Effects of Variants in &amp;lt;i&amp;gt;Proopiomelanocortin and Neuropeptide Y&amp;lt;/i&amp;gt; Genes on Growth, Carcass, and Meat Quality Traits in Rabbits

Li, Wenchao; Chen, Shiyi; Jia, Xianbo; Wang, Jie; Lai, Songjia

doi:10.5713/ajas.2013.13807

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Fontanesi et al (2011Fontanesi et al ( , 2012a, Fontanesi et al (2012bFontanesi et al ( , 2014 et Fontanesi et al (2016) ont étudié le caractère de croissance le plus couramment enregistré et sélectionné dans les populations commerciales de production de viande, le poids à 70 jours. D'autres auteurs (Peng et al, 2013 ;Zhang et al, 2013aZhang et al, , 2013cLiu et al, 2014 ;Wang et al, 2015) ont étudié des caractères de croissance, de carcasse et de qualité de viande mesurés à des âges différents. Le gène de la myostatine (MSTN) a fait l'objet de nombreuses études chez le lapin en raison des effets bien connus des mutations de ce gène sur le développement du tissu musculaire.…”

Section: Caractères De Croissance Et De Carcasseunclassified

La génomique du lapin : avancées, applications et perspectives

Garreau

Gunia

2018

INRA Prod. Anim.

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L’évolution récente des technologies de séquençage et l’apport de la génomique a révolutionné nos connaissances sur les génomes et leurs polymorphismes, et permis d’élaborer des outils de génotypage qui accélèrent l’identification de polymorphismes causaux et contribuent à améliorer significativement le progrès génétique réalisé chez certaines espèces d’élevage, en particulier les bovins laitiers. Le séquençage complet du génome du lapin réalisé par le « Broad Institute » (Boston, USA), avec l’appui d’un consortium international auquel a contribué l’INRA, a été publié en 2014. Les résultats obtenus ont apporté un éclairage nouveau sur l’évolution et la domestication du lapin. En 2016, dans le cadre d’un projet Européen (COST Action TD1101 « A Collaborative European Network on Rabbit Genome Biology – RGB-Net »), une puce de génotypage avec 200000 SNP (« Single-Nucleotide Polymorphism ») a été développée, permettant de renouveler les approches de génétique chez le lapin. L’objet de cette synthèse est de faire le point sur les connaissances relatives au génome du lapin et d’établir un inventaire des gènes ou régions génomiques liés à certaines fonctions ou caractères d’intérêt dans cette espèce. Nous décrivons ici le principe des outils (cartes génétiques, puces SNP, séquençage) et des méthodes (détection de QTL, approche gènes candidats, identification de mutations causales) qui ont déjà été appliqués chez le lapin. Nous illustrons les perspectives d’utilisation des outils maintenant disponibles pour la sélection avec deux projets de recherche portant sur la résistance aux maladies et l’efficacité alimentaire. Une réflexion prospective sur la sélection génomique est également proposée.

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Section: Caractères De Croissance Et De Carcasseunclassified

La génomique du lapin : avancées, applications et perspectives

Garreau

Gunia

2018

INRA Prod. Anim.

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“…The central melanocortinergic pathway plays an important role in the control of mammalian energy homeostasis, and has recently been highlighted by genetic studies in obese humans and mice by Huszar et al, (1997). Single-nucleotide polymorphism (SNP) is a potent method for detecting polymorphisms caused by point mutations that give rise to different alleles containing alternative bases at a given nucleotide position within locus (Liu et al, 2014). Therefore, the present study was carried out to evaluate the association between (MC4R) gene polymorphism and live body weight of rabbits.…”

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Melanocortin 4 receptor (Mc4r) gene polymorphism and its association with body weights of some breeds of rabbit

