Effects of Unilateral Clefts on Brain Structure

Plas, Ellen van der; Conrad, Amy L.; Canady, John W.; Richman, Lynn C.; Nopoulos, Peg

doi:10.1001/archpediatrics.2010.123

Cited by 23 publications

(23 citation statements)

References 35 publications

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“…The finding here, however, suggests that there may be a closer connection between patterning of the brain and a right‐sided cleft that increases the odds of having learning problems. These findings are particularly interesting when considered in light of results from an earlier imaging study showing reduced white matter in children with right‐sided clefts relative to those with left‐sided clefts and unaffected controls (van der Plas, Conrad, Canady, Richman, & Nopoulos, ). Academic differences related specifically to exposure to anesthesia, speech disorders related to cleft palate, or the psychosocial aspect of having a cleft would not be likely to show differences based on cleft laterality.…”

Section: Discussionmentioning

confidence: 78%

Associations between laterality of orofacial clefts and medical and academic outcomes

Gallagher

Siebold

Collett

et al. 2017

American J of Med Genetics Pt A

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Patients with oral clefts have an increased risk of other malformations, syndromes, and lower academic performance in school. Few studies have investigated if laterality of clefts is associated with medical and academic outcomes. Oral clefts have nonrandom laterality, with left-sided clefts occurring approximately twice as often as right-sided clefts. Using a retrospective study design, we examined potential associations of cleft attributes and outcomes in patients with cleft lip with or without cleft palate (CL/P) born in 2003-2010 who were treated at the Seattle Children's Craniofacial Center. The following variables were extracted from medical records: cleft type, medical history, maternal hyperglycemia, other malformations, and the need for academic support at school. We used logistic regression to examine risk of associations with outcomes of interest. Relative to patients with left-sided clefts, patients with bilateral CL/P were more likely to have a syndrome. Patients with nonsyndromic right-sided CL/P had a higher risk (OR and 95%CI: 3.5, 1.3-9.5, and 5.5, 1.9-16.0, respectively) of having other malformations and requiring academic support at school, when compared to patients with left-sided CL/P. Understanding the etiology of oral clefts is complicated, in part because both genetic and environmental factors contribute to the risk of developing a cleft. However, the different outcomes associated with cleft laterality suggest that right-sided clefts may have a distinct etiology. Using laterality to study cleft subgroups may advance our understanding of the etiology of this common birth defect.

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Section: Discussionmentioning

confidence: 78%

Associations between laterality of orofacial clefts and medical and academic outcomes

Gallagher

Siebold

Collett

et al. 2017

American J of Med Genetics Pt A

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“…Of note, growth problems in children with clefts are not confined to height, as delays are reported for the musculoskeletal system (4,13), dental development (35), and brain development (12,36–38). Birth defects often affect a combination of organs, and a triad of defects in the craniofacial region, the central nervous system, and the musculoskeletal system is particularly common (4,39).…”

Section: Resultsmentioning

confidence: 99%

Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

et al. 2012

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INTRODUCTION Individuals with isolated cleft lip and/or palate (ICLP) are often reported to be of shorter stature relative to peers, and the objective of this study was to explore the role of the pituitary in relationship to growth. METHODS Fifty-five males and 32 females with ICLP were compared to 121 healthy males and 158 healthy females with respect to height and BMI. Magnetic resonance imaging (MRI) scans were obtained from all ICLP participants and 47% of healthy group participants. RESULTS Males with ICLP were shorter than healthy males and had lower BMI. However, the trajectories for height and BMI did not differ between groups. Analyses in a separate sample of adult males suggested that height normalizes in males with ICLP in their early 30s. There were no differences in mean pituitary volume and pituitary trajectories between male groups. Females with ICLP were shorter than healthy females and also had slower growth rates. They did not differ in mean BMI or BMI trajectories. Furthermore, there were no differences in mean pituitary volume, or in pituitary trajectories. DISCUSSION Our findings suggest that there are no gross morphological differences in pituitary volume in individuals with ICLP, although more subtle differences may exist.

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“…Brain anomalies were reported in 3 of 13 calves with palatal clefts . These data suggest that, especially in dogs with congenital orofacial clefts, ventricular anomalies should be carefully investigated, because orofacial clefts could be considered a marker for abnormal brain development in view of intimately related prenatal development of the brain and the face . In people, central nervous system malformation is reported as one of the most common malformations in patients with oral clefts .…”

Section: Discussionmentioning

confidence: 86%

“…Approximately two thirds or more of facial clefts in people are isolated anomalies (non‐syndromic clefts); however, >350 developmental syndromes associated with CL and CP have been identified . Much less is known about syndromic cleft palate in dogs, but similar to human medicine, other craniomaxillofacial (and extracranial) abnormalities associated with oral clefts have been reported in dogs . Co‐existing anomalies and diseases as well as the extent of the clefts, which may vary greatly, can markedly affect the prognosis and/or treatment plans …”

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confidence: 99%

Craniomaxillofacial Abnormalities in Dogs With Congenital Palatal Defects: Computed Tomographic Findings

et al. 2014

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Effects of Unilateral Clefts on Brain Structure

Cited by 23 publications

References 35 publications

Associations between laterality of orofacial clefts and medical and academic outcomes

Associations between laterality of orofacial clefts and medical and academic outcomes

Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

Craniomaxillofacial Abnormalities in Dogs With Congenital Palatal Defects: Computed Tomographic Findings

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