Effects of two different exercise programs on chronic fatigue in lupus patients

Avaux, Marie; Hoellinger, Pauline; Nieuwland-Husson, Séverine; Fraselle, Virginie; Depresseux, Geneviève; Houssiau, Frédéric

doi:10.1080/17843286.2016.1200824

Cited by 23 publications

(7 citation statements)

References 14 publications

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“…Two RCT of exercise in SLE demonstrated clinically significant reductions in fatigue. Of note, improvement in fatigue (using the FSS) was noted even in patients with low adherence in one of these studies, raising the question of bias in the intervention group 20,21 . Low glycemic index and low-calorie diets were also shown to decrease fatigue in SLE patients when measured by the FSS.…”

Section: Resultsmentioning

confidence: 95%

Fatigue Measurements in Systemic Lupus Erythematosus

Barbacki

Petri²,

Aviña‐Zubieta³

et al. 2019

J Rheumatol

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Objective.Fatigue is a frequent, disabling issue in systemic lupus erythematosus (SLE). It is, however, difficult to quantify. The Ad Hoc Committee on SLE Response Criteria for Fatigue in 2007 recommended using the Krupp Fatigue Severity Scale (FSS). Since then, the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale has also been validated in SLE. We performed a review of instruments used to measure fatigue in adult SLE patients from 2007 onward.Methods.We searched PubMed, Medline, and Embase (January 2008–October 2017), identifying clinical trials and observational studies in adult SLE, where fatigue was a specifically measured outcome. All English and French studies were reviewed to determine fatigue measures and results.Results.Thirty-seven studies met inclusion criteria. Eight scales were used. The visual analog scale (VAS), FSS, and FACIT-Fatigue Scale were most frequent. FSS was the most often used instrument in both clinical trials and observational studies. Twenty-five of the 37 studies demonstrated a difference in fatigue that was statistically significant and clinically meaningful. Of the 12 studies that did not, 6 used FSS, 3 used VAS, 2 used the Multidimensional Assessment of Fatigue, and 1 used the Brief Fatigue Index. All 6 studies using the FACIT-Fatigue Scale detected clinically meaningful and statistically significant differences.Conclusion.VAS, FSS, and FACIT-Fatigue Scale were the most frequently used instruments in adult SLE studies from 2008 to 2017. Many studies detected clinically important changes in fatigue. Fatigue remains a key measure in both clinical trials and observational SLE studies.

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Section: Resultsmentioning

confidence: 95%

Fatigue Measurements in Systemic Lupus Erythematosus

Barbacki

Petri²,

Aviña‐Zubieta³

et al. 2019

J Rheumatol

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“…19 Therapeutic exercise also had a benefit in childhood-onset SLE patients (C-SLE). 17,26 In a cross-sectional study (n=242) by Volkmann, et al that assessed the association of physical exercise with certain cardiovascular risk markers did not find any correlation between activity or damage of SLE and exercise. 28 Prado, et al and Reis-Neto, et…”

Section: Therapeutic Exercise In Slementioning

confidence: 96%

Therapeutic Exercise in Systemic Lupus Erythematosus: Review Article

Rahmatika

Handoyo

2019

IndoJPMR

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Introduction: Systemic Lupus Erythematosus (SLE) is a prototype of an autoimmune disease characterized by the production of antibodies against cell nucleus components with a broad spectrum of clinical patterns. The SLE will cause long-term complications so that SLE patients tend to have sedentarylifestyle and decrease physical activity which reduces exercise capacity. The aim of therapeutic exercise is to improve a variety of clinical symptoms in SLE patients by alleviate the inflammatory process and modifying the disease’s natural course.Methods: All of references have searched in 2018 within the areas of rheumatology, immunology, cardiology, physical education and physiotherapy.Results: Therapeutic exercise in SLE has an anti-inflammatory effect by inhibiting the release of inflammatory mediators including TNF-α. Therapeutic exercise in the form of aerobic and resistance exercise able to improve aerobic capacity, reduced fatigue, increasing chronotropic reserve, heart raterecovery, functional performance, functional capacity, muscle strength and increase bone turn over. Therapeutic exercise was not aggravated disease activity as measured by SLE Activity Index (SLEDAI) and SLE Activity Measure (SLAM) index.Conclusion: Supervised aerobic and resistance exercise seems to help improve health, vitality and self perceived physical capacity in SLE patients.Keywords: Systemic lupus erythematosus , therapeutic exercise, SLEDAI, SLAM index

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“…60 Exercise does not worsen disease activity, 61,62 and has been associated with improvements in fatigue in SLE. 26,52–58 This has been shown via controlled trials of aerobic exercise regimens, 52,54,56 as well as a cross-sectional study that compared more physically active SLE patients to controls. 26 As fatigue remains a significant barrier to quality of life in SLE, 59 identifying strategies for improving this is critical.…”

Section: Introductionmentioning

confidence: 94%

“…Several controlled trials have evaluated 12-week aerobic exercise programs, and have shown they improved fatigue, 52,54,56 depression, 52 aerobic capacity, 64 and quality of life. 52,64 Even without targeted exercise training or regular compliance, SLE patients who engaged in more physical activity still felt improvement in fatigue compared to controls.…”

Section: Introductionmentioning

confidence: 99%

A prescription for exercise in systemic lupus erythematosus

Molina

Petri

Manno

et al. 2021

Lupus

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Patients with systemic lupus erythematosus (SLE) have increased cardiovascular risk, and fatigue is a major subjective complaint. Sedentary lifestyle has been shown to have negative health impacts in cardiovascular and rheumatic disease, though exercise has not traditionally been incorporated into routine therapy recommendations. Regular exercise in SLE may improve difficult to treat Type 2 symptoms, such as fatigue, depression, stress, and quality of life. Insufficient counseling on exercise by physicians is a notable barrier for SLE patients to engage in physical activity. Aerobic exercise regimens are more commonly studied, and have been shown to improve cardiovascular health in SLE. Exercise may improve some inflammatory markers, though does not definitively affect SLE clinical disease activity. Physical activity should be recommended to improve quality of life and cardiovascular health in patients with SLE. Developing clearer guidelines for exercise regimens in a patient-centered manner is warranted, especially given diverse phenotypes of SLE patients and varying degrees of physical limitations.

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Effects of two different exercise programs on chronic fatigue in lupus patients

Abstract: Patients included in the STG and the HTG similarly improved their fatigue, irrespectively of their level of compliance, raising the possibility that the beneficial effect on fatigue was not only exercise-related.

Cited by 23 publications

References 14 publications

Fatigue Measurements in Systemic Lupus Erythematosus

Fatigue Measurements in Systemic Lupus Erythematosus

Therapeutic Exercise in Systemic Lupus Erythematosus: Review Article

A prescription for exercise in systemic lupus erythematosus

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