Effects of transcallosal surgery on interhemispheric transfer of information

Levin, Harvey S.; Mattson, Audrey J.; Levander, Maria; Lindquist, Christer; Simard, J. Marc; Guinto, Faustino C.; Lilly, Matthew A.; Eisenberg, Howard M.

doi:10.1016/0090-3019(93)90174-y

Cited by 29 publications

(12 citation statements)

References 13 publications

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“…1989), while patients performed better when the resection extensively involved other regions of the commissure but spared the posterior body (Risse et al . 1989; Levin et al . 1993; see also Dimond et al .…”

Section: Discussionmentioning

confidence: 99%

“…Similar results have been obtained in more recent studies of partially callosotomized patients in whom the extent of the resection was veri®ed in vivo with MRI. Severe impairment in tactile naming has been observed when the lesion included the posterior third of the body of the callosum (Risse et al, 1989), while patients performed better when the resection extensively involved other regions of the commissure but spared the posterior body (Risse et al, 1989;Levin et al, 1993; see also Dimond et al, 1977;Damasio et al, 1980;Meyer et al, 1998). At variance with these results, one study reported a high level performance in tactile naming in patients with section of the caudal part of the body of the callosum (Bentin et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…Pre-and postoperatively, all patients but one (RF) were submitted to the tactile naming test to evaluate their ability to name a series of objects presented to the left and right hand out of view. Twelve common objects, whose nature was unknown to the patients, were presented randomly to each hand and patients were required to name them correctly (Bentin et al, 1984;Risse et al, 1989;La Ádavas et al, 1993;Levin et al, 1993;Aglioti et al, 1998). To avoid possible cross-cueing from noise, objects were placed on a soft board.…”

Section: Tactile Naming Testmentioning

confidence: 99%

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Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

Fabri

Polonara

Quattrini

et al. 1999

Eur J of Neuroscience

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To verify whether the activation of the posterior parietal and parietal opercular cortices to tactile stimulation of the ipsilateral hand is mediated by the corpus callosum, a functional magnetic resonance imaging (fMRI, 1.0 tesla) study was performed in 12 control and 12 callosotomized subjects (three with total and nine with partial resection). Eleven patients were also submitted to the tactile naming test. In all subjects, unilateral tactile stimulation provoked a signal increase temporally correlated with the stimulus in three cortical regions of the contralateral hemisphere. One corresponded to the first somatosensory area, the second was in the posterior parietal cortex, and the third in the parietal opercular cortex. In controls, activation was also observed in the ipsilateral posterior parietal and parietal opercular cortices, in regions anatomically corresponding to those activated contralaterally. In callosotomized subjects, activation in the ipsilateral hemisphere was observed only in two patients with splenium and posterior body intact. These two patients and another four with the entire splenium and variable portions of the posterior body unsectioned named objects explored with the right and left hand without errors. This ability was impaired in the other patients. The present physiological and anatomical data indicate that in humans activation of the posterior parietal and parietal opercular cortices in the hemisphere ipsilateral to the stimulated hand is mediated by the corpus callosum, and that the commissural fibres involved probably cross the midline in the posterior third of its body.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tactile Naming Testmentioning

confidence: 99%

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Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

Fabri

Polonara

Quattrini

et al. 1999

Eur J of Neuroscience

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“…Furthermore, a series of studies using Poffenberger's visuo-motor reaction time paradigm (1912) revealed that interhemispheric transmission is asymmetric (e.g. Levin et al 1993), or from research on transfer of distal single-joint motor commands (Iacoboni and Zaidel 1995). While our conclusions are based on intermanual transfer of a distal multi-joint motor skill, transcaUosal facilitation was inferred from studies on intermanual transfer of more complex tasks involving problem-solving strategies, i.e., form-board (e.g.…”

