Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial

Shamloo, Marzieh Beigom Bigdeli; Nasiri, Morteza; Maneiy, Mohammad; Dorchin, Mohammad; Mojab, Faraz; Bahrami, Hadi; Naseri, Marzieh Sadeghzadeh; Kiarsi, Maryam

doi:10.1016/j.ctcp.2019.01.016

Cited by 21 publications

(35 citation statements)

References 21 publications

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“…Interventions for preventing intravenous therapy‐related phlebitis used in 7 studies were a glyceryl trinitrate patch (Çökmez et al, 2003), sesame oil (Bagheri‐Nesami et al, 2015; Nekuzad et al, 2012), rosemary ointment (Sheikhi et al, 2018), chamomile ointment (Sharifi‐Ardani et al, 2017), heparin sodium solution and gel (Saini et al, 2018), and a combination of 2% chlorhexidine in 70% alcohol swabs for antisepsis with a spray film dressing on the catheter site (Gunasegaran et al, 2018). Meanwhile, treatment interventions included magnesium sulphate dressing (Ravindra & Krupta, 2015), glyceryl trinitrate patch (Trillo & Esteban, 2006), heparin gel (Villardell et al, 1999), diclofenac gel (Becherucci et al, 2000), sesame oil (Bigdeli Shamloo et al, 2019) and a warm compress with chamomile tea (Reis et al, 2011). A summary of the descriptive analysis of the studies is shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the evaluation of intravenous therapy‐related phlebitis, all studies used visual scales for grading phlebitis according to signs and symptoms at the catheter site. Eight studies (Bagheri‐Nesami et al, 2015; Bigdeli Shamloo et al, 2019; Gunasegaran et al, 2018; Ravindra & Krupta, 2015; Reis et al, 2011; Saini et al, 2018; Sharifi‐Ardani et al, 2017; Sheikhi et al, 2018) applied the Visual Infusion Phlebitis Scale, four studies (Becherucci et al, 2000; Çökmez et al, 2003; Trillo & Esteban, 2006; Villardell et al, 1999) created their own scale specific for the research, while one (Nekuzad et al, 2012) applied the Royal College of Nursing Phlebitis Scale. One study also evaluated pain severity using the visual analog scale (VAS) for pain (Bigdeli Shamloo et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies presented better symptom regression of intravenous therapy‐related phlebitis with treatment (Becherucci et al, 2000; Trillo & Esteban, 2006; Villardell et al, 1999). One study of sesame oil (Bigdeli Shamloo et al, 2019) demonstrated decreased local pain severity for patients with intravenous therapy‐related phlebitis in the intervention group (−6.80) versus control (−3.76). Diclofenac 1% emulsion gel resulted in a 60% (24/40) regression of symptoms of intravenous therapy‐related phlebitis versus control (20% [8/40]) (Becherucci et al, 2000), bovine heparin gel 44.3% (27/59) versus control (26.1% [17/62]) (Villardell et al, 1999) and transdermal nitroglycerin patch 80% (9/11) versus control (20% [2/11]) (Trillo & Esteban, 2006).…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Goulart

Custódio

Vasques

et al. 2020

Journal of Clinical Nursing

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Aims and objectives To evaluate the effectiveness of topical interventions in the prevention or treatment of intravenous therapy‐related phlebitis. Background Phlebitis is a severe inflammatory reaction that can be caused by intravenous therapy with hyperosmolar drugs. Although a variety of interventions are performed in several different countries, the most efficient method is yet to be established. Design A systematic review of randomised controlled trials (RCTs) was conducted. Methods Following the PRISMA checklist, we conducted a literature search using seven different databases using an individual strategy adapted for each. Studies in which any topical intervention was applied to prevent or treat intravenous therapy‐related phlebitis which were published between 1998 and 2019 were analysed. Results Data were collected of 13 RCTs, which in total collected data from 2,015 patients during hospital treatments with different types of intravenous therapies, such as fluid replacement, antibiotics, chemotherapy and antiarrhythmic drugs. The effectiveness of different topical interventions such as the application of nonsteroidal anti‐inflammatory drugs, Sesame indicum oil, heparin sodium formulations, Chamomilla recutita tea and ointment, and Rosmarinus officinalis ointment were identified. Relevance to Clinical Practice Although the studies suggest a potential to use phytotherapy agents as topical interventions, pharmaceutical preparations, main substrate, and pharmaceutical or phytotherapeutic origins are very different between studies. There are insufficient data to build a solid conclusion that lead us to recommend a specific topical intervention in the prevention or treatment of intravenous therapy‐related phlebitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Goulart

