Effects of vinblastine on microvascular anastomosis healing in diabetic rats

Karşıdağ, Semra

doi:10.3944/aott.2011.2430

Cited by 1 publication

(3 citation statements)

References 13 publications

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“…In addition to surgical and technical factors, the success of microsurgery is closely related to patients' health status, health problems, and medications. Several studies have examined the effects of various substances, including low-molecular-weight heparin, steroids, sildenafil, and vinblastine, on enhancing microvascular anastomosis patency [1][2][3][4][5][6]. However, the benefits of these substances have not been proven.…”

Section: Fig 1 Organized Thrombusmentioning

confidence: 99%

“…The patency of microvascular anastomoses is adversely affected by local and systemic factors [1]. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common causes of decreased anastomosis Antithrombotic effect of epigallocatechin gallate on the patency of arterial microvascular anastomoses patency [1][2][3][4]. Dextran, heparin, low-molecular-weight heparin, and steroids are commonly administered in clinical practice to prevent thrombus formation.…”

Section: Introductionmentioning

confidence: 99%

“…Dextran, heparin, low-molecular-weight heparin, and steroids are commonly administered in clinical practice to prevent thrombus formation. Several drugs, including vinblastine, sildenafil, and botulinum toxin, have been used to increase anastomosis patency in experimental studies; however, the clinical applications of these drugs are currently limited [1,2,5,6].…”

Section: Introductionmentioning

confidence: 99%

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Antithrombotic effect of epigallocatechin gallate on the patency of arterial microvascular anastomoses

et al. 2019

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Background Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea ( Camellia sinensis ). This study investigated the effects of EGCG on the structure of vessel tips used in microvascular anastomoses and evaluated its effects on thrombus formation at an anastomotic site. Methods Thirty-six adult male Wistar albino rats were used in the study. The right femoral artery was cut and reanastomosed. The rats were divided into two groups (18 per group) and were systemically administered either EGCG or saline. Each group were then subdivided into three groups, each with six rats. Axial histological sections were taken from segments 1 cm proximal and 1 cm distal to the microvascular anastomosis site on days 5, 10, and 14. Results Thrombus formation was significantly different between the EGCG and control groups on day 5 (P=0.015) but not on days 10 or 14. The mean luminal diameter was significantly greater in the EGCG group on days 5 (P=0.002), 10 (P=0.026), and 14 (P=0.002). Intimal thickening was significantly higher on days 5 (P=0.041) and 10 (P=0.02). Conclusions EGCG showed vasodilatory effects and led to reduced early thrombus formation after microvascular repair. Similar studies on venous anastomoses and random or axial pedunculated skin flaps would also contribute valuable findings relevant to this topic.

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