Effects of topical preparations on the erythemogenicity of UVB: Implications for psoriasis phototherapy

Lebwohl, Mark; Martinez, Joe; Weber, Paul J.; DeLuca, Robert

doi:10.1016/0190-9622(95)90071-3

Cited by 62 publications

(61 citation statements)

References 4 publications

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“…In the case of sunscreen testing, the type of products may influence the results [8,13], but in the case of emollients, given the low interaction factors, the na ture of the formulation has heen shown to have at most lit tle effect on the accuracy of the measurement |6j. The emollients were tested at an application density of 2 mg cm 2, corresponding to the value recommended for the determination of sun protection factors in vivo 114], Higher application densities may be encountered in the clinic [5,7,15). The maximum that might be used clini cally is considered to be 4 mg-cm 2 |6).…”

Section: Discussionmentioning

confidence: 99%

Emollients and Photo(chemo)therapy: A Call for Caution

Gabard¹,

Treffel²,

Bieli³

et al. 1996

Dermatology

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Background: Emollients used for skin care, treatment of a disease or lubrication, before irradiation during the course of phototherapy or photochemotherapy, may significantly interfere with the transmission of UV light and may influence the outcome of the therapy. Objective: These experiments should characterize and quantify the possible interactions of usual emollients with UV light transmission. Method: The method was an in vitro technique similar to the one already used for the determination of sun protection factors of topical sunscreen preparations. Results: Among the products tested, two showed a significant photoprotection capable of interfering with the course of therapy. Oils enhanced UV light transmission significantly. Conclusion: Emollients may show significant interference with UV light transmission during phototherapy or photochemotherapy. The outcome and course of the therapy could thus be significantly modified.

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Section: Discussionmentioning

confidence: 99%

Emollients and Photo(chemo)therapy: A Call for Caution

Gabard¹,

Treffel²,

Bieli³

et al. 1996

Dermatology

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“…Adjunctive therapy was limited to emollients known not to significantly impede UV transmission 23,24 and standard topical treatments for scalp, face, and flexures. End points for stopping therapy were, as in our routine practice, clearance (no palpable psoriasis remaining) or "minimal residual activity," defined as trace disease, below knees or on sacrum only.…”

Section: Treatment Regimenmentioning

confidence: 99%

UV-B Phototherapy Clears Psoriasis Through Local Effects

Dawe

Cameron²,

Yule³

et al. 2002

Arch Dermatol

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Objective: To determine if UV-B phototherapy clears psoriasis through systemic effects.Design: Randomized, within-subject comparison of change in psoriasis in 3 plaques in patients attending for whole-body UV-B therapy. Change in patients' psoriasis plaques covered during UV-B treatment was compared with plaques in an untreated control group.Setting: University hospital phototherapy unit. Patients:The study population comprised 17 patients with chronic plaque psoriasis treated with UV-B and 24 psoriasis control patients awaiting UV-B phototherapy.Interventions: Treatment with a standard 3-times weekly narrowband TL-01 UV-B regimen. Three similar plaques were randomly allocated to be covered every treatment, covered for 2 of 3 weekly treatments, and exposed to local UV-B every treatment. Similar plaques were selected in control patients (awaiting but not yet started UV-B therapy). Severity of psoriasis plaques was assessed using a scaling, erythema, and induration (SEI) scoring system.Main Outcome Measures: Change in SEI score of the selected plaques over the complete treatment course for UV-B-treated patients and change over 3 weeks in SEI score of plaques covered during UV-B treatment compared with that of plaques in controls.Results: There was a significant (PϽ.001) difference in how much the SEI score changed in the 3 plaques in UV-B-treated patients. It fell by a mean of 7.6 for uncovered plaques compared with 3.2 for plaques covered during each UV-B exposure (95% confidence interval for difference, 3.0 to 5.8). In patients awaiting UV-B, SEI score of plaques fell by a mean of 0.4 over 3 weeks, compared with a mean fall of 1.4 for covered plaques in UV-B-treated patients (95% confidence interval for difference in means, 0.1 to 2.0). Conclusions:If UV-B therapy has any systemic effect capable of improving psoriasis, this effect is small and unlikely to be of clinical importance. It is insufficient to alter interpretation of findings of within-subject comparative phototherapy studies. UV-B phototherapy works for chronic plaque psoriasis through local effects.

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“…Fototerapi ünitelerinde bu amaçla en s›k kullan›lan nemlendirici vazelindir 7,8 . Son zamanlarda baz› nemlendiricilerin ultraviyolenin deriye absorbsiyonunu engelleyerek tedaviyi olumsuz etkileyebildikleri görülmüfltür 4,9,10 . Bu çal›flmada fototerapi ünitelerinde s›k kullan›lan üç nemlendiricinin fototerapi/fotokemoterapi üzerine olumlu ya da olumsuz etkilerinin minimal eritem dozu (MED) ve minimal fototoksik doz (MFD) de¤erleri kullan›larak de¤erlendirilmesi amaçlanm›flt›r.…”

