1985
DOI: 10.1152/ajpgi.1985.248.4.g432
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Effects of varying hematocrit on intestinal oxygen uptake in neonatal lambs

Abstract: We chronically catheterized 15 newborn lambs (9.5 +/- 2.8 days) and measured intestinal blood flow (Qi) by the radionuclide microsphere technique at hematocrit levels ranging from 10 to 55%. Seven animals were made progressively anemic and eight polycythemic by means of exchange transfusions. Using the Fick principle, we calculated intestinal oxygen delivery (Di o2), oxygen consumption (Vi o2), and oxygen extraction. Initial base-line values were Qi = 195.5 ml . min-1 . 100 g intestine-1, Di o2 = 22.1 ml . min… Show more

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Cited by 8 publications
(7 citation statements)
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“…The effect of oil infusion on liver plasma flow in the present study was attributed to metabolizable energy (ME) intake during the blood sampling period or to neural or hormonal responses to postruminal oil infusion . While oil infusion decreased daily DMI in our study, the reduction occurred late in the day and before the morning milking, and thus feed DMI during the period of sampling was not affected (Holzman et al, 1985). In humans, increased splanchnic blood flow following ingestion of oil was accompanied by an increase in blood PCV, suggesting other factors are responsible for the increased flow observed (Brundin, 1998).…”
Section: Packed-cell Volume Blood Flow and Blood Gas Exchangecontrasting
confidence: 45%
“…The effect of oil infusion on liver plasma flow in the present study was attributed to metabolizable energy (ME) intake during the blood sampling period or to neural or hormonal responses to postruminal oil infusion . While oil infusion decreased daily DMI in our study, the reduction occurred late in the day and before the morning milking, and thus feed DMI during the period of sampling was not affected (Holzman et al, 1985). In humans, increased splanchnic blood flow following ingestion of oil was accompanied by an increase in blood PCV, suggesting other factors are responsible for the increased flow observed (Brundin, 1998).…”
Section: Packed-cell Volume Blood Flow and Blood Gas Exchangecontrasting
confidence: 45%
“…These investigators did not compare nonfed and fed subjects at the same time on the first postnatal day, as was carried out here, although the substantial increase in baseline intestinal blood flow and oxygen uptake by postnatal day 3 and its decline by postnatal day 30 was first described by these workers (6)(7)(8)(9). It is clear that baseline hemodynamic and oxygenation parameters dramatically change during early postnatal life in swine, a process also noted in other species (11,16).…”
Section: Discussionmentioning
confidence: 86%
“…Arterial oxygen contents, organ blood flows, organ oxygen deliveries, as well as hepatic oxygen consumption (~~0~) and hepatic oxygen extraction (VL02/DL02) and cardiac output were plotted against hematocrit. We defined the mathematical relationships between independent and dependent variables using the least squares method based on covariance analysis (16). The advantage of this statistical method is that it takes into account the individual responses of the animals.…”
Section: Methodsmentioning
confidence: 99%