Section: Discussionmentioning

confidence: 99%

What is the role of the corpus callosum in intermanual transfer of motor skills? A study of three cases with callosal pathology

et al. 1997

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Intermanual transfer for a skilled motor task was studied in two patients with total callosal agenesis, and one with an acquired partial callosal lesion and clinical evidence for disturbed transfer of motor signals. Patients had to draw meaningless figures with one upper extremity (original learning, OL) and to reproduce their mirror-reversals thereafter with the other side (transfer learning, TL). Both directions of intermanual transfer were tested in two conditions, that is, between either proximal or distal muscle groups. Transfer was evaluated by comparing OL and TL performance at the same effector. The main variable of interest was movement time during the first eight trials of OL and TL. All three patients displayed a significant benefit for transfer from the dominant to the non-dominant hand but not vice versa during proximal motor activity. When compared with the performance of healthy subjects tested in almost identical conditions in a previously reported study, the proximal transfer behavior was found to be similar for all patients and the normal group. Although patients exhibited no significant benefit for distal transfer, their non-dominant-to-dominant distal transfer was above the normal range. The similar transfer pattern of the patients and healthy subjects when using proximal musculature suggests that proximal transfer may be subserved by identical extracallosal pathways, most probably by the ipsilaterally descending motor systems. Since non-dominant-to-dominant distal transfer was found to be disadvantageous in healthy subjects, the patients' relative superiority in this condition may reflect missing callosal influences of an inhibitory nature.

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“…2,9,11,12,41 Limited callosal sectioning may cause changes in transfer of tactile data that can be detected with special neuropsychological testing, but this does not seem to cause any deficit that can be noticed by the patients in normal life. 24,27 In previous reports, however, transcallosal surgery for colloid cyst has produced significant morbidity. Permanent memory deficit and/or venous infarction were reported in 24% of patients.…”

Section: Microsurgery and Memory Impairment From Forniceal Tractionmentioning

confidence: 98%

Third ventricle colloid cysts: a consecutive 12-year series

Mathiesen

Grane²,

Lindgren³

et al. 1997

Journal of Neurosurgery

149

110

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A continuous follow-up review of colloid cysts including aspects of natural history and evaluation of treatment options is necessary to optimize individual treatment. Thirty-seven consecutive patients with colloid cyst of the third ventricle seen at Karolinska Hospital between 1984 and 1995 were reviewed. Five patients were admitted in a comatose state, and two died despite emergency ventriculostomy. Three had recurrent cysts following previous aspiration procedure. During the study period, patients underwent a total of 10 ventriculostomies, 10 aspirations, 26 microsurgical operations, and two shunt operations. Twenty-four of 26 microsurgical operations were transcallosal and two were transcortical. Twenty-four operations (22 transcallosal and two transfrontal approaches) without permanent morbidity were performed by four surgeons. Transient memory deficit from forniceal traction was noted in 26%. The remaining two transcallosal operations, which led to permanent morbidity or mortality, were performed by two different surgeons. Aspiration of cysts performed by four different surgeons carried a 40% risk of transient memory deficit (10% permanent) and an 80% recurrence rate. One patient was found to be cured on radiological studies obtained at the 5-year follow-up review. Seven cysts were followed by means of radiological studies with no treatment for 6 to 37 months. Five of these cysts grew, indicating that younger patients with colloid cysts will probably need surgical treatment. The main causes of unfavorable results were: 1) failure to investigate symptoms that proved fatal; 2) subtotal resection; and 3) surgical complications. Transcallosal microsurgery produced excellent results when performed by experienced surgeons. A colloid cyst of the foramen of Monro is a disease that should be detected before permanent neurological damage has occurred. Permanent morbidity or mortality should not be accepted in modern series of third ventricle colloid cysts.

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Effects of transcallosal surgery on interhemispheric transfer of information

Cited by 29 publications

References 13 publications

Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

What is the role of the corpus callosum in intermanual transfer of motor skills? A study of three cases with callosal pathology

Third ventricle colloid cysts: a consecutive 12-year series

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