Effects of Ultraviolet Radiation on Serum 25-Hydroxyvitamin D Concentrations in Captive Chinchillas (Chinchilla laniger)

Rivas, Anne E.; Mitchell, Mark A.; Flower, Jennifer E.; Welle, Kenneth R.; Whittington, Julia K.

doi:10.1053/j.jepm.2014.05.012

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…This ability to sustain substantially higher levels of 25-OHD 3 from UVB exposure compared to animals provided vitamin D in diet alone reinforces that these animals evolved with this mechanism to procure and maintain adequate levels of vitamin D. Guinea pigs are naturally a high altitude, low latitude species, with ample access to sunlight and natural UVB radiation in their home range. A recent pilot study also demonstrated that chinchillas ( Chinchilla lanigera ), which are also native to the Andes Mountains, have the ability to produce 25-OHD 3 through photobiochemical synthesis following exposure to artificial UVB lights [14] . Other animals native to similar environments, such as llamas ( Lama glama ) and alpacas ( Vicugna pacos ), have been shown to develop significant disease secondary to a seasonally dependent hypovitaminosis D [20] .…”

Section: Discussionmentioning

confidence: 99%

“…The sample size selected for this study (n = 12; 6 per group) was based on the following assumptions: an expected mean difference in serum 25-OHD 3 concentrations of 35 nmol/L between treatment and control groups with a SD of 20 nmol/L [13] , [14] , an alpha of 0.05, and a power of 0.8 (MedCalc 11.3.2.0). Distribution of the data was evaluated by use of the Shapiro-Wilk test.…”

Section: Methodsmentioning

confidence: 99%

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Evaluating the Clinical and Physiological Effects of Long Term Ultraviolet B Radiation on Guinea Pigs (Cavia porcellus)

et al. 2014

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Vitamin D is an important hormone in vertebrates. Most animals acquire this hormone through their diet, secondary to exposure to ultraviolet B (UVB) radiation, or a combination thereof. The objectives for this research were to evaluate the clinical and physiologic effects of artificial UVB light supplementation on guinea pigs (Cavia porcellus) and to evaluate the long-term safety of artificial UVB light supplementation over the course of six months. Twelve juvenile acromelanic Hartley guinea pigs were randomly assigned to one of two treatment groups: Group A was exposed to 12 hours of artificial UVB radiation daily and Group B received only ambient fluorescent light for 12 hours daily. Animals in both groups were offered the same diet and housed under the same conditions. Blood samples were collected every three weeks to measure blood chemistry values, parathyroid hormone, ionized calcium, and serum 25-hydroxyvitamin D3 (25-OHD3) levels. Serial ophthalmologic examinations, computed tomography scans, and dual energy x-ray absorptiometry scans were performed during the course of the study. At the end of the study the animals were euthanized and necropsied. Mean ± SD serum 25-OHD3 concentrations differed significantly in the guinea pigs (p<0.0001) between the UVB supplementation group (101.49±21.81 nmol/L) and the control group (36.33±24.42 nmol/L). An increased corneal thickness in both eyes was also found in the UVB supplementation compared to the control group (right eye [OD]: p<0.0001; left eye [OS]: p<0.0001). There were no apparent negative clinical or pathologic side effects noted between the groups. This study found that exposing guinea pigs to UVB radiation long term significantly increased their circulating serum 25-OHD3 levels, and that this increase was sustainable over time. Providing guinea pigs exposure to UVB may be an important husbandry consideration that is not currently recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Evaluating the Clinical and Physiological Effects of Long Term Ultraviolet B Radiation on Guinea Pigs (Cavia porcellus)

et al. 2014

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“…Emerson et al [ 3 ] did not report any adverse effects in domestic rabbits following a 12 h/day 14-day exposure to artificial UVB; however, screening for negative findings was limited to a physical examination. A similar study was performed on chinchillas ( Chinchilla lanigera ) exposed to 12 h/day of artificial UVB irradiation for 16 days with no reported adverse effects [ 11 ]. A longer-term study evaluating the same artificial UVB exposure in domestic rabbits screened the animals for adverse side effects using ophthalmic examinations performed by a board-certified veterinary ophthalmologist and full necropsies with histopathology and found no abnormalities suggesting any pathology associated with the 12 h/day exposure for 6 months [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Short-Duration Artificial Ultraviolet B Exposure on 25-Hydroxyvitamin D3 Concentrations in Domestic Rabbits (Oryctolagus cuniculus)

Molitor

Rockwell

Gould

et al. 2023

Animals

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Vitamin D is an important hormone that can be acquired through diet, exposure to ultraviolet B (UVB) radiation, or a combination of these methods. In domestic rabbits (Oryctolagus cuniculus), both methods appear viable, but there is limited research evaluating the effects of UVB on this species. Previous studies found that 12 h of artificial UVB radiation significantly increased 25-hydroxyvitamin D3 (25-OHD3) concentrations over time. While these findings suggest UVB can be beneficial in rabbits, this form of radiation can also be detrimental to vertebrates. The purpose of this study was to determine if shorter-duration UVB could elicit a similar physiological response in rabbits while minimizing potential negative effects. Six rabbits were used for this pilot study. The baseline serum 25-OHD3 was measured for each rabbit and following 14 days of 6 h/day exposure to artificial UVB, a second 25-OHD3 sample was collected. There was a significant increase (p = 0.001) in serum 25-OHD3 over time (Baseline: 27.7 ± 8.1 nmol/L; Day 14: 79.8 ± 9 nmol/L). This study affirmed that 6 h of UVB produced 25-OHD3 concentrations similar to those found in rabbits exposed to 12 h of UVB. Future studies should continue to determine how the duration of UVB exposure affects 25-OHD3 concentrations.

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Clinical Pathology

Monteiro¹,

Brandão

2021

Exotic Animal Emergency and Critical Care Medicine

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Effects of Ultraviolet Radiation on Serum 25-Hydroxyvitamin D Concentrations in Captive Chinchillas (Chinchilla laniger)

Cited by 12 publications

References 24 publications

Evaluating the Clinical and Physiological Effects of Long Term Ultraviolet B Radiation on Guinea Pigs (Cavia porcellus)

Evaluating the Clinical and Physiological Effects of Long Term Ultraviolet B Radiation on Guinea Pigs (Cavia porcellus)

Effects of Short-Duration Artificial Ultraviolet B Exposure on 25-Hydroxyvitamin D3 Concentrations in Domestic Rabbits (Oryctolagus cuniculus)

Clinical Pathology

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