, and effectiveness of NAC in wound healing, photoprotection, pseudoporphyria, xeroderma pigmentosum, onychophagia, systemic sclerosis, Type-I lamellar ichthyosis, toxic epidermal necrolysis, eczema, trichotillomania, acne vulgaris, and bullous morphea. [ 43 ]…”

Section: Resultsmentioning

confidence: 95%

N-acetylcysteine and coronavirus disease 2019: May it work as a beneficial preventive and adjuvant therapy? A comprehensive review study

et al. 2020

View full text Add to dashboard Cite

Background: Coronaviruses are major pathogens of respiratory system causing different disorders, including the common cold, Middle East respiratory syndrome, and severe acute respiratory syndrome. Today's global pandemic coronavirus disease 2019 (COVID-19) has high mortality rate, with an approximate of 20% in some studies, and is 30–60 times more fatal than the common annual influenza, However, there is still no gold standard treatment for it. N-acetylcysteine (NAC) is a well-known multi-potential drug with hypothetically probable acceptable effect on COVID-related consequences, which we completely focused in this comprehensive review. Materials and Methods: PubMed, Scopus, Science Direct, and Google Scholar have been searched. Study eligibility criteria: efficacy of NAC in various subclasses of pathogenic events which may occur during COVID-19 infection. Efficacy of NAC for managing inflammatory or any symptoms similar to symptoms of COVID-19 was reviewed and symptom improvements were assessed. Results: Randomized clinical trials introduced NAC as an antioxidant glutathione analog and detoxifying agent promoted for different medical conditions and pulmonary disorders to alleviate influenza and reduce mortality by 50% in influenza-infected animals. The beneficial effects of NAC on viral disorders, including Epstein–Barr virus, HIV and hepatitis, and well-known vital organ damages were also exist and reported. Conclusion: We classified the probable effects of NAC as oxidative-regulatory and apoptotic-regulatory roles, antiviral activities, anti-inflammatory roles, preventive and therapeutic roles in lung disorders and better oxygenation functions, supportive roles in intensive care unit admitted patients and in sepsis, positive role in other comorbidities and nonpulmonary end-organ damages or failures and even in primary COVID-associated cutaneous manifestations. Based on different beneficial effects of NAC, it could be administered as a potential adjuvant therapy for COVID-19 considering patient status, contraindications, and possible drug-related adverse events.

show abstract

“…[ 22 ] reported a dose-dependent manner with NAC concentrations of 0.1 mM to 1.0 mM by mice burn model. Furthermore, some previous studies have pointed out the specific recommended doses for NAC in dermatologic conditions [ 41 , 42 ]. In this present research, compared with the NAC loading concentration of 100 mg/L, the GCN500 mg/L treated wound presented a more uniform and thicker collagen bundle deposition, better epidermal maturation with uniform thickness and more angiogenesis ( Figs.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

Qian

Guo

et al. 2021

Regenerative Biomaterials

View full text Add to dashboard Cite

Associated with persistent oxidative stress, altered inflammatory responses, poor angiogenesis and epithelization, wound healing in diabetic patients is impaired. N-acetylcysteine (NAC) is reported to resist excess reactive oxygen species (ROS) production, prompt angiogenesis and maturation of the epidermis. Studies have revealed that graphene oxide (GO) can regulate cellular behavior and form cross-links with naturally biodegradable polymers such as collagen (COL) to construct composite scaffolds. Here, we reported a COL-based implantable scaffold containing a mixture of GO capable of the sustained delivery of NAC to evaluate the wound healing in diabetic rats. The morphological, physical characteristics, biocompatibility and NAC release profile of the GO-COL-NAC (GCN) scaffold were evaluated in vitro. Wound healing studies were performed on a 20 mm dorsal full-skin defect of streptozotocin (STZ)-induced diabetic rats. The injured skin tissue was removed at the 18th day post-surgery for histological analysis and determination of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) activity. In diabetic rats, we confirmed that the GCN scaffold presented a beneficial effect in enhancing the wound healing process. Additionally, due to the sustained release of NAC, the scaffold may potentially induce the antioxidant defense system, upregulating the expression levels of the antioxidant enzymes in the wound tissue. The findings revealed that the antioxidant biocompatible composite collagen dressing could not only deliver NAC in situ for ROS inhibition but also promote the wound healing process. This scaffold with valuable therapy potential might enrich the approaches for surgeon in diabetic wound treatment in the future.

show abstract

Effects of Topical N-Acetylcysteine on Skin Hydration/Transepidermal Water Loss in Healthy Volunteers and Atopic Dermatitis Patients

Cited by 18 publications

References 6 publications

What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

N-acetylcysteine and coronavirus disease 2019: May it work as a beneficial preventive and adjuvant therapy? A comprehensive review study

Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

Contact Info

Product

Resources

About