Effects of total flavonoids of raspberry on perimenopausal model in mice

Abstract

To study the effect of raspberry total flavonoids on perimenopausal model in mice. Blank group, sham operation, and the rest of the mice made the menopausal model. Choose 72 mice castrated completely random divided into 6 groups for the experiment, respectively: model group, gengnianan (GNA) capsule group, soybean isoflavone soft (SIS) capsule group, high, mid and low dose group of total flavonoids of raspberry (TFR). Animals in each group were given the corresponding drugs tenth days after operation, and were given intragastrical administration of once a day for continuous administration of 21 days. Each group of mice in the administration of 18 days to determine the number of autonomic activities within 5 min, in the administration of 19-20 days to determine the incubation of the mice first entry into the darkroom and the number of shocks into the darkroom within 5 min. At 2 h after the last administration (fasting for 12 h), mice were sacrificed and serum was collected. Serum levels of E2, T, LH and FSH were measured. Dissect the uterus, uterus, thymus and spleen. Weigh the wet weight and calculate the organ index, the morphological changes of uterus, thymus and spleen were observed. The results showed that the TFR had a good therapeutic effect on the perimenopausal model of mice after giving a high, mid and low dose of raspberry flavonoids for some time.

Effect of liquiritin on neuroendocrine‐immune network in menopausal rat model

“…90% of estrogen in females is secreted by the ovaries, and the ovariectomy artificially causes a sudden drop in estrogen levels, which then causes menopausal syndrome (Fu et al, 2017). OFT showed that OVX rats have reduced activity and curiosity about the fresh environment.…”

“…The ovariectomized animal model is a classic model with a high success rate and has been widely used in menopause studies, although it is still insufficient for human peri‐menopausal simulations. 90% of estrogen in females is secreted by the ovaries, and the ovariectomy artificially causes a sudden drop in estrogen levels, which then causes menopausal syndrome (Fu et al, 2017). OFT showed that OVX rats have reduced activity and curiosity about the fresh environment.…”

“…Perimenopause, which is a necessary stage in woman's life, is a transitional period from the reproductive age of women to the elderly, often occurs between 45 and 55 years old (Fu, Wei, & Miao, 2017). As the average life expectancy of humans in developed countries increases to about 80 years and menopause occurs at a relatively fixed age, many women will spend more than a third of their lives in postmenopausal state.…”

Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG

“…In view of this phenomenon, it is proposed to use kidney-tonifying Yang medicine to treat gynecological diseases. Based on different animal models to confirm the curative effect of kidney-tonifying Yang medicine commonly used in clinical prescription, it has been found that Chinese medicine for kidney-yang has significant effects on perimenopausal syndrome (Fu et al, 2018), perimenopausal depression (Liu et al, 2012), uterine dysplasia and dysmenorrhea. Dodder is a kind of traditional Chinese medicine commonly used for kidney-tonifying, which has many pharmacological effects, such as regulating immunity, anti-aging, protecting liver, regulating reproductive system, protecting cardiovascular and cerebrovascular, lowering blood glucose.…”

Microwave-Assisted Enzymatic Extraction of Flavonoids from Armeniaca mume Sieb. Blossom and Their Immunomodulating Effect in Mice with DSS-Induced Colitis

“…Spleens and thymuses of mice were collected and weighed. The spleen and thymus indices were calculated using Equation (2) [19].…”