Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats

Martino‐Andrade, Anderson Joel; Morais, Rosana Nogueira de; Spercoski, Katherinne Maria; Rossi, Stéfani Cibele; Vechi, Marina F.; Golin, Munisa; Lombardi, Natália Fracaro; Greca, Cláudio S.; Dalsenter, Paulo Roberto

doi:10.1016/j.jep.2009.09.031

Cited by 70 publications

(59 citation statements)

References 22 publications

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“…Researchers have shown that T. terrestris extract increases sexual potency in men by increasing level of free testosterone and regulating the amount of estrogen, progesterone and pregnenolone (Ghosian Moghaddam et al, 2013). Further, the use of the plant in traditional medicine in India and China is to treat sexual dysfunction and increase libido by increasing the level of testosterone and LH (Martino-Andrade et al, 2010;Park et al, 2006). However, a study has shown that T. terrestris had no effect on the organs such as the prostate, seminal vesicles, uterus and vagina that are sensitive to endocrine system (Martino-Andrade et al).…”

Section: Introductionmentioning

confidence: 99%

Tribulus terrestris Hydroalcoholic Extract Administration Effects on Reproductive Parameters and Serum Level of Glucose in Diabetic Male Rats

et al. 2016

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GHANBARI, A.; MORADI, M.; RAOOFI, A.; FALAHI, M. & SEYDI, S.Tribulus terrestris hydroalcoholic extract administration effects on reproductive parameters and serum level of glucose in diabetic male rats. Int. J. Morphol.,34(2):796-803, 2016. SUMMARY:Usage of medicinal plants for the treatment of diseases is a remarkable strategy considered in both clinical and experimental studies. This study was conducted to evaluate the effect of Tribulus terrestris hydroalcoholic extract administration on the serum level of glucose and reproductive parameters in diabetic male rats. In this experimental study, 30 adult male Wistar rats (200-250 g) were divided into 5 groups (n= 6). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin. Experimental groups received daily Intraperitoneal injection of the extract (100, 250 and 500 mg/kg) since one week after inducing diabetes for two weeks. At the end of the experiment, the serum levels of testosterone and glucose were examined by ELISA and Glucodr devices respectively. Sperm parameters including morphology, count and motility were evaluated from the cauda epididymis. The diameters of seminiferous tubules were assessed based on 5 µm paraffin section of H&E stained section of testes. The data were evaluated by One Way ANOVA followed by post-hoc test using SPSS software. In T. terrestris extract groups, there were significant reductions in the levels of blood glucose while increased sperm motility, sperm count and seminiferous tubules diameter, percentage of sperms with normal morphology, level of testosterone hormone and final body weight compared with diabetic group (p <0.001). In conclusion, T. terrestris hydroalcoholic extract decreases serum level of glucose and diminishes the side effects of diabetes on male reproductive system showing by increasing in the serum level of testosterone, improving sperm parameters and returning the seminiferous tubules to normal diameter by a dose dependent manner.

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Section: Introductionmentioning

confidence: 99%

Tribulus terrestris Hydroalcoholic Extract Administration Effects on Reproductive Parameters and Serum Level of Glucose in Diabetic Male Rats

et al. 2016

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“…A fall in TRC and TL on subsequent exposures to the Hebb William Maze and the T maze respectively, was taken as an index of successful retention [9] . In the study done by Martino Andrade AJ et al, Tribulus terrestris was used at a dose of 11, 42 and 110mg/kg/day and was unable to stimulate the endocrine sensitive tissues like prostate, seminal vesicle, uterus and vagina [5] . Another study, done by Jungmo Do et al, Tribulus terrestris showed a dose dependent increase in the Intracavernous Pressure after being administered for one month at a dose of 2.5, 5, 10, 50 and 100mg/kg in rabbits, thus demonstrating its use as a potential agent for erectile dysfunction [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Tribulosin, a methanolic extract of Tribulus terrestris protects rat heart from ischemia/perfusion injury [4] . Despite its aphrodisiac activity, it has shown no effect on endocrine sensitive tissues like prostrate, seminal vesicle, uterus and vagina in wistar rat pointing to the lack of androgenic and estrogenic activity in vivo [5] .…”

Section: Introductionmentioning

confidence: 96%

Effect of Tribulus Terrestris on Learning and Memory in Wistar Rats

Prabhu¹,

Hadigal²,

D³

et al. 2014

Phcog J.

