Effects of venlafaxine and fluoxetine on lymphocyte subsets in patients with major depressive disorder: A flow cytometric analysis

Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy

“…Previous reports have suggested that antidepressant treatment affects lymphocyte subset populations; however, most of these studies were not designed to study prediction of treatment response (Basterzi et al 2010;Frick et al 2009;Hernandez et al 2010). Earlier studies showed intact levels of CD8 + T cells in MDD patients compared with control subjects (Basterzi et al 2010;Schlatter et al 2004), a finding which is also consistent with our results.…”

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“…We are aware of one human study directly comparing the effects of antidepressants on adaptive immune factors. In depressed adult subjects, CD45 values decreased with venlafaxine, however, there was no difference with fluoxetine [68]. We are not aware of other pre-clinical studies which compare the effects of antidepressants on the adaptive immune system.…”

“…The study by Basterzi et al [68] explored the effect of venlafaxine and fluoxetine on lymphocyte subsets (CD3, CD4, CD8, CD16/56, CD19, CD45, anti-HLA-DR) in MDD patients over 6 weeks. 69 MDD patients and 36 healthy controls were involved in this study.…”

Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models

“…The antidepressant aripiprazole has effectively treated irritability, hyperactivity and stereotypy in two large randomized controlled trials of ASD children [124], and is reported to prevent microglial activation, reduce reactive oxygen species and suppress pro-inflammatory cytokines [125]. Fluoxetine, another antidepressent, exhibits several effects on immune function [126][127][128][129] and has reduced repetitive behaviors in a double-blind placebo-controlled trial of adults with ASD [130]. The beneficial effects of the acetylcholinesterase inhibitors, galantamine and donepezil on reducing social withdrawal, irritability and inattention in children with autism [131,132] are believed to be due in part to activation of the cholinergic anti-inflammatory pathway [133].…”