Effects of vecuronium and rocuronium in antagonistic laryngeal muscles and the anterior tibial muscle in the cat

Abstract

In cats, the time course of neuromuscular blockade after vecuronium and rocuronium differs in antagonistic laryngeal muscles. The protective laryngeal function of glottis closure recovers later than vocal cord abduction after both vecuronium and rocuronium.

Neuromuscular blockade at the larynx, the diaphragm and the corrugator supercilii muscle: a review

“…In cats, 28 onset and recovery after vecuronium and rocuronium were the same for the posterior cricoarytenoid muscles and the tibialis muscle. The lateral cricoarytenoid muscle and the thyroarytenoid muscle had a slower onset and a more prolonged recovery.…”

Prevention of laryngospasm with rocuronium in cats: a dose-finding study

“…The reported ED 90 of rocuronium in cats approximates 0.09 mg kg −1 (Michalek‐Sauberer et al. ). Although the ED 90 of rocuronium was not calculated in the present study, the administration of 0.1 mg kg −1 resulted in complete block in six cats, and incomplete block (75% and 90%) in the remaining two cats, a result that broadly agrees with an ED 90 of 0.09 mg kg −1 .…”

“…When the same dose was used to assist intubation, mechanical ventilation was needed for 10-28 minutes (Moreno-Sala et al 2013). However, as the effective dose 90 (ED 90 ; the dose depressing twitch by 90%) of rocuronium approximates 0.09 mg kg À1 (Michalek-Sauberer et al 2000), it is possible that doses lower than 0.6 mg kg À1 could be used to prevent laryngospasm and aid tracheal intubation while causing a much shorter period of apnea. Moreover, the muscles responsible for ventilation appear to be more resistant to the effects of NMBAs than are limb muscles, and hence effective ventilation returns prior to the complete recovery of neuromuscular function in the limbs of dogs and cats (Martin-Flores et al 2014, 2015.…”

A clinical study of the effects of rocuronium in isoflurane-anaesthetized cats

“…In experimental studies in cats anaesthetized with barbiturates, rocuronium doses of 0.09 mg kg )1 (Michalek-Sauberer et al 2000) and 0.25 mg kg )1 (Muir et al 1989) produced 95% blockade. This degree of relaxation is comparable with the effect found in the study reported here but at much lower doses.…”

“…In experimental studies in cats anaesthetized with barbiturates, rocuronium doses of 0.09 mg kg −1 (Michalek‐Sauberer et al. 2000) and 0.25 mg kg −1 (Muir et al.…”