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Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received Tribulus terrestris orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. Results: Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p<0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p<0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group. Conclusions: The aqueous extract of fruits of Tribulus terrestris showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.

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“…A limited number of animal studies have found that TT significantly increases testosterone levels. For example, two of three recent studies utilizing Wistar rats found serum testosterone levels to be significantly increased following varying dosages of TT taken once daily [42,123,124]. Martino-Andrale et al found no significant increase in serum testosterone levels but supplemented the wistar rats with the lowest level of TT between the three studies [124], suggesting that dosing is a factor in achieving desired outcomes.…”

mentioning

confidence: 99%

“…For example, two of three recent studies utilizing Wistar rats found serum testosterone levels to be significantly increased following varying dosages of TT taken once daily [42,123,124]. Martino-Andrale et al found no significant increase in serum testosterone levels but supplemented the wistar rats with the lowest level of TT between the three studies [124], suggesting that dosing is a factor in achieving desired outcomes. An additional study investigated the effects of TT supplementation in primates (n = 5), white rabbits (n = 24), and Sprague-Dawley rats (n = 40) both before and after treatment [125], noting a significant increase in testosterone in primates but not in white rabbits or rats.…”

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confidence: 99%

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Low circulating testosterone levels can present numerous problems related to the overall health and well-being of individuals, men in particular. This finding is well-documented in the literature and low testosterone appears more prevalent in older men, in particular those who are physically inactive and who present with elevated levels of body fat. Multiple botanical (herbal) products have been claimed to elevate circulating testosterone in men; however, data pertaining to the use of such herbal preparations obtained from human clinical trials are limited. This review examines the research to date pertaining to the use of herbal ingredients with regards to their ability to elevate blood testosterone levels. A collective summary of the findings indicate that certain herbal supplements may actually yield an increase in testosterone (e.g., Longjack root), while most others have little to no evidence in support of their use in human subjects. Additional, well-controlled clinical trials are needed to generate data relative to the use of herbal dietary supplements to increase circulating testosterone. Testosterone is generally measured as either "free" (unbound) or "total" (unbound and chemically bound). Men who have a morning serum testosterone level < 300 ng/dL are considered to be "low" and may be a candidate for testosterone replacement therapy-which has become more common in recent years due to the increased diagnosis of andropause [55]. Insufficient levels of testosterone due to either impaired production or uptake can present serious health consequences due to the wide array of applications of testosterone within the human body. Areas including skeletal muscle health, muscular strength, and overall well-being/vitality seem to be significantly affected by testosterone status. Increasing Circulating Testosterone: Impact of Herbal Dietary SupplementsTrintThe role of testosterone in muscle growth has been investigated extensively in both humans and animals [56][57][58][59][60][61][62]. One study in men concluded that the testosterone-induced increase in muscle volume is due to muscle fiber hypertrophy [63]. A follow-up study conducted a year later noted muscle hypertrophy in men over a period of 20 weeks of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of testosterone enanthate. The main findings from this study indicated that testosterone administration was associated with a significant increase in myonuclear number in men receiving the 300-and 600-mg doses.Muscular strength is another important factor that has been shown to be affected by testosterone levels in the body [56,61,62,[64][65][66]. A recent investigation utilized 267 men with stages 2-4 of Chronic Kidney Disease to assess the impact of testosterone level on a variety of variables [64]. This study found that testosterone was significantly and independently associated with handgrip strength, muscle mass, and nutritional status as the disease progressed. Another study explored short-term testoste...

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Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats

Cited by 70 publications

References 22 publications

Tribulus terrestris Hydroalcoholic Extract Administration Effects on Reproductive Parameters and Serum Level of Glucose in Diabetic Male Rats

Tribulus terrestris Hydroalcoholic Extract Administration Effects on Reproductive Parameters and Serum Level of Glucose in Diabetic Male Rats

Effect of Tribulus Terrestris on Learning and Memory in Wistar Rats

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

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