Osaiyuwu

Bolaji

Adeyinka

et al. 2020

NJAP

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In livestock production, traditional methods of selection have always been the way to go. However, with the advent of genomics techniques, methods such as PCR-RFLP is been employed to identify single nucleotide polymorphism of likely candidate genes useful for livestock selection and improvement. Therefore, the aim of this study was to investigate the association of Melanocortin 4 Receptor (MC4R) gene polymorphism with the body weight ofrabbits. Seventy-four rabbits were used for this study consisting of six breeds; 26 Chinchilla, 3 Californian, 11 Dutch, 4 English Spot, 10 New Zealand White and 20 Fauve de Bourgogne (FDB) breeds. Blood samples were collected from the animals with needle and syringe and transferred unto FTA cards and stored away from light. Body weight measurements on the animals were recorded from 2 weeks to 20 weeks. PCR-RFLP analysis produced threegenotypes AA, AG, GG with genotype frequency of 0.14, 0.69 and 0.18 respectively. Allele frequency 0.48 and 0.52 for allele A and G respectively was obtained. Chi-square test showed that the population was not in Hardy-Weinberg equilibrium. Association analysis between the MC4R “c.101G>A” SNP and body weight of rabbit was tested using GLM procedure of SAS programme. Genotype GG had higher body weight (p<0.05) at 12, 16 and 20 weeks inthe Dutch rabbits while genotype AA recorded a higher (p<0.05) body weight value at 12 weeks in New Zealand White rabbits. More so, female Dutch rabbits had higher (p<0.05) mean weight than the males at 12, 16 and 20 weeks of age. Male New Zealand White breeds recorded higher (p<0.05) mean weight than the female animals. The result of the study showed that MC4R “c.101G>A” SNP was not associated with the body weight in the studied rabbit population, although, genotype AA had higher mean weight values at 12, 16 and 20 weeks of age than genotypes AG and GG.

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Association of single nucleotide polymorphisms in Neuropeptide Y (NPY) and Phosphoglycerate Mutase 2 (PGAM2) genes with growth traits in rabbits

Helal,

Ahmed,

Ragab

et al. 2024

Trop Anim Health Prod

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Genetic improvement of local rabbit breeds using modern approaches such as marker-assisted selection requires accurate and precise information about marker‒trait associations in animals with different genetic backgrounds. Therefore, this study was designed to estimate the association between two mutations located in the Neuropeptide Y (NPY, g.1778G > C) and Phosphoglycerate Mutase 2 (PGAM2, c.195 C > T) genes in New Zealand White (NZW), Baladi (BR), and V-line rabbits. The first mutation was genotyped using high-resolution melting, and the second mutation was genotyped using the PCR-RFLP method. The results revealed significant associations between the NPY mutation and body weight at 10 (V-line) and 12 weeks of age (NZW, BR, and V-line), body weight gain (BWG) from 10 to 12 weeks of age (BR), BWG from 6 to 12 weeks of age (NZW, BR, and V-line), average daily gain (NZW, BR, and V-line, and BR), growth rate (GR) from 8 to10 weeks (V-line), 10 to 12 weeks (BR), and GR from 6 to 12 weeks of age (BR, and V-line). The PGAM2 mutation was associated with body weight at 10 (V-line) and 12 (NZW, and V-line) weeks of age, with significant positive additive effects at 12 weeks of age in all breeds, and was associated with BWG from 8 to 10 and 10 to 12 in BR, and BWG from 6 to 12 weeks of age (NZW, and BR), and average daily gain (NZW, and BR), and was associated with GR form 8 to 10 weeks (BR), from10 to 12 weeks (BR, and V-line) and from 6 to 12 weeks (BR). The results highlighted the importance of the two mutations in growth development, and the possibility of considering them as candidate genes for late growth in rabbits.

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Effects of Variants in <i>Proopiomelanocortin and Neuropeptide Y</i> Genes on Growth, Carcass, and Meat Quality Traits in Rabbits

Cited by 6 publications

References 42 publications

La génomique du lapin : avancées, applications et perspectives

La génomique du lapin : avancées, applications et perspectives

Melanocortin 4 receptor (Mc4r) gene polymorphism and its association with body weights of some breeds of rabbit

Association of single nucleotide polymorphisms in Neuropeptide Y (NPY) and Phosphoglycerate Mutase 2 (PGAM2) genes with growth traits in rabbits

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