Section: Giriflunclassified

“…Fototerapi ve fotokemoterapi s›ras›nda s›k kullan›lan bu ajanlar›n tedavinin etkinli¤i üzerinde olumlu ya da olumsuz etkilerinin olup olmad›¤› konusu ise tart›flmal›d›r. UV tedavisi öncesi sürülen nemlendiricilerin derinin UV geçirgenli¤ini artt›rarak tedaviye olumlu etkilerinin olabilece¤ini düflünenlerin yan›s›ra, baz› nemlendiricilerin günefl koruyucu gibi etki göstererek UV geçirgenli¤ini azaltaca¤›n› düflünen yazarlar da vard›r 4,9,[11][12][13] . Bu çal›flmada, normal deriye fototerapi ve fotokemoterapi öncesi sürülen 3 farkl› nemlendiricinin MED ve MFD de¤erlerini nas›l etkiledi¤ini görmek amaçland›.…”

Section: Tart›flmaunclassified

Effects of Different Emollients on Minimal Erythema Dose and Minimal Phototoxic Dose

Demirsoy¹,

Bayramgürler²,

Aktürk³

et al. 2011

TURKDERM

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ÖzetAmaç: Nemlendiriciler fototerapi ve fotokemoterapi s›ras›nda adjuvan tedavi olarak s›k kullan›lan ajanlard›r. Bu nedenle kullan›lan nemlendiricinin ultraviyole (UV) ›fl›¤›yla iliflkisinin ne yönde olaca¤›n›n bilinmesi önemlidir. Bu deneysel çal›flmada s›v› / kat› vazelin kar›fl›m›, Nutraplus ® losyon, Basiscreme ® 'in minimal eritem dozu (MED) ve minimal fototoksik doz (MFD) üzerine etkilerinin incelenmesi amaçland›. Gereç ve Yöntem: K›rk sa¤l›kl› gönüllünün ön kol iç yüzleri 4 deney sahas›na ayr›ld›. Oluflturulan 4 deney sahas›ndan 3'üne yukar›da ad› geçen nemlendiriciler uygulan›p, bir deney sahas› kontrol grubu olarak bofl b›rak›ld›. Gönüllülerin 20'sine dar bant UVB uygulanarak MED, 20'sine PUVA uygulanarak MFD de¤erleri hesapland›. Bulgular: Çal›flmam›zda s›v›/ kat› vazelin kar›fl›m› ile elde edilen MED de¤erleri ortalamas› kontrol grubu MED de¤erleri ortalamas›na göre anlaml› derecede yüksek bulundu. Nutraplus ® losyon ve Basiscreme ® ortalama MED de¤erlerini de¤ifltirmedi. Fotokemoterapi uygulanan gönüllülerde, deri tipi üç olanlarda Basiscreme® ile elde edilen ortalama MFD de¤eri, kontrol grubuna göre daha düflük bulundu. S›v›/ kat› vazelin ve Nutraplus ® losyon uygulamas›n›n ard›ndan elde edilen ortalama MFD de¤erlerinde, kontrol grubuyla karfl›laflt›r›ld›¤›nda anlaml› bir de¤ifliklik olmad›¤› görüldü. Sonuç: Fototerapi ve fotokemoterapi öncesinde kullan›lan nemlendiriciler UV ›fl›nlar›n›n iletimini de¤ifltirebilmektedir. Bu de¤iflim, tedavinin sonucu ve uzun dönemdeki yan etkileri üzerinde önemli bir etkiye sahip olabilir. Çal›flmam›z›n sonuçlar›na göre, fototerapi öncesi s›v› / kat› vazelin kar›fl›m› kullan›lmas›n›n tedaviyi olumsuz etkileyebilece¤ini düflünüyoruz. (Türkderm 2011; 45: 33-6) Anahtar Kelimeler: Fotokemoterapi, fototerapi, nemlendirici, yumuflat›c› SummaryBackground and Design: Emollients are commonly used agents as adjunctive therapy during phototherapy and photochemotherapy. It is therefore, important to know if the emollients used interact in any way with ultraviolet (UV) light. In this experimental study, we aimed to investigate the possible effects of liquid/pure vaseline mixture, Nutraplus ® lotion and Basiscreme ® on minimal erythema dose (MED) and minimal phototoxic dose (MPD). Material and Method:The inner parts of the forearm of 40 healthy volunteers were divided into 4 experimental test fields. The above emollients were applied to the 3 experimental test fields and no emollient was applied to one field, which was used as control group. MED was determined in 20 of the volunteers receiving narrow band UVB, MPD was determined in 20 of the volunteers receiving PUVA. Results: According to our study results, the mean MED score obtained after application of liquid/pure vaseline mixture was significantly higher than that in the control group. Nutraplus ® lotion and Basiscreme ® did not change the mean MED scores. In volunteers receiving photochemotherapy, the mean MPD score obtained after Basiscreme ® application was significantly lower in those having skin phototype III when co...

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Effects of topical preparations on the erythemogenicity of UVB: Implications for psoriasis phototherapy

Cited by 62 publications

References 4 publications

Emollients and Photo(chemo)therapy: A Call for Caution

Emollients and Photo(chemo)therapy: A Call for Caution

UV-B Phototherapy Clears Psoriasis Through Local Effects

Effects of Different Emollients on Minimal Erythema Dose and Minimal Phototoxic Dose

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