Custódio

Vasques

et al. 2020

Journal of Clinical Nursing

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“…8/11 **** DE*: 2d DR: A Bigdeli-Shamloo et al, 2019 [36] Assess the effects of topical sesame oil on reduced severity of "chemotherapy-induced phlebitis" pain.…”

Section: Quasi-experimental Studymentioning

confidence: 99%

Prevention and Treatment of Phlebitis Secondary to the Insertion of a Peripheral Venous Catheter: A Scoping Review from a Nursing Perspective

et al. 2021

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The objective of this work was to identify available evidence on nursing interventions for the prevention and treatment of phlebitis secondary to the insertion of a peripheral venous catheter. For this, a scoping systematic review was carried out following the guidelines in the PRISMA declaration of documents published between January 2015 and December 2020. The search took place between December 2020 and January 2021. Scielo, Pubmed, Medline, Scopus, WOS, CINHAL, LILACS, and Dialnet databases were consulted, and CASPe, AGREE, and HICPAC tools were used for the critical reading. A total of 52 studies were included to analyze nursing interventions for treatment and prevention. Nursing interventions to prevent phlebitis and ensure a proper catheter use included those related to the maintenance of intravenous therapy, asepsis, and choosing the dressing. With regard to the nursing interventions to treat phlebitis, these were focused on vigilance and caring and also on the use of medical treatment protocols. For the prevention of phlebitis, the highest rated evidence regarding asepsis include the topical use of >0.5% chlorhexidine preparation with 70% alcohol or 2% aqueous chlorhexidine, a proper hygienic hand washing, and the use clean gloves to handle connections and devices. Actions that promote the efficacy and safety of intravenous therapy include maintenance of venous access, infusion volume control, verification of signs of phlebitis during saline solution and medication administration, and constant monitoring. It is recommended to remove any catheter that is not essential. Once discharged from hospital, it will be necessary to warn the patient about signs of phlebitis after PVC removal.

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“…Phlebitis is an inflammation of the vein caused by chemical, mechanical, or infectious irritation (Gorski, 2017; Higginson & Parry, 2011). Several pharmacological interventions (e.g., nonsteroidal antiinflammatory drugs (NSAIDs) (Berardi et al, 2003), heparin (Ikeda, Douchi, & Nagata, 2004), steroid ointment (Hamabe et al, 2017), and traditional medicines such as Sesame indicum (Bigdeli Shamloo et al, 2019), Nigella sativa (Behnamfar, Parsa Yekta, Mojab, & Kazem Naeini, 2019), and potato (Zhang, Jin, & Wang, 2018)) have been suggested to help reduce incidence of infusion phlebitis and CIP. However, the number of evidences is limited and it is yet unknown what are the most efficient methods.…”

Section: Discussionmentioning

confidence: 99%

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

Sadoyu

Rungruang

Wattanavijitkul

et al. 2020

Phytotherapy Research

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This umbrella review aims to summarize the effects of Aloe vera on health outcomes and assess the strength of evidence. PubMed, Scopus, Embase, Cochrane database of systematic reviews, CINAHL, and AMED were searched from inception to October, 2019 for systematic reviews and meta‐analyses of clinical trials that investigated the effects of Aloe vera on health outcomes. Two independent reviewers extracted data, assessed the methodological quality, and rated the credibility of evidence according to established criteria. Ten articles reporting 71 unique outcomes of Aloe vera were included. Of these, 47 (67%) were nominally statistically significant based on random‐effects model (p ≤ .05). Only 3 outcomes were supported by highly suggestive evidence, whereas 42 outcomes were supported by weak evidence. The highly suggestive evidence supported benefits of Aloe vera in the prevention of second‐degree infusion phlebitis (RR: 0.18, 95% CI: 0.10–0.32, p‐value: 1.75 × 10−9) and chemotherapy‐induced phlebitis based on overall incidence (OR: 0.13, 95% CI: 0.08–0.20, p‐value: 9.68 × 10−20) and incidence of the second degree of severity (OR: 0.10, 95% CI: 0.07–0.14, p‐value: 3.41 × 10−35). However, the majority of the evidence were limited by small sample size and poor methodological quality. Therefore, despite the overall favorable effect of Aloe vera, more robust studies are needed.

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Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial

Cited by 21 publications

References 21 publications

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Prevention and Treatment of Phlebitis Secondary to the Insertion of a Peripheral Venous Catheter: A Scoping Review from a Nursing Perspective

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

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