Effects of Valsartan and Telmisartan on the LungTissue Histology in Sensitized Rats

Abstract

The renin-angiotensin system (RAS)was potentially implicated in the pathogenesis of pulmonary disorders through its involvement in inducing pro-inflammatory mediators in the lung tissues. The present study evaluates the effects of the angiotensin receptor blockers (ARBs), telmisartan and valsartan, on the histological changes of lung tissues in sensitized rats. Twenty-fourWister female rats were randomly divided into four groups: A, negative control; B, valsartan-treated group; C, telmisartan-treated group and D, positive control. The rats in the groups B-D were sensitized and challenged with ovalbumin (OVA). Group A rats were sensitized and challenged with normal saline. Rats from groups B and C were treated with either valsartan or telmisartan (5mg/kg/day), respectively. The effects of administered ARBs on lung tissue structures were histologically evaluated. Treatment with telmisartan significantly attenuates the inflammatory and the hyper-proliferative changes in lung tissue after OVA-challenge, while valsartan did not show such effect. In conclusion, telmisartan demonstrates anti-inflammatory and anti-proliferative activities in sensitized rats, while valsartan lacks these effects.

Intraperitoneal Administration of Telmisartan Prevents Postsurgical Adhesion Band Formation

“…Investigating the affinity of angiotensin II receptor type I antagonists showed a high interaction between Telmisartan and this receptor, compared to valsartan and Losartan (59), which may be attributed to the more potent of Telmisartan in decreasing adhesion bands in the rat model. Moreover, in another study administration of Telmisartan notably diminished the inflammatory responses in pulmonary tissue, while no such effects were shown for Valsartan treatment in the same doses (60). Moreover, enrichment of the apoptosis pathway in the gene expression data raised the hypothesis that Telmisartan may balance the proliferation and apoptosis of macrophages and fibroblasts that are accumulated at the site of surgery.…”

An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

“…In this study, the rat model sensitization was induced by OVA antigen and the aluminum hydroxide as an adjuvant, together they stimulated the rat's adaptive immune response (Casaro et al, 2019). The use of OVA has been employed in previous studies to induce respiratory inflammation in rats (Algaem et al, 2013, Hsu et al, 2012.…”

“…The rats inhaled this aerosol for 30 minutes each day as part of the challenging process. On day 15, the rats were killed by an IP injection of (800 mg/kg) of sodium phenobarbital and sacrificed for further analysis and examination (Ahmed et al, 2021, Algaem et al, 2013, Alabdali and Ibrahim, 2023. In groups receiving prednisolone and famotidine, the drug doses were given 60 minutes before exposing the rats to airway sensitization with OVA.…”

The Role of Rosmarinic Acid in the Protection Against Inflammatory Factors in Rats Model With Monocrotaline-Induced Pulmonary Hypertension: Investigating the Signaling Pathway of NFκB, OPG, Runx2, and P-Selectin in Heart

“…The specimens were perfused with paraffin, cut into 4-µm sections, stained with H&E, and then examined under a light microscope to determine pathological changes in lung tissue. 31…”