Effects of training and anabolic steroids on collagen synthesis in dog heart

Takala, Timo; Rämö, P.; Kiviluoma, Kai; Vihko, V.; Kainulainen, Heikki; Kettunen, Raimo

doi:10.1007/bf00635624

Cited by 34 publications

(26 citation statements)

References 40 publications

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“…Although sudden death of unknown origin is sometimes reported, it is possible that this may be due to AAS-induced cardiac damage. In light of our current findings, and those in previous reports regarding the serious deleterious effects of AAS on the myocardium, this is a logical conclusion [37][38][39][40]. Furthermore Marsh et al reported that androgen receptors were present in cardiac muscle [41].…”

Section: Discussionsupporting

confidence: 59%

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

2004

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Abstract. Many athletes use drugs, especially anabolic androgenic steroids (AAS), but there are few reports on the endocrinological and pathological changes in AAS abusers. In this study we reported the results of endocrinological examinations in rats administered AAS and also physical changes. We separated 37 male Wistar rats (7 weeks old) into 3 groups: Group A was medicated with nandrolone decanoate, metenolone acetate, and dromostanolone; Group B with nandrolone decanoate and saline; and Group C was given only saline. They were given subcutaneous injections of the medications or the control vehicle once a week for 6 weeks. Medications were stopped for 4 weeks, and then resumed for another 6 weeks. After that, rats were sacrificed. Serum testosterone level in Group A was significantly higher than that in Group C. Serum dihydrotestosterone in Group A was significantly higher than that in both Groups B and C. Serum estradiol-17b levels in Groups A and B were significantly higher than that in Group C. In pathological evaluation, heart, testis, and adrenal gland were severely damaged. These findings indicate that there is a high degree of risk related to the use of AAS.

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Section: Discussionsupporting

confidence: 59%

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

2004

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“…Both running training (Burgess et al 1996) and swimming training (Medugorac and Jacob 1983) are unable to alter myocardial collagen types I/III. Similarly, many studies demonstrate that myocardial collagen concentrations remain unchanged following exercise programmes (Burgess et al 1996;Kiiskinen and Heikkinen 1976;Medugorac 1980;Takala et al 1991;Tomanek et al 1972). In contrast, Hickson et al (1979) and Masumura et al (1983) showed that a decrease in myocardial total hydroxyproline concentration occurs following an exercise programme.…”

Section: Discussionmentioning

confidence: 87%

Reduced cardiac stiffness following exercise is associated with preserved myocardial collagen characteristics in the rat

Woodiwiss

Oosthuyse

Norton

1998

European Journal of Applied Physiology

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We determined whether the increment in cardiac end-diastolic compliance (a reduced diastolic stiffness constant) following endurance training is related to alterations in myocardial collagen characteristics. Sixteen weeks of habitual exercise (Ex) in rats, which produced left ventricular (LV) hypertrophy (LVH) [LV weight in g: Ex = 1.01 (0.04), sedentary control = 0.89 (0.04); P < 0.05], resulted in a reduced LV end-diastolic (LVED) chamber stiffness [slope of the linearised LVED pressure versus LVED internal diameter relation in kPa x mm(-1): Ex = 0.67 (0.03), control = 0.80 (0.03); P < 0.05]. The increased LVED chamber distensibility was associated with an attenuated myocardial stiffness [slope of the linearised LVED stress versus strain relation in g x cm(-2); Ex= 15 (3), control = 25 (2); P < 0.05]. Although LV total collagen content (mg) was increased in the exercised rats [Ex = 5.0 (0.3), control = 4.1 (0.2); P < 0.05], this was a reflection of the presence of LVH, as the myocardial collagen concentration (microg x mg(-1) LV wet weight) was unaltered [Ex = 4.9 (0.2), control = 4.6 (0.2)]. Furthermore, habitual exercise did not influence the percentage of myocardial collagen extracted following cyanogen bromide digestion (an index of collagen cross-linking), [i.e. Ex = 38 (3), control = 38 (3)], nor the proportion of myocardial collagen phenotypes I and III [I/III; Ex = 3.04 (0.20), control = 2.85 (0.22)]. In conclusion, exercise-induced increments in end-diastolic myocardial distensibility are unlikely to be a consequence of alterations in the properties of myocardial collagen.

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“…Endurance training caused physiological hypertrophy of the left ventricle in the cardiovascular system of humans, which was associated with increase of the cavity diameter (5) , while resistance training produced concentric hypertrophy (6) . AAS reduced complacence of the left ventricle with no alteration in the cardiac contrality of rats (7) , and their simultaneous administration with training increased collagen concentration on the wall of the right ventricle in dogs (8) . Physical training is known to be an efficient means used in the regulation of the blood pressure (BP) and peripheral vascular resistance (9) , while the treatment with nandrolone decanoate may reduce reactivity of the thoracic aorta in rabbits (10) .…”

Section: Introductionmentioning

confidence: 99%

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares

Abreu

Assenço

et al. 2011

Rev Bras Med Esporte

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Anabolic androgen steroids (AASs) are drugs synthesized from testosterone. Their anabolic action is mainly due to increased synthesis and reduced degradation of muscle proteins. The purpose of this study was to investigate the effects of swimming training associated to nandrolonedecanoate treatment on the blood pressure, the myocardial dimensions, vascular reactivity. Forty Wistar male rats, aged 60 days, were divided into 4 groups (n = 10): sedentary (SN), sedentary treated (ST), trained (TN) and trained treated (TT). TN and TT animals performed a swimming training during 12 weeks and ST and TT animals received weekly nandrolonedecanoate (15mg/kg). The heart and testicles were removed and weighted. The left ventricular diameter (LVD) and left ventricular wall thickness (LVWT) had been measured with an electronic pachymeter. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was weekly measured, while the mesenteric arteries vascular reactivity was studied for its response to noradrenaline. There were no alterations in the heart weight, but the LVD increased (p < 0.05) in TN rats, while the LVWT increased (p < 0.05) in ST and TT rats, both in relation to SN. Testicle weight decreased (p < 0.05) in the ST and TT animals in relation to SN. There was no alteration in blood pressure, neither in vascular reactivity. It was concluded that swimming training increased the left ventricular diameter, while nandrolonedecanoate treatment increased mainly the left ventricular wall thickness, suggesting concentric hypertrophy.

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Effects of training and anabolic steroids on collagen synthesis in dog heart

Cited by 34 publications

References 40 publications

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

Endocrinological and Pathological Effects of Anabolic-androgenic Steroid in Male Rats

Reduced cardiac stiffness following exercise is associated with preserved myocardial collagen characteristics in the rat

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

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