Effects of Vernonia amygdalina Leaf on Nutritional and Biochemical Parameters in Alloxan-Induced Diabetic Rats

Abstract

The effects of Vernonia amygdalina leaf on the nutritional and biochemical parameters in alloxan-induced diabetic rat were investigated. Vernonia amygdalina (VA) leaf was squeeze-washed, dried, pulverized and mixed with standard feed at 2.5%, 5%, 10% and 20%. The proximate nutrient composition of the standard and prepared rations was determined. The Vernonia amygdalina incorporated rations and standard ration were fed to alloxan-induced diabetic rats for 70 consecutive days. Thereafter the nutritional and biochemical parameters as well as the histopathology of pancreas vital organs of the treated rats were determined. The Vernonia Amygdalina at 2.5% inclusion rate significantly (p < 0.05) reversed the nutritional indices and biochemical parameters which were compromised in diabetic rats fed with standard ration alone. The VA also reversed the degenerative changes in the pancreatic islet induced by alloxan. Vernonia Amygdalina has potent antidiabetic activity and its incorporation in excess of 5% in the diet should be avoided.

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

“…The diets were formulated as described by Amaechi et al [10]. Briefly, standard diet containing 83% corn starch, 10% casein, 2% vegetable oil, 3% rice bran and 2% vitamin and mineral mix was prepared.…”

Evaluation of the effect of ethanol leaf extract of Vernonia amygdalina on the Testicle of Diabetic Wistar Rats

“…Research has shown that bitter leaf is an embodiment of valuable compounds such as saponins, flavonoids, alkaloids, and tannins etc [3]. Extract of V. amygdalina subjected to hydrodistillation revealed the presence of linoleic acid and oleic acid which are both essential [4] as well as α-pinene and eucalyptus linalool [5].…”