Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy

Teixeira, Renata Cr; Monteiro, Eduardo Raposo; Campagnol, Daniela; Coelho, Karina; Bressan, Thaís Feres; Monteiro, Betânia Souza

doi:10.1111/vaa.12080

Cited by 60 publications

(45 citation statements)

References 20 publications

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“…One limitation of our study was the relatively small number of dogs in each group, although it was consistent with sample size of similar studies reported in the literature (Lemke et al, 2002;Teixeira et al, 2013aTeixeira et al, , 2013b; standardisation of procedures were undertaken as were assessments of parameters considered optimal for a clinical study.…”

Section: Discussionmentioning

confidence: 85%

Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

Guerrero

Schwarz

Wuhrmann

et al. 2015

The Veterinary Journal

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Section: Discussionmentioning

confidence: 85%

Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

Guerrero

Schwarz

Wuhrmann

et al. 2015

The Veterinary Journal

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“…in dogs undergoing ovariohysterectomy (Mastrocinque and Fantoni 2003). In addition, increasing the dose of tramadol or combining it with other analgesics such as dipyrone or meloxicam can produce a good analgesic effect for 24 h, as evaluated by the CMPS-SF or the VAS (Teixeira et al 2013). In our study, dogs receiving 1 mg/kg nefopam i.v.…”

Section: Discussionmentioning

confidence: 95%

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Zhang¹,

Li²,

Luan³

et al. 2017

Vet. Med. - Czech

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Relieving perioperative pain can reduce postoperative suffering and improve recovery from anaesthesia in animals. The aim of this study was to compare the analgesic effects of nefopam and tramadol in dogs undergoing ovariohysterectomy. Twenty-four adult mixed-breed female dogs were randomly divided into three groups (n = 8) and received their respective treatments immediately after surgery: Group T (2 mg/kg tramadol, i.v.), Group C (1 mg/kg nefopam, i.v.) and Group D (2 mg/kg nefopam, i.v.). The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured and the level of analgesia was assessed using the Glasgow Composite Measure Pain Scale (CMPS-SF). The CMPS-SF was performed at least two days before premedication (baseline), every 2 h for the first 8 h (post-extubation), at 12 h and at 24 h. Results showed that the HR in all groups was significantly (P < 0.05) higher at 2 and 6 h than at baseline. The RR in Group T was significantly higher (P < 0.05) at 0 and 2 h than at baseline. Rescue analgesia (0.2 mg/kg morphine, i.v.) was provided if CMPS-SF pain scores greater than or equal to six. Four dogs required rescue analgesia: one dog in Group T at 2 h and three dogs in Group C at 2 and 6 h. No dogs in Group D required rescue analgesia. The CMPS-SF pain scores of dogs in Group C were significantly higher (P < 0.05) than those in Group T at 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group C at 2, 4, 6, 8 and 12 h. The scores in Group D were significantly lower (P < 0.05) than those in Group T at 2 and 4 h. However, the scores in Group D were not significantly different compared with Group T. In conclusion, this study suggests that nefopam at 2 mg/kg i.v. produces better postoperative analgesia compared with tramadol at 2 mg/kg i.v. or nefopam at 1 mg/kg i.v. in dogs undergoing ovariohysterectomy.

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“…16 The injectable form of the drug has been shown to provide adequate analgesia in dogs experiencing mild to moderate levels of pain. 17,18 In cats undergoing ovariohysterectomy, injectable tramadol combined with an NSAID provided adequate analgesia 19 and oral administration increased thermal thresholds. 20 Side effects of tramadol administration include bradycardia, nausea, and constipation or diarrhea.…”

Section: Tramadol and Tapentadolmentioning

confidence: 99%

Analgesia in the Perioperative Period

Berry

2015

Veterinary Clinics of North America: Small Animal Practice

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Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy

Cited by 60 publications

References 20 publications

Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

Analgesia in the Perioperative Period

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