Effects of vinca alkaloids on rat parotid and submandibular glands function in vivo

Dehpour, Ahmad Reza; Ghafourifar, Pedram; Madani, Farideh; Mousavizadeh, Kazem; Abdollahi, Mohammad

doi:10.1016/0306-3623(94)00206-3

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…This is reflected by the increase in protein carbonyl contents as an excellent marker of protein oxidation and lipid peroxidation [ 46 ]. This study showed that exposed subjects presented significantly higher levels of LPO and PrC with respect to the controls, in agreement with earlier studies [ 37 , 42 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Nevertheless, other studies indicated no difference in LPO between exposed and control groups [ 39 , 44 , 55 ].…”

Section: Discussionsupporting

confidence: 93%

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

Ahmadi

Mandegary

Jamshidzadeh

et al. 2018

Toxics

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The widespread use of pesticides in agriculture represents a threat to the human populations exposed to them. In this cross-sectional study, the hematological and biochemical parameters, plasma cholinesterase (PChE) activity, oxidative stress, genotoxicity, and NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism were measured in 100 greenhouse workers occupationally exposed to pesticide mixture and 104 normal healthy controls. There was a decrease in erythrocytes (5.45%, p = 0.026) and hemoglobin (3.26%, p = 0.025), and an increase in mean corpuscular hemoglobin (3.54%, p = 0.013) in the exposed workers. Sprayers showed a reduction in PChE (23%) and GSH (50%) levels, and an increase in lipid peroxidation (LPO) (55%), protein carbonyl (145%), Superoxide dismutase activity (61%), and total antioxidant capacity (35%) (p < 0.001 for all parameters but LPO: p = 0.009). Genotoxicity parameters were significantly high in the exposed cases (for all parameters: p < 0.001 but tail length: p = 0.002). There was a significant correlation between oxidative stress and genotoxicity parameters, and also between these biomarkers and PChE activity. The NQO1 C609T polymorphism was not significantly associated with studied biomarkers. The findings indicate that occupational exposure to a mixture of pesticides can induce hematotoxicity, oxidative stress, and genotoxicity in greenhouse workers.

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Section: Discussionsupporting

confidence: 93%

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

Ahmadi

Mandegary

Jamshidzadeh

et al. 2018

Toxics

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“…There are studies reported that total protein increases, decreases, or does not change during chemotherapy [31,32,[36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Effects of chemo-therapeutic drugs used in head and neck cancers on sub-mandibular glands of rats

Yurdabakan¹,

Özcan²,

Solakoğlu³

2022

jos

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Introduction: Chemo-therapeutic drugs can cause morphological damages to the salivary glands.Objectives: This study aimed to analyze and elucidate 5-fluorouracil (5-FU), cisplatin, methotrexate (MTX), and adriamycin (ADR)-induced morphological changes on submandibular glands (SMGs) of the rats. Material and methods: Forty male Wistar albino rats were divided into five groups, with 8 rats per group. In the control group, 1 ml/kg 0.9% sterile saline solution; in the second group, 100 mg/kg dose of 5-FU; in the third group, 5 mg/kg dose of cisplatin; in the fourth group, 15 mg/kg dose of MTX; in the fifth group, 15 mg/kg dose of ADR were injected once a day for three consecutive days intra-peritoneally. In all groups, SMGs were excised, histopathological analyses were done using a light microscope, and total protein content was analyzed according to Lowry method. Data were examined using analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, and Dunn's tests. Results were evaluated at 95% confidence interval and significance level of p < 0.05. Results: There was a statistically significant decrease in gland weight and total protein content of the 5-FU, ADR, and cisplatin groups compared to that of the control (p < 0.001). However, the decrease in gland weight and total protein content of MTX group was not statistically significant (p > 0.05). Acinus areas of 5-FU, ADR, cisplatin, and MTX groups were lower than that of the control significantly (p < 0.001). Conclusions: According to morphological parameters of our study, the most toxic effects were found to be caused by 5-FU, followed by ADR and cisplatin, while MTX presented the least toxic effects on the rats' SMGs.

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Xerostomia and hypofunction of the salivary glands in cancer therapy

Jensen

Pedersen

Reibel

et al. 2003

Support Care Cancer

171

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This review presents data from the literature on oral adverse reactions from the perspectives of subjective feelings of dry mouth (xerostomia) and objective measures of salivary gland hypofunction during and after cancer therapy. Special emphasis is paid to the mechanisms behind xerostomia, impaired saliva secretion and changes in the composition of saliva and to how these relate to radiation therapy involving the salivary glands and to systemic chemotherapy. The oral complications that relate to such iatrogenic changes in salivary gland function are also discussed. Xerostomia and hypofunction of the salivary glands in cancer therapy Salivary gland physiologyThe mixed fluid in the mouth is derived from the major salivary glands, which account for more than 90% of the fluid production. In the unstimulated state about twothirds of the volume of whole saliva is produced by the submandibular glands (mixed, but mainly serous type).

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Effects of vinca alkaloids on rat parotid and submandibular glands function in vivo

Cited by 6 publications

References 41 publications

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

Effects of chemo-therapeutic drugs used in head and neck cancers on sub-mandibular glands of rats

Xerostomia and hypofunction of the salivary glands in cancer therapy

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