Effects of Various Anaesthetic Techniques on Haemodynamic Stability and Inflammatory Cytokine (IL-6) Level in Patients Undergoing Breast Cancer Surgery

Abstract

Introduction: Multimodal anaesthesia techniques include regional anaesthesia in the form of paravertebral block and various anaesthetic drugs which acts on different sites of pain pathway with different mechanism of action, results in good quality of analgesia with minimal side effects. They improve recovery along with early mobilization and rehabilitation and early resumption. This technique lowers the level of inflammatory cytokines. Due to this we aim to evaluate the effects multimodal anaesthesia technique on level of IL-6 inflammatory cytokines in breast carcinoma surgery. Material and Methods: Patients were randomized into following three groups (n=30 in each group) using a computer generated random number tables. Group I: paracetamol 10 mg/ kg, Group II: paracetamol at 10 mg/kg and dexmedetomidine 0.5μg/kg, Group III: paracetamol 10 mg/kg, dexmedetomidine 0.5 μg/kg and paravertebral block with levobupivacaine. Fentany (2 μg/kg) with general anaesthesia were common in all three groups. Statistical Analysis: All the categorical data was compared by using student "t" test, chi-square test and parametric data by analysis of variance (ANOVA). Results: Patients of group III was haemodynamically more stable as compared to group II and I. IL-6 level was 358.15, in group I, 354 in group II and 346.65 in group III preoperatively while 324.85 in group I, 320.95 in group II, 278.35 in group III after 2 hour surgery. IL-6 level was significantly different in group III as compared to group II and group I postoperatively. Conclusion: Multimodal approach is a better anesthetic technique in terms of hemodynamic stability with decreased levels of IL-6 inflammatory cytokines.