Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: Toward overcoming a genetic deficit

Escorihuela, Rosa M.; Tobeña, Adolf; Driscoll, Peter; Fernández-Teruel, Albert

doi:10.1016/0149-7634(94)00051-2

Cited by 77 publications

(42 citation statements)

References 76 publications

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“…Two phenotypes with different emotional and motivational profiles have been developed through bidirectional selection and breeding of the Roman high-(RHA) and low-avoidance (RLA) rat lines/ strains (outbred or inbred, respectively), selected for rapid (RHA) vs extremely poor (RLA) acquisition of two-way active avoidance in the shuttle-box (Broadhurst and Bignami, 1965;Driscoll and Bättig, 1982) (for reviews, see Driscoll et al, 1990Driscoll et al, , 1998Driscoll et al, , 2009Escorihuela et al, 1995Escorihuela et al, , 1999Fernández-Teruel et al, 1997;Giorgi et al, 2007;Steimer and Driscoll, 2005). These lines/strains show consistent differences in sensation/novelty seeking and in stress/anxiety endocrine and behavioral responses when confronted with novel environments (ie, intended to measure anxiety, emotionality, fearfulness, or novelty seeking), such as the open-field test (Aubry et al, 1995;Carrasco et al, 2008;Escorihuela et al, 1999;Gentsch et al, 1991), elevated plus maze (Escorihuela et al, 1999;Steimer and Driscoll, 2003), elevated zero-maze (López-Aumatell et al, 2009b), blackwhite box test, dark-light open-field test, dark-light hexagonal tunnel maze (Fernández-Teruel et al, 2002b;Steimer and Driscoll, 2005), and hole-board test (Escorihuela et al, 1999;Fernández-Teruel et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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Section: Introductionmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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“…In the shuttle box, RHA/Verh rats quickly acquire the active avoidance response, whereas RLA/Verh rats display much freezing and escape responses during the acquisition phase (Driscoll and Battig 1982;Escorihuela et al 1995;Fernandez-Teruel et al 1997). Results from other models of anxiety (the open field, elevated plus maze, and light-dark box and freezing to a conditioned stimulus) concur: Both inbred and outbred RHA/Verh rats are less anxious than their inbred or outbred RLA/Verh counterparts (Steimer et al 1997;Driscoll et al 1998;Escorihuela et al 1999).…”

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confidence: 99%

A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat

Fernández-Teruel¹,

Escorihuela²,

Gray³

et al. 2002

Genome Res.

134

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A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking. The limited behavioral test regimes so far used in genetic mapping experiments and the lack of suitable multivariate methodologies have made it impossible to determine whether the quantitative trait loci (QTL) detected to date specifically influence fear-related traits. Here we report the first multivariate analysis to explore the genetic architecture of rodent behavior in a battery of animal models of anxiety. We have mapped QTLs in an F2 intercross of two rat strains, the Roman high and low avoidance rats, that have been selectively bred for differential response to fear. Multivariate analyses show that one locus, on rat chromosome 5, influences behavior in different models of anxiety. The QTL influences two-way active avoidance, conditioned fear, elevated plus maze, and open field activity but not acoustic startle response or defecation in a novel environment. The direction of effects of the QTL alleles and a coincidence between the behavioral profiles of anxiolytic drug and genetic action are consistent with the QTL containing at least one gene with a pleiotropic action on fear responses. As the neural basis of fear is conserved across species, we suggest that the QTL may have relevance to trait anxiety in humans.

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“…Differences in sensitivity to various stressors between the RHA/Verh and RLA/Verh rats have been observed in a number of studies (Driscoll and Battig, 1982;Driscoll et al, 1990;Escorihuela et al, 1995). For example, RHA/Verh rats are generally more active in various novel environments and show a smaller stressor-induced increase in ACTH as well as corticosterone, prolactin, and other hormones than do RLA/Verh rats (Aubry et al, 1995;Castanon et al, 1995;Gentsch et al, 1981Gentsch et al, , 1982Walker et al, 1989).…”

Section: Discussionmentioning

confidence: 96%

Differential Effects of CRH Infusion Into the Central Nucleus of the Amygdala in the Roman High-Avoidance and Low-Avoidance Rats

Wiersma

Konsman

Knollema

et al. 1998

Psychoneuroendocrinology

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Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: Toward overcoming a genetic deficit

Cited by 77 publications

References 76 publications

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat

Differential Effects of CRH Infusion Into the Central Nucleus of the Amygdala in the Roman High-Avoidance and Low-Avoidance Rats

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