Effects of topical oxygen therapy on ischemic wound healing

Rao, C. Radha Kishan; Xiao, Ling; Liu, Hongwei; Li, Shenghong; Lu, Jin-Qiang; Li, Jiang-Xuan; Gu, Song

doi:10.1589/jpts.28.118

Cited by 15 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Pre-clinical studies have demonstrated its effect at short (vasoconstriction, edema reduction, phagocyte activation) and long (angio, osteo, and collagenogenesis) term therapy. [33][34][35][36] When applied topically, oxygen reaches wounds more readily, 37 reducing the risk of post-operative skin infections 38 and local tissue ischemia. 39 However, most evidence for wound treatment has been reported aside from the anterior neck area, 21 , 40 , 41 and the effect of topical oxygen therapy post-thyroid/parathyroid surgery has not been widely assessed.…”

Section: Discussionmentioning

confidence: 99%

Continuous Diffusion of Oxygen Adjunct Therapy to Improve Scar Reduction After Cervicotomy – A Proof of Concept Randomized Controlled Trial

Zulbaran-Rojas

Mishra

Pham

et al. 2021

Journal of Surgical Research

View full text Add to dashboard Cite

Background: Dressing materials are known to influence post-operative surgical wound healing and scar formation (SF). A particular dressing that could promote wound hydration is essential to ensure quick epithelialization and reduce SF. This study examined the effectiveness of a novel Continuous Diffusion of Oxygen (CDO) dressing to reduce scar length post cervicotomy.Methods: A randomized controlled trial was performed in patients undergoing cervicotomy, either for thyroid or parathyroid disease. Patients were randomized to either control (CG) or intervention (IG) groups. The IG received a portable CDO system (TransCu O2, EO2 Concepts Inc., TX, USA), whereas the CG received a standard dressing for a 4-week period. The primary outcome was > 10% of scar length reduction and %change in scar length.Results: 21 patients were recruited (Age: 53 ± 16 years; 90% female; CG = 9, IG = 12). 5 patients were lost to follow-up. At 4 weeks, 88.8% of the IG significantly achieved > 10% of scar reduction (versus CG = 28.5%, d = 0.48, P = 0.049), showing a 40.4% smaller scar (15.7% versus 11.2%, d = 0.13, P = 0.72) compared to the CG. However, the difference was not significant. A sub-sample of patients undergoing thyroidectomy showed a significant scar reduction using CDO (IG = 11.6% versus CG = 5.1%, d = 2.96, P = 0.009).Conclusions: This is the first study to assess scar reduction using CDO adjunct therapy after cervicotomy. Advanced CDO dressings may assist wound healing showing improved out-

show abstract

Section: Discussionmentioning

confidence: 99%

Continuous Diffusion of Oxygen Adjunct Therapy to Improve Scar Reduction After Cervicotomy – A Proof of Concept Randomized Controlled Trial

Zulbaran-Rojas

Mishra

Pham

et al. 2021

Journal of Surgical Research

View full text Add to dashboard Cite

show abstract

“…Both studies found an increase in wound oxygenation and reported pO 2 measurements of 40 mmHg in the TPOT‐treated wounds, which was more than 4 times that which was measured in the control groups . Rao et al exposed rats with ischaemic limb wounds to TPOT, showing increased collagen fibre accumulation, better neovascularisation and a significant decrease in healing time in the wounds treated with TPOT compared to the controls …”

Section: B Topical Pressurised Oxygen Therapymentioning

confidence: 99%

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

Sayadi

Banyard

Ziegler

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent.

show abstract

“…Oxygen's indispensable role in tissue repair has precipitated investigation of oxygen as a wound care intervention. Hyperbaric oxygen therapy is widely known, but the past two decades have seen the rise of an innovative form of oxygen therapy involving the topical application of oxygen to the open wound [13]. Based on transcutaneous oxygen partial pressure measurements (TcPO 2 ), hypoxic wounds (TcPO 2 0 -30 mm Hg) are identified by the presence of yellow necrotic slough (TcPO 2 13 -30 mm Hg) or black gangrene (TcPO 2 0 -13 mm Hg).…”

Section: Hyperbaric Oxygen Delivered As Topical Hyperbaric Oxygen Thementioning

confidence: 99%

A Disruptive Treatment to Prevent Amputation and Enhance Limb Salvage in an Elderly Patient

Benitez¹,

Duran²,

Matos-Ruiz³

et al. 2019

JCDSA

View full text Add to dashboard Cite

Background: Chronic wounds are a growing problem internationally, termed a silent epidemic. To combat this epidemic, it is not sufficient to rely on traditional wound care treatments alone, but to look to innovative and alternative therapies. The indispensable role of oxygen in wound healing is well-discussed in the literature, and in the past two decades the topical application of oxygen has shown promising results in the healing of chronic wounds. However, the toxic effects of oxygen are usually not appreciated and can often lead to wound necrosis and gangrene in wounds with compromised blood supply. While wounds with adequate blood supply contain free radical quenchers (catalase, superoxide dismutase and reduced glutathione) which neutralize the free radicals (reactive oxygen species) released as a by-product of the Krebs cycle, wounds with deficient blood supply are deficient in free radical quenchers and are further damaged by exposure to oxygen as a result of reperfusion injury/oxygen toxicity. Topical hyperbaric oxygen (THOT®) uses low oxygen tensions in the hyperbaric range to stimulate angiogenesis, while preventing excessive oxygen toxicity. The result is the induction of marked angiogenesis, with increasing capacity for quenching reactive oxygen species, resulting in wound healing of ischemic wounds. Case Presentation: This case report describes a 95-year-old Caucasian female who presented with a stage IV chronic necrotic ulcer on her lower left leg. Surgical pathology results revealed calcifying vasculopathy, which is thought to be responsible for deficient blood supply to the leg, leading to a necrotic, chronic leg ulcer of her left leg. After traditional wound therapies were unsuccessful, she was considered for leg amputation. The introduction of adjunctive treatment with topical hyperbaric oxygen therapy saw complete healing of the wound within 15 weeks. The wound remained closed, without the presence of scar tissue, with no signs of wound breakdown at three-month and six-month follow-ups. Conclusions: Chronic hypoxic wounds with vascular insufficiency are con-How to cite this paper:

show abstract

Effects of topical oxygen therapy on ischemic wound healing

Cited by 15 publications

References 22 publications

Continuous Diffusion of Oxygen Adjunct Therapy to Improve Scar Reduction After Cervicotomy – A Proof of Concept Randomized Controlled Trial

Continuous Diffusion of Oxygen Adjunct Therapy to Improve Scar Reduction After Cervicotomy – A Proof of Concept Randomized Controlled Trial

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

A Disruptive Treatment to Prevent Amputation and Enhance Limb Salvage in an Elderly Patient

Contact Info

Product

Resources

About