Effects of urethane and ketamine on substance P- and excitatory amino acid-induced behavior in mice

Daló, Nelson L.; Larson, Alice A.

doi:10.1016/0014-2999(90)90679-z

Cited by 24 publications

(6 citation statements)

References 9 publications

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“…Cells responsible for centrifugal input from OC or AON would not be included in regular OB slices and are likely to be affected by anesthetics (urethane is thought to affect NMDA receptors (Dalo and Larson, 1990)) explaining why ultrafast synchronization is not found in these preparations. Interestingly, if excitatory centrifugal input is involved then these fibers would have to make excitatory synapses on MCs.…”

Section: Discussionmentioning

confidence: 99%

Associative Cortex Features in the First Olfactory Brain Relay Station

Doucette

Gire

Whitesell

et al. 2011

Neuron

158

174

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Summary Synchronized firing of mitral cells (MCs) in the olfactory bulb (OB) has been hypothesized to help bind information together in olfactory cortex (OC). In this first survey of synchronized firing by suspected MCs in awake-behaving vertebrates we find the surprising result that synchronized firing conveys information on odor value (is it rewarded?) rather than odor identity (what is the odor?). We observed that as mice learned to discriminate between odors synchronous firing responses to the rewarded and unrewarded odors became divergent. Further, adrenergic blockage decreases the magnitude of odor divergence of synchronous trains suggesting that MCs contribute to decision-making through adrenergic-modulated synchronized firing. Thus, in the olfactory system information on stimulus reward is found in MCs one synapse away from the sensory neuron.

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Section: Discussionmentioning

confidence: 99%

Associative Cortex Features in the First Olfactory Brain Relay Station

Doucette

Gire

Whitesell

et al. 2011

Neuron

158

174

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show abstract

“…urethane can be a useful anesthetic for experiments on the central organization of lower urinary tract function in rats. However, it should be cautioned that urethane interferes with the actions of glutamate and its analogs [Daló and Larsson, 1990;Evans and Smith, 1982]. In particular, there is a significant interaction between urethane and NMDA receptor-dependent glutamatergic neurotransmission in the micturition pathway [Yoshiyama et al, 1994].…”

Section: Discussionmentioning

confidence: 99%

Effect of anesthetics on reflex micturition in the chronic cannula-implanted rat

Matsuura

Downie

2000

Neurourol. Urodynam.

142

123

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“…Several studies have already reported that the use of anaesthesia constitutes a very serious experimental bias (Crawford, 1970;Nicoll and Madison, 1982;Heym et al, 1984;Kelland et al, 1989;Dalo and Larson, 1990;Mereu et al, 1994Mereu et al, , 1995Pirot et al, 1995;Melis et al, 1998), in great part due to anaesthetic actions on many channel coupledreceptors, as has been recently reviewed (Mihic and Harris, 1997). All these data emphasize that care must be taken in the interpretation of results obtained in anaesthetized animals to infer a normal function.…”

mentioning

confidence: 99%