Effects of Total Parenteral Nutrition Using a Solution Enriched with Branched-Chain Amino Acids on Experimental Pancreatitis in Rats

Abstract

The main purpose of this study was to investigate the influence of total parenteral nutrition enriched with branched-chain amino acids (BCAA) on acute pancreatitis (AP) induced by sodium taurocholate in rats. Total parenteral nutrition (TPN) increased the survival rate and serum calcium, and reduced serum urea, liver transaminase, acid phosphatase and lactate dehydrogenase levels, but it did not change the degree of pancreatic damage or serum amylase. Total plasma amino acid concentration and the concentrations of glutamate, glycine, alanine, taurine, valine, leucine, isoleucine, phenylalanine increased significantly after the induction of AP, but there was no difference between the control and therapy groups. Hyperglycemia occurred during the use of TPN. BCAA-enriched TPN can be used in the treatment of AP with few side effects.

Effects of Combined Nutritional Therapy on Acute Necrotizing Pancreatitis in Rats in the Early Phase of the Disease

“…Liver abnormalities and hyperglycemia may also occur due to TPN alone [19,33]. We observed hyperglycemia and increased levels of ALT in CNT groups similar to other studies [8,9,19,33]. These results indicate that the use of CNT during ANP causes metabolic complications.…”

“…Severe parenchymal damage has been reported in the liver, lungs, kidneys and heart in bile-induced pancreatitis [2,8,9]. Liver abnormalities and hyperglycemia may also occur due to TPN alone [19,33].…”

“…In severely affected patients who are hypercatabolic, it is logical to begin artificial nutrition. However, the route of nutritional support (enteral versus parenteral), time (early versus late), composition of substrates administered and its combination with somatostatin remain controversial [7][8][9]. Although the parenteral route for nutritional support improves the nutritional status of the patients, it can be complicated by bacterial translocation leading to systemic inflammatory response syndrome [10].…”