Effects of Ultraviolet Photofunctionalization on Bone Augmentation and Integration Capabilities of Titanium Mesh and Implants

Hirota, Makoto; Ikeda, Takayuki; Tabuchi, Masako; Ozawa, Tomomichi; Tohnai, Iwai; Ogawa, Takahiro

doi:10.11607/jomi.4891

Cited by 22 publications

(32 citation statements)

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“…Studies have demonstrated that surface hydrophilicity and bioactive ion chemistry are potent factors that modulate the speed and quality of implant osseointegration. [1][2][3][4][5][6] It has been reported that titanium (Ti) bone implants that have been surface modified with bioactive ions and have an enhanced hydrophilicity promote early bone formation by enhancing adhesion and osteoblastic differentiation of osteogenic cells on the implant surface. [1][2][3][4] Simple wet chemical treatment using phosphoric acid provides the Ti implants with these two important surface properties (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 The improved surface hydrophilicity further increased the bone healing capacity of microstructured Ti implants of the same surface ion composition. [5][6][7][8][9][10] Elucidation of the biological mechanisms underlying the osteogenic capacity of a modified Ti surface during the early stages of bone healing is essential for an improved surface design of Ti implants. Enhancement of the early cellular events, including adhesion and spreading on the implant surface, is crucial to achieving favorable osteogenesis functions of bone-forming cells, and ultimately the bone regeneration that occurs around the implants.…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic differentiation of mesenchymal stem cells modulated by a chemically modified super-hydrophilic titanium implant surface

Kwon

Park

2018

J Biomater Appl

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This study investigated the osteogenic functionality of multipotent mesenchymal stem cells (MSCs) modulated by a chemically modified super-hydrophilic titanium (Ti) bone implant surface to elucidate the biological mechanism underlying the bone healing capacity of this modified Ti surface. A microstructured Ti surface incorporating bioactive ions (in this study, phosphate (P) ions) was prepared by wet chemical treatment. The results showed that the hydrothermally obtained crystalline P-incorporated Ti surface (P surface) displayed long-term super-hydrophilicity (water contact angles <5°) during a 36-week observation period. The hydrophilic P surface enhanced early cellular functions and osteogenic differentiation of multipotent MSCs derived from mouse bone marrow and human adipose tissue. The expression of critical integrins affecting subsequent osteoblast function and osteoblast phenotype genes was notably upregulated in multipotent MSCs grown on the P surface compared with the commercially available grit-blasted microrough clinical oral implant surface. The P surface supported better cell spreading, focal adhesion and ALP activity of MSCs. These results indicate that a super-hydrophilic P-incorporated Ti surface accelerates implant bone healing by enhancing the early osteogenesis functions of multipotent MSCs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteogenic differentiation of mesenchymal stem cells modulated by a chemically modified super-hydrophilic titanium implant surface

Kwon

Park

2018

J Biomater Appl

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“…Successful implant osseointegration has also been observed for photofunctionalized dental implants placed in gap-healing models and compromised bone conditions (Hirota et al, 2014(Hirota et al, , 2017Hirota, Tanaka, et al, 2016;Kim et al, 2016;Lee et al, 2018;Petzold, Rubert, Lyngstadaas, Ellingsen, & Monjo, 2011;. The bone volume around acid-etched titanium cylindrical rods after photofunctionalization was around three times greater compared to that in control implants, according to a previous study in a gap-healing model in rats after 2 weeks of healing .…”

Section: F I G U R Ementioning

confidence: 54%

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Dini

Nagay

Magno

et al. 2020

Clinical Oral Implants Res

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Objectives To determine whether photofunctionalization influences dental implant osseointegration. Material and methods Data on osseointegration rates were extracted from 8 databases, based on bone‐to‐implant contact (BIC) and pushout tests. Internal validity was accessed through the SYRCLE risk of bias tool for animal experimental studies. Meta‐analyses were performed for investigation of the influence of photofunctionalization on implant osseointegration, with a random effect and a confidence interval of 95%. The certainty of evidence was accessed through the GRADE approach. Results Thirty‐four records were identified, and 10 were included in the meta‐analysis. Photofunctionalized implants showed higher mean values for BIC in rabbits (MD 6.92 [1.01, 12.82], p = .02), dogs (MD 23.70 [10.23, 37.16], p = .001), rats (MD 20.93 [12.91, 28.95], p < .0001), and in the pooled BIC analyses (MD 14.23 [7.80, 20.66], p < .0001) compared to those in control implants in the overall assay. Conversely, at late healing periods, the pooled BIC meta‐analyses showed no statistically significant differences (p > .05) for photofunctionalized and control implants at 12 weeks of follow‐up. For pushout analysis, photofunctionalized implants presented greater bone strength integration (MD 19.92 [13.88, 25.96], p < .0001) compared to that of control implants. The heterogeneity between studies ranged from “not important” to “moderate” for rabbits I2 = 24%, dogs I2 = 0%, rats I2 = 0%, and pooled BIC (I2 = 49%), while considerable heterogeneity was observed for pushouts (I2 = 90%). Conclusion Photofunctionalization improves osseointegration in the initial healing period of implants, as summarized from available data from rabbit, dog, and rat in vivo models.

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“…Nevertheless, superhydrophilic surfaces can increase adsorption of protein, osteoblast migration, and proliferation and promote osteoblastic differentiation . In vitro and in vivo studies have proved the rapid and complete establishment of bone‐titanium integration in superhydrophilic surfaces, regardless surface topography . This technology has already been applied in dental implant therapies with a new chemically modified hydrophilic sand‐blasted large‐grit acid‐etched surface (SLActive), for example .…”

Section: Current Biomaterial‐based Solutions To Prevent Peri‐implantitismentioning

confidence: 99%

Biomaterial‐based possibilities for managing peri‐implantitis

Ávila

Oirschot

Beucken

2019

J of Periodontal Research

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Peri‐implantitis is an inflammatory disease of hard and soft tissues around osseointegrated implants, followed by a progressive damage of alveolar bone. Oral microorganisms can adhere to all types of surfaces by the production of multiple adhesive factors. Inherent properties of materials will influence not only the number of microorganisms, but also their profile and adhesion force onto the material surface. In this perspective, strategies to reduce the adhesion of pathogenic microorganisms on dental implants and their components should be investigated in modern rehabilitation concepts in implant dentistry. To date, several metallic nanoparticle films have been developed to reduce the growth of pathogenic bacteria. However, the main drawback in these approaches is the potential toxicity and accumulative effect of the metals over time. In view of biological issues and in attempt to prevent and/or treat peri‐implantitis, biomaterials as carriers of antimicrobial substances have attracted special attention for application as coatings on dental implant devices. This review will focus on biomaterial‐based possibilities to prevent and/or treat peri‐implantitis by describing concepts and dental implant components suitable for engagement in preventing and treating this disease. Additionally, we raise important criteria referring to the geometric parameters of dental implants and their components, which can directly affect peri‐implant tissue conditions. Finally, we overview currently available biomaterial systems that can be used in the field of oral implantology.

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Effects of Ultraviolet Photofunctionalization on Bone Augmentation and Integration Capabilities of Titanium Mesh and Implants

Cited by 22 publications

References 0 publications

Osteogenic differentiation of mesenchymal stem cells modulated by a chemically modified super-hydrophilic titanium implant surface

Osteogenic differentiation of mesenchymal stem cells modulated by a chemically modified super-hydrophilic titanium implant surface

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Biomaterial‐based possibilities for managing peri‐implantitis

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