Effects of ukrain in rats with intestinal ischemia and reperfusion

Akçılar, Raziye; Akcılar, Aydın; Savran, Bircan; Ayada, Ceylan; Koçak, Cengiz; Koçak, Fatma Emel; Genç, Osman

doi:10.1016/j.jss.2014.12.040

Cited by 21 publications

(16 citation statements)

References 25 publications

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“…OSI was used as an indicator of oxidative stress in this study. OSI has been suggested that it can accurately reflect the state of oxidative status [20]. TAS demonstrates the body's total antioxidant defense.…”

Section: Tissue Enos and Inos Immunoreactivity Scoresmentioning

confidence: 99%

Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Zeren

Bayhan

Koçak

et al. 2016

Journal of Surgical Research

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Section: Tissue Enos and Inos Immunoreactivity Scoresmentioning

confidence: 99%

Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Zeren

Bayhan

Koçak

et al. 2016

Journal of Surgical Research

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“…Despite the fact that studies on mesenteric ischemia reperfusion injury treatment have been performed with many agents in the literature, no study on the effect of sesamin on mesenteric ischemia reperfusion injury has been seen [26–28]. In a study conducted by Torun et al ., it has been shown that TAS, TOS, and OSI values may not only be an indication of oxidative or antioxidative status but may also be used to evaluate treatment response [29, 30]. In our study, these parameters were measured at the tissue level in addition to the plasma values.…”

Section: Discussionmentioning

confidence: 99%

Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model

Sayhan¹,

Oguz²,

Salt³

et al. 2019

aoms

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Introduction: Mesenteric ischemia/reperfusion (I/R) injury is a serious clinical condition. There were a lot of experimental studies performed in the treatment of I/R injury. To our knowledge, this is the first experimental study with effects of sesamin on I/R injury model. We aimed to investigate the protective effect of sesamin on mesenteric I/R injury model. Material and methods: A total of 32 male Sprague-Dawley rats were divided into four groups. Control group: superior mesenteric artery (SMA) exposed without clamping. I/R group: SMA was clamped for 60 min and then reperfused for 2 h. Sesamin group (S): 30 mg/kg sesamin were given for 5 days, and SMA exposed without clamping. I/R + S group: 30 mg/kg sesamin were given for 5 days, SMA was clamped for 60 min, and then reperfused for 2 h. Plasma and tissue oxidant parameters were investigated as well as histopathological evaluation. Results: Plasma and tissue total antioxidant status (TAS) levels were significantly higher in I/R + S group compared to the rest (p < 0.005). The plasma TAS levels in I/R group was significantly low. The highest tissue TAS levels were detected in I/R + S group. The high levels of plasma and tissue TOS were found in I/R + S group. Plasma and tissue OSI levels were significantly higher in I/R group. Histopathologic evaluation showed that the mean level of intestinal tissue injury score in I/R group was 2.75 and 1.38 in I/R + S group. Conclusions: Sesamin helps to protect the intestinal tissue at the cellular level by reducing the oxidative stress and inflammation at both the plasma and tissue levels in the experimental I/R model.

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“…Owing to the relative failure of the clinical treatment of reperfusion injury and in light of previous studies, the importance of targeting reperfusion injury in cases of intestinal ischemic injury has been brought into question. Recent studies demonstrated that ukrain, an alkaloid thiophosphoric acid derivative of greater celandine (Chelidonium majus, a member of the Papaveraceae family), helps to prevent intestinal tissue breakdown during intestinal IR injury and that this effect can be achieved by antioxidant activities [27]. Gu et al [28] suggested that IR-induced intestinal tight junction dysfunction can be improved by berberine, thereby demonstrating the therapeutic potential of berberine for intestinal IR.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of berberine on intestinal ischemia and reperfusion injury in rats

Chen

2017

ARCH BIOL SCI BELGRA

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This study aims to investigate the potential protective effects of berberine on ischemia and reperfusion (IR) injury in rats. Thirty male rats were randomly divided into three experimental groups as follows: the sham group, the IR group and the berberine+IR group. Intestinal ischemia-reperfusion was performed by occlusion of the superior mesenteric artery for 30 min, followed by 2-h reperfusion. The berberine+IR group of rats were administered 200 mg/kg of berberine once a day for 7 days before laparotomy. Compared with the IR group, rats pretreated with berberine prior to IR had significantly reduced intestinal ischemia/reperfusion injury and a significant reduction in Chiu's score (p<0.05). The level of malondialdehyde and myeloperoxidase in the berberine+IR group was significantly decreased compared with the IR group (p<0.001). Superoxide dismutase activity in the berberine+IR group was significantly higher than in the IR group (p<0.001). Compared with the IR group, diamine oxidase was markedly decreased in the berberine+IR group (p<0.01). The level of secretory immunoglobulin A in the berberine+IR group was significantly increased when compared to the IR group (p<0.001). Our results suggest that berberine can protect from intestinal IR injury and that it can be beneficial in treating conditions associated with intestinal IR injury.

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Effects of ukrain in rats with intestinal ischemia and reperfusion

Cited by 21 publications

References 25 publications

Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model

Protective effects of berberine on intestinal ischemia and reperfusion injury in rats

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