Effects of two polybrominated diphenyl ethers (BDE-47, BDE-209) on the swimming behavior, population growth and reproduction of the rotifer Brachionus plicatilis

Sha, Jingjing; Wang, You; Lv, Jianxia; Hong, Wang; Chen, Hongmei; Qi, Leilei; Tang, Xuexi

doi:10.1016/j.jes.2014.07.020

Cited by 35 publications

(10 citation statements)

References 49 publications

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“…For the high dose group, the measured concentrations were 10.3% and 39.0% of the nominal 50 µg/L group at 1 dpf and 3 dpf, respectively. The results were consistent with a previous study, which showed at the nominal concentrations of 0.2 and 0.6 mg/L groups, the measured concentrations of BDE-209 were 27.0% and 13.8% nominal concentrations, respectively [25].…”

Section: Discussionsupporting

confidence: 93%

“…Another interesting result is that only the exposure of low-concentration BDE-209 induced the changes in locomotion and path angle tests at 7 dpf other than the higher concentration exposure. However, it was reported that BDE-209 at low doses was not an acute lethal toxicant and may just pose a low risk to marine rotifers [25]. Besides the potential influences of different tested species, the difference was possibly due to the fact that BDE-209 is easy to be bioaccumulated in sediment and organisms, which could cause a tenfold accumulation in zebrafish larvae in unspiked sediment after 8 days [28].…”

Section: Discussionmentioning

confidence: 97%

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The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

Zhang

Yin

et al. 2020

Environ Sci Eur

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Background: Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies of BDE-209 focused on the health effects and toxicity of thyroid disruption, oxidative stress, neurotoxicity, and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results: BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf ) larvae; however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concentration exposures. Conclusion:The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

Zhang

Yin

et al. 2020

Environ Sci Eur

View full text Add to dashboard Cite

show abstract

“…Another interesting result is that only the exposure of low concentration BDE-209 induced the significant changes in locomotion and path angle tests at 7 dpf other than the higher concentration exposure. However, it was reported that BDE-209 at environmental relevant doses was not an acute lethal toxicant and may just pose a low risk to marine rotifers [26]. Besides the potential influences of different tested species, the difference was possibly due to the fact that BDE-209 is easy to be bioaccumulated in sediment and organisms, which could cause a 10-fold accumulation in zebrafish larvae in unspiked sediment after 8 days [27].…”

Section: Discussionmentioning

confidence: 98%

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study

Zhang

Yin

et al. 2019

Preprint

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Background Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies on the health effects and toxicity of BDE-209 focused on thyroid disruption, oxidative stress, neurotoxicity and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf) larvae, however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concertation exposures.Conclusion The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.

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“…Previous studies have mainly focused on their reproductive toxicity (Sha et al, 2015), neurotoxicity (Kodavanti and Tilson, 1997), immunotoxicity (Smialowicz et al, 1989), endocrine-interference effects (Yang et al, 2008) and oncogenicity (Lucena et al, 2001;Wolff et al, 2000). However, their potential influence on element metabolism remains largely unknown.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review

Guo

Zhang

et al. 2015

Journal of Environmental Sciences

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Effects of two polybrominated diphenyl ethers (BDE-47, BDE-209) on the swimming behavior, population growth and reproduction of the rotifer Brachionus plicatilis

Cited by 35 publications

References 49 publications

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study

Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review

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