Effects of Tumor Necrosis Factor Alpha Antagonist, Platelet Activating Factor Antagonist, and Nitric Oxide Synthase Inhibitor on Experimental Otitis Media with Effusion

Kim, Dong-Hyun; Park, Yong Soo; Jeon, Eun-Ju; Yeo, Sang-Won; Chang, Ki‐Hong; Lee, Seung Kyun

doi:10.1177/000348940611500808

Cited by 14 publications

(11 citation statements)

References 18 publications

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“…Although the antiinflammatory and antifibrotic effects of L-NAME were shown in various studies regarding wound healing processes of different tissues [10][11][12]14], to our knowledge, this is the first study to evaluate the effects of L-NAME for the prevention of MS.…”

Section: Discussionmentioning

confidence: 99%

“…Neuronal NOS (nNOS), serves as a neurotransmitter. The third isoform inducible NOS (iNOS) mainly presents in pathophysiological conditions such as inflammation and it produces NO at levels approximately 1000 times greater than either eNOS or nNOS [10,15]. NO reacts with free radicals and plays an important role in the excessive inflammatory response seen in the early phase of the inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Another way to reduce the formation of peroxynitrite is to suppress NOS by L-arginine analogs such as L-NAME [10,18]. L-NAME is a L-arginine analog, which acts as a competitive inhibitor of NOS.…”

Section: Discussionmentioning

confidence: 99%

“…N-nitro L-arginine methyl ester (L-NAME) is a substance which has antiinflammatory, antioxidant and antifibrotic effects demonstrated in different studies [10][11][12]. L-NAME is a competitive inhibitor of nitric oxide synthase (NOS) and an analog of the NOS substrate L-arginine.…”

Section: Introductionmentioning

confidence: 99%

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The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis

Doğan

Erdağ

Sarıoğlu

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis

Doğan

Erdağ

Sarıoğlu

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…Here we studied the inflammatory responses in OME induced by LPS in rats, because LPS, the primary component of endotoxin that is a collection of gram-negative bacterial cell wall components with potent inflammatory properties, has repeatedly been isolated from MEEs of patients with OME [9] and was used to induce MEE in animal models [10,11].…”

Section: Discussionmentioning

confidence: 99%

Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat

Cho

Lee

Woo

et al. 2007

International Journal of Pediatric Otorhinolaryngology

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Gel chromatographic characterization of proteins in mucous and serous middle ear effusions of patients with otitis media in comparison to serum proteins

Yabe

Higo

Sugita³

et al. 2007

Eur Arch Otorhinolaryngol

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Otitis media with effusion (OME) is an inflammatory disease of the middle ear cavity that is associated with middle ear effusions (MEEs), which are frequently mucous and serous for pediatric and adult patients exhibiting low and high responsiveness to medical treatment, respectively. To assess the pathological outcomes in mucous and serous MEEs, their protein compositions were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting in comparison with those in the same patients' sera. A mucin, which is immunochemically identical with nasal mucin, was a characteristic consituent of mucous MEEs (n = 25), being present at the concentration of 59.4 mg/ml and comprising about 60% of the total proteins, but it was not detected in serous MEEs (n = 30) or sera. Serum proteins with molecular weights of less than 260 kDa were detected in serous and mucous MEEs, in which albumin was the major protein. Albumin, IgM and alpha1-acid glycoprotein, and lysozyme, IgA and IgG in MEEs were present at lower and higher concentrations than in sera, respectively. The ratios of IgA, IgG, IgM and alpha1-acid glycoprotein to albumin in mucous MEEs were 4-, 3-, 1.4- and 1.0-times higher than those in the respective pediatric sera, and those in serous MEEs were 1.7-, 1.7-, 0.6- and 0.3-times higher than those in adult sera. Also, the concentrations of lysozyme in mucous and serous MEEs were 19 and 3 microg/ml, but those in pediatric and adult sera were negligible. These results indicate that the contents of these proteins, in comparison to albumin, might be useful criteria for assessing the inflammation level in MEEs.

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Effects of Tumor Necrosis Factor Alpha Antagonist, Platelet Activating Factor Antagonist, and Nitric Oxide Synthase Inhibitor on Experimental Otitis Media with Effusion

Abstract: We conclude that sTNFRI, A-85783, and L-NAME can be proposed as alternative future treatments for otitis media with effusion. However, L-NAME may be the least effective of these agents.

Cited by 14 publications

References 18 publications

The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis

The preventive effect of N-nitro l-arginine methyl ester in experimentally induced myringosclerosis

Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat

Gel chromatographic characterization of proteins in mucous and serous middle ear effusions of patients with otitis media in comparison to serum proteins

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