In this paper, we present a set of nine user interface design patterns for in-vehicle infotainment systems centered on the content, interaction mode, style, shortcuts, and notifications of the system, which are built based on both theoretical support and an empirical pattern finding process. This empirical process consists in an exploratory test made with 10 users from an age range from 18 to 29 and with a minimum of 2 years of driving experience, who were asked to perform a set of 13 secondary tasks in the vehicle to identify recurrent problems, behavioral patterns, and best practices. The output of this exploratory test was used as the main data source for the design patterns consolidation. It is worth mentioning that the proposal of these patterns arose as an initiative to begin to consider factors that can affect the driver’s experience in the Latin American context. The set of design patterns has been validated via a content validation (as an exploratory study) by a panel of Latin American experts in the area of HCI and UX through the development of a prototype using the patterns as a tool for the redesign proposal of the infotainment systems tested during the empirical finding process.