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Background: This study assessed the level of satisfaction of patients with TB implementation in selected DOTS accredited facilities. Methodology: A comparative cross-sectional analytic study involving rural and urban areas implementing DOTS for TB in Anambra State was done. A total of 354 respondents (177 per sub population) were enrolled in the study. By exit interview respondents were administered the questionnaire that bordered on services rendered and cost implications of accessing treatment at the facilities. Results: A total of 162(91.5%) rural respondents were satisfied with appropriateness of working hours compared to 166(93.8%) participants in urban areas. Also 141(79.7%) respondents in rural areas were satisfied with waiting time compared to 155(87.6%) in urban areas and this was statistically significant p<0.004. For the cleanliness of the specimen bottle 138(77.8%) rural respondents compared to 148(83.6%) in urban areas were satisfied and this was statistically significant, p<0.001. Majority of the urban respondents 123(68.9%) were satisfied with respect offered by health workers compared to rural 114(64.4%), and this was also significant, p<0.000. Concerning cost incurred and information given by health workers more urban respondents 5(2.8%) were dissatisfied compared to rural 2(1.1%) though not statistically significant p= 0.378. However, satisfaction was slightly higher in urban (82.8%) compared to rural (80.8%) respondents, while the overall satisfaction in this study was 81.8%. Conclusion: Patient`s satisfaction is a panacea for successful DOTS implementation. We therefore recommend that satisfaction could be improved by provision patient-centred requests such as provision of multivitamins, transport, food among others to help improve DOTS because it will encourage attendance and adherence with better outcomes.

Aim: The Complete Blood Count (CBC) among hypertensive subjects in Isiala Mbano, Imo State, Nigeria West Africa were studied. Methodology: The American College of Cardiology/American Heart Association (2017) current definition of hypertension was used to ascertain, diagnoses and assigned eighty (80)hypertensive subjects after three different consecutive blood pressure check into tests groups. Other blood pressure measures such as pulse pressure and mean arterial pressure were calculated appropriately. Venous blood samples were collected with 5mls syringe and immediately emptied into EDTA container for complete blood count analysis. Results: The results showed increase in RBC count, HB, PCV and decrease in MCV among hypertensive subjects compared with normotensive subjects. It was statistically insignificant in all age groups. No changes were seen in MCHC and MCH. The results also, showed increase in PLTS count. The increase in PLTS count was statistically significant at P<0.05 and <0.001 among hypertensive age groups 36-65yrs and >66yrs respectively. Increase in PLTS count among 20-35yr age group was not significant. There were increase in WBC count among hypertensive subjects compared with normotensive subjects in all age groups. It was statistically significant at P<0.05 and <0.001 among hypertensive age groups 36-50yrs and >66yrs respectively. Neutrophil was increased in all age groups and was statistically significant at P<0.05 except 20-35yr age group. No changes were seen on lymphocytes, monocytes, eosinophils and basophils. Conclusion: Haematological parameters investigated could predict possible cardiovascular abnormalities such as hypertension.

The aim of this study was to evaluate the hepato-toxic potential of methanol seed kernel extract of Mangifera indica (mango). Dry mango seeds were broken to release the kernels which were subsequently dried at room temperature prior to grinding to fine powder. 500 g of powdered plant sample was developed into extract with the aid of a standard analytical procedure. Twenty (20) adult male albino rats divided into four (4) groups of five rats each. Group I (normal control) which was fed normal rat chow and water ad-libitum. Group II, III and IV were administered 100, 200 and 300 mg/kg of extract respectively for 21 days after which rats were sacrificed and blood sample collected and analysed for the activity of serum hepatomarkers ; Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and Alanine aminotransferase (ALT) was evaluated using standard procedures. Result obtained from the study showed that administration of 100 and 200 mg/kg bw did not increase the activity of the serum hepatomarkers. However, a contrary observation was made on the activity of serum hepatomarkers in rats administered with 400 mg/kg of MSKE inferring that methanol seed kernel extract of Mangifera indica (mango) could contain a hepatotoxic agent which can only elicit damage in large doses.