Effects of various drugs on bladder function in conscious rats.

Morikawa, Kouji; Ichihashi, Miki; Kakiuchi, Masato; Yamauchi, Toshie; Kobayashi, Hideo; Ito, Yasuo; Gomi, Yasuo

doi:10.1254/jjp.50.369

Cited by 62 publications

(40 citation statements)

References 18 publications

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“…There is the possibility that the anes thetic agent can alter synaptic transmission, and urethral catheterization precludes any study of the synergism between bladder con traction and sphincter relaxation. To avoid these limitations, attention has been devoted to the establishment of cystometrography in a conscious rat model (9)(10)(11). In our previous report (11), we have described cystometro graphy in conscious rats placed in a restrain ing cage, which is thought to be a useful model for evaluating the effects of drugs on bladder function.…”

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confidence: 99%

Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.

et al. 1990

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Abstract-Intravesical instillation of xylene (30-50%) produced detrusor hyper reflexia characterized by a decrease in both the bladder capacity (time to micturition in the cystometrogram) and the urine volume in conscious rats placed in a restraining cage. At this time, the bladder tissue showed evidence of experimental cystitis with degradation of the epithelium and edema and hemorrhage in the submucosa, and a slight increase in the content of prostaglandin E2, which stimulates directly and/or indirectly capsaicin-sensitive sensory fibers. In addition, the bladder exhibited high amplitude spontaneous activity, but the bladder contractions induced by acetylcholine, substance P, prostaglandin E2 and capsaicin were not changed following intravesical instillation of xylene.In these hyperreflexic rats, atropine suppressed the amplitude of the micturition contraction and morphine increased the bladder capacity at similar doses as in sham-treated rats, while thiopental and indomethacin increased the bladder capacity at lower doses than in sham-treated rats. These findings indicated that intravesical instillation of xylene had produced detrusor hyperreflexia in conscious rats, and that the detrusor hyperreflexia is thought to be a useful model for evaluating the effect of a newly-developed agent on bladder function.

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Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.

et al. 1990

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“…11 However, during the first day after catheter implantation, this irritative change in bladder activity is not evident. 12,13 In this study, we inserted the catheter only a few hours before the CMG assessment to minimize the possibility of bladder irritation.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of action of sacral nerve stimulation using a transdermal

Elkelini

Pravidivyi

Hassouna

2013

CUAJ

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Introduction: Sacral neuromodulation (SNM) is an effective treatment modality for several urological problems, including neurogenic bladder. However, the invasiveness of this technique makes it unsuitable for many patients. We present a novel transdermal amplitude-modulated signal (TAMS) that may provide a non-invasive alternative to implantable SNM to treat neurogenic detrusor overactivity (NDO). Methods: In this study, we investigated the mechanism of action of non-invasive SNM using TAMS on our established spinal cord injury (SCI) animal model. We demonstrated that spinally transected rats develop urinary bladder hyper-reflexia after 3 weeks of SCI, indicated by the presence of uninhibited contractions, increased resting pressure, increased threshold pressure and increased maximum voiding pressure. Results: Short-term neurostimulation affected urodynamics parameters by significantly reducing the threshold pressure (p = 0.02). Spinal transection also increased calcitonin gene-related protein (CGRP) concentration in the L6 dorsal root ganglia; whereas, neurostimulation significantly reduced CGRP concentration in L6 (p = 0.03). Conclusion: TAMS caused a reduction in NDO by inhibiting C-fibre activity.

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“…Atropine is considered to act on the micturition center(s) and/or bladder mecha noreceptors as well as the muscarinic re ceptors in the bladder smooth muscle in anesthetized rats (6,7). Atropine decreased the micturition pressure in restrained denervated rats at almost the same dose as that in restrained-intact rats or anesthetized rats.…”

Section: Discussionmentioning

confidence: 99%

“…Atropine decreased the micturition pressure in restrained denervated rats at almost the same dose as that in restrained-intact rats or anesthetized rats. Indomethacin is considered to act on the micturition center(s) in the sacral cord and/ or brain stem or on bladder mechanoreceptors (7)(8)(9). Indomethacin increased the bladder capacity in restrained-denervated rats at a dose similar to that in restrained-intact rats or anesthetized rats.…”

Section: Discussionmentioning

confidence: 99%

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Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.

et al. 1990

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Abstract-We evaluated the effects of various intravenously administered drugs, which had been shown to influence bladder function in anesthetized and/or con scious rats, on the cystometrogram in conscious restrained-denervated rats (pro duced by transection of the hypogastric nerve) placed in a restraining cage in com parison to those in conscious restrained-intact rats (with the hypogastric nerve intact) placed in a restraining cage. The bladder capacity in the restrained denervated rats was smaller than that in restrained-intact rats and did not change when they were transferred to a wide cage, but the bladder capacity of the restrained intact rats decreased following transfer to the wide cage. Therefore, the activity of the hypogastric nerve in conscious rats appears to be stimulated by restraint. Atropine suppressed the amplitu..,de of the micturition contraction (time to micturi tion in the cystometrogram).In the restrained-denervated rats, thiopental and indomethacin increased the bladder capacity at almost the same doses as those in restrained-intact rats, but it took a higher dose of morphine to increase the bladder capacity than in restrained-intact rats. These findings suggest that cystometro graphy in restrained-denervated rats is a useful method for evaluating the effect of a newly developed agent on bladder function without any influence from the hypogastric nerve.

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Effects of various drugs on bladder function in conscious rats.

Cited by 62 publications

References 18 publications

Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.

Detrusor hyperreflexia induced by intravesical instillation of xylene in conscious rats.

Mechanism of action of sacral nerve stimulation using a transdermal

Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.

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