Effects of ultrasound-assisted extraction on antioxidant activity and bidirectional immunomodulatory activity of Flammulina velutipes polysaccharide

Ovotransferrin exerts bidirectional immunomodulatory activities via TLR4‐mediated signal transduction pathways in RAW264.7 cells

“…The toll-like receptor family (TLRs) is the most widely studied PRR. Over the past few years, it has been bound to a variety of ligands including sugars (Chen et al, 2019), proteins (Ren et al, 2010), and lipids (Diao et al, 2019) in LPS-stimulated RAW264.7 and have anti-inflammatory effect (Guo et al, 2019). Similar with study of Ganoderma protein receptor (Li, Chang, et al, 2019), the data showed that OVT may combine with TLR4 to exert immune enhancement functions, but it did not exert anti-inflammatory function by inhibiting the expression of these two genes according the current observations (Lee et al, 2019).…”

“…The toll‐like receptor family (TLRs) is the most widely studied PRR. Over the past few years, it has been bound to a variety of ligands including sugars (Chen et al., 2019 ), proteins (Ren et al., 2010 ), and lipids (Diao et al., 2019 ). TLR4 is associated with LPS‐induced inflammation and is widely distributed in a variety of cells such as macrophages, monocytes, neutrophils and dendritic cells.…”

Extraction, Structural Characterisation, and Immunomodulatory Properties of Edible Amanita hemibapha subspecies javanica (Corner and Bas) Mucilage Polysaccharide as a Potential of Functional Food

“…Many studies have reported that polysaccharides from mushrooms have a variety of types of bioactivities such as immunomodulatory, antioxidant, anticancer, antibacterial, and anti-inflammatory bioactivities, as shown in Table 1 . This table shows extraction methods, and the bioactivity of polysaccharides from mushrooms [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. The immunostimulatory activity is due to the great potential of polysaccharides such as lentinan, schizophyllan, and β-glucan to modulate the immune system [ 25 ].…”

In vitro and in vivo functional characterization of an immune activation Flammulina velutipes polysaccharide based on gut microbiota regulation

“…The activation and regulation effect on the immune system arise from various mushroom polysaccharides received extensive attentions and research studies (Meng et al, 2016). Like most nature products, mushroom polysaccharides have a two-way regulatory effect on the host immune system, either enhance the immunity of normal organisms or improve the inflammation symptoms of inflammatory organisms (Chen et al, 2019;Taofiq et al, 2016). The immune boosting activity of mushroom polysaccharides appeared to be mediated through the macrophage stimulation (Zong et al, 2012).…”