Effects of topically applied agents on intra-oral wound healing in a rat model: a clinical and histomorphometric study*

Hammad, Huda M.; Hammad, Mohammad; Abdelhadi, I N; Khalifeh, Mohammad

doi:10.1111/j.1601-5037.2009.00410.x

Cited by 55 publications

(50 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyaluronan is produced during wound healing and tissue repair to provide a framework for the ingrowth of blood vessels and fibroblasts (Slevin et al 2002). Consistent with this, hyaluronan speeds up the healing of intra-oral wounds (Hammad et al 2011), promotes the adhesion and proliferation of periodontal ligament cells (Takeda et al 2011), and significantly reduces the growth of two periodontal pathogens (Rodrigues et al 2010). It also facilitates reductions in probing depth and bleeding on probing over 12 weeks following scaling and root planning (Johannsen et al 2009) and inhibits plaque growth (Rodrigues et al 2010).…”

Section: Discussionmentioning

confidence: 93%

Genome-Wide Association Study of Periodontal Health Measured by Probing Depth in Adults Ages 18−49 years

Shaffer

Polk

Wang

et al. 2014

G3 Genes|Genomes|Genetics

View full text Add to dashboard Cite

The etiology of chronic periodontitis clearly includes a heritable component. Our purpose was to perform a small exploratory genome-wide association study in adults ages 18–49 years to nominate genes associated with periodontal disease−related phenotypes for future consideration. Full-mouth periodontal pocket depth probing was performed on participants (N = 673), with affected status defined as two or more sextants with probing depths of 5.5 mm or greater. Two variations of this phenotype that differed in how missing teeth were treated were used in analysis. More than 1.2 million genetic markers across the genome were genotyped or imputed and tested for genetic association. We identified ten suggestive loci (p-value ≤ 1E-5), including genes/loci that have been previously implicated in chronic periodontitis: LAMA2, HAS2, CDH2, ESR1, and the genomic region on chromosome 14q21-22 between SOS2 and NIN. Moreover, we nominated novel loci not previously implicated in chronic periodontitis or related pathways, including the regions 3p22 near OSBPL10 (a lipid receptor implicated in hyperlipidemia), 4p15 near HSP90AB2P (a heat shock pseudogene), 11p15 near GVINP1 (a GTPase pseudogene), 14q31 near SEL1L (an intracellular transporter), and 18q12 in FHOD3 (an actin cytoskeleton regulator). Replication of these results in additional samples is needed. This is one of the first research efforts to identify genetic polymorphisms associated with chronic periodontitis-related phenotypes by the genome-wide association study approach. Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies.

show abstract

Section: Discussionmentioning

confidence: 93%

Genome-Wide Association Study of Periodontal Health Measured by Probing Depth in Adults Ages 18−49 years

Shaffer

Polk

Wang

et al. 2014

G3 Genes|Genomes|Genetics

View full text Add to dashboard Cite

show abstract

“…The substantivity of CHX is influenced by different factors, among them the concentration (13). Bioadhesive gels with higher concentrations of CHX have shown greater effectiveness in various clinical situations: periodontal treatment (14), after oral surgery procedures (15), implant dentistry (16), plaque control (17), caries prevention (18), and oral wound healing (19). Therefore, the objective of our study was to compare the effectiveness of week-long applications of CHX gel, in concentrations of 0.2% and 1%, in preventing postoperative AO after the extraction of retained mandibular third molars, as well as their impact on the patients OHRQoL.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial

Rodríguez-Pérez¹,

Bravo²,

Sánchez-López³

et al. 2013

Med Oral

View full text Add to dashboard Cite

Purpose: Alveolar osteitis (AO) is the most common postoperative complication of dental extractions. The purpose of this study was to compare the effectiveness of 1% versus 0.2% chlorhexidine (CHX) gel in reducing postoperative AO after surgical extraction of mandibular third molars, and assess the impact of treatment on the Oral HealthRelated Quality of Life (OHRQoL). Material and Methods: This clinical study was a randomized, double-blind clinical trial. Eighty eight patients underwent surgical extraction of one retained mandibular third molar with the intra-alveolar application of 0.2% CHX gel. Afterwards, they were assigned to one of two groups: 1% CHX gel (n=42) or 0.2% CHX gel (n=46). The patients applied the gel twice a day to the wound for one week. All patients were evaluated for AO. Results: In the 0.2% CHX gel group, 13% of AO incidence was found, while in the 1% CHX gel group, AO incidence was 7%, a difference that was not statistically significant. Variables such as sensation of pain and inflammation at baseline and during one week, as well as OHRQoL of the patients at 24 hours and 7 days post-extraction, gave no statistically significant differences. Conclusions: There are no significant differences in AO after surgical extraction of mandibular third molars, when comparing applying 1% CHX gel twice a day for 7 days with 0.2% CHX gel. Key words:Alveolar osteitis, chlorhexidine gel, third molar.

show abstract

“…None of the tested agents were shown to adversely affect wound healing. The best results were obtained in the groups in which 0.2% chlorhexidine and hyaluronic acid were applied (24). …”

Section: Discussionmentioning

confidence: 99%

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

Madrazo-Jiménez¹,

Rodríguez-Caballero²,

Serrera-Figallo³

et al. 2016

Med Oral

View full text Add to dashboard Cite

BackgroundDespite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar.Material and MethodsA split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel.ResultsThe groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups.ConclusionsThe gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. Key words:Impacted lower third molar, postoperative wound healing, chitosan, chlorhexidine, allantoin, dexpanthenol, postoperative period.

show abstract

Effects of topically applied agents on intra-oral wound healing in a rat model: a clinical and histomorphometric study*

Abstract: None of the tested agents had a negative effect on the rate of wound healing when applied on an excisional wound with epithelial and connective tissue defect. Positive results were achieved with Perio.Kin® and Gengigel®.

Cited by 55 publications

References 42 publications

Genome-Wide Association Study of Periodontal Health Measured by Probing Depth in Adults Ages 18−49 years

Genome-Wide Association Study of Periodontal Health Measured by Probing Depth in Adults Ages 18−49 years

Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

Contact Info

Product

Resources

About