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Context: Depression is a common problem during pregnancy. Depression has several adverse effects on the mother and infant. Evidence Acquisition: The present study was conducted to investigate the prevalence of depression in pregnant women in Iran. Methods: This study was performed based on the Preferred Reporting Items for systematic reviews and meta-analyses (PRISMA) guidelines. We searched the literature in the national and international databases, including Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Elsevier (Science Direct, Embase, and Scopus), Web of Science (ISI), and Google Scholar using Persian and English (MeSH) keywords. Cochran's Q test and I 2 index were used to assess the heterogeneity of the studies. A random-effects model was used to estimate the pooled prevalence using meta-analysis comprehension ver. 3. Results: 40 studies containing 15,870 Iranian pregnant women were included in the Meta-analysis. The heterogeneity of the studies was estimated to be high (I 2 = 99.70%, P < 0.001). Conclusions: According to the high prevalence of depression in Iranian pregnant woman, identification and treatment of depression during pregnancy seem essential. Thus, program designing and implementation are recommended for improving the psychological health of pregnant women.

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