Xerostomia and hypofunction of the salivary glands in cancer therapy

Jensen, Siri Beier; Pedersen, Anne Marie Lynge; Reibel, Jesper; Nauntofte, Birgitte

doi:10.1007/s00520-002-0407-7

Cited by 171 publications

(125 citation statements)

References 162 publications

(162 reference statements)

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“…Individuals commonly produce 0.3 ml/min of saliva without stimulation; when secretion is less than or equal to 0.1 ml/min, it is characterised as hyposalivation [14]. …”

Section: Methodsmentioning

confidence: 99%

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

2017

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BackgroundOral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG).MethodsThe study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy. Twenty-eight patients were male and 17 female, ranging from 3 months to 18 years old.ResultsThe results show an increase in the number of mucositis cases and a decrease in xerostomia cases after the initiation of treatment, and other oral lesions were also found in low numbers.ConclusionsIt is possible to avoid oral complications by maintaining a good oral health, and reducing infectious outbreaks. It is also feasible to obtain an early diagnosis of, and treat these oral complications, preventing them from following a more severe clinical course that may negatively affect the individual’s treatment. This outcome requires the presence of a dental surgeon on the multidisciplinary cancer treatment team.

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“…Individuals commonly produce 0.3 ml/min of saliva without stimulation; when secretion is less than or equal to 0.1 ml/min, it is characterised as hyposalivation [14]. …”

Section: Methodsmentioning

confidence: 99%

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

2017

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“…The FDA-approved drug amifostine has been extensively used in trials as a preventative treatment to ameliorate the side effects that follow radiotherapy [7]–[9]. Although a reduction of xerostomia has been observed with amifostine, the number of side effects and serious conditions such as hypotension, Stevens-Johnsons syndrome, and hypersensitivity [10], [11], often influence patients’ compliance.…”

Section: Introductionmentioning

confidence: 99%

Label-Retaining Cells in the Adult Murine Salivary Glands Possess Characteristics of Adult Progenitor Cells

et al. 2014

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Radiotherapy is the primary treatment for patients with head and neck cancer, which account for roughly 500,000 annual cases worldwide. Dysfunction of the salivary glands and associated conditions like xerostomia and dysphagia are often developed by these patients, greatly diminishing their life quality. Current preventative and palliative care fail to deliver an improvement in the quality of life, thus accentuating the need for regenerative therapies. In this study, a model of label retaining cells (LRCs) in murine salivary glands was developed, in which LRCs demonstrated proliferative potential and possessed markers of putative salivary progenitors. Mice were labeled with 5-Ethynyl-2′-deoxyuridine (EdU) at postnatal day 10 and chased for 8 weeks. Tissue sections from salivary glands obtained at the end of chase demonstrated co-localization between LRCs and the salivary progenitor markers keratin 5 and keratin 14, as well as kit mRNA, indicating that LRCs encompass a heterogeneous population of salivary progenitors. Proliferative potential of LRCs was demonstrated by a sphere assay, in which LRCs were found in primary and secondary spheres and they co-localized with the proliferation marker Ki67 throughout sphere formation. Surprisingly, LRCs were shown to be radio-resistant and evade apoptosis following radiation treatment. The clinical significance of these findings lie in the potential of this model to study the mechanisms that prevent salivary progenitors from maintaining homeostasis upon exposure to radiation, which will in turn facilitate the development of regenerative therapies for salivary gland dysfunction.

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“…Humans typically secrete 0.5–1.5 liters of saliva into the oral cavity each day in response to sympathetic, parasympathetic and hormonal stimulation [3, 7]. The underlying fluid secretion mechanism is highly conserved in the different salivary glands and perhaps other exocrine glands such as sweat and lacrimal glands.…”

Section: Introductionmentioning

confidence: 99%

Ca2+-dependent K+ channels in exocrine salivary glands

2014

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In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca2+-dependent K+ channels take part in key functions including membrane potential regulation, fluid movement and K+ secretion in exocrine glands. Two K+ channels have been identified in exocrine salivary glands: 1) a Ca2+-activated K+ channel of intermediate single channel conductance encoded by the KCNN4 gene; and, 2) a voltage- and Ca2+-dependent K+ channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca2+-dependent K+ channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca2+-dependent K+ channels by protein-protein interactions that may significantly impact exocrine gland physiology.

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Xerostomia and hypofunction of the salivary glands in cancer therapy

Cited by 171 publications

References 162 publications

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

Label-Retaining Cells in the Adult Murine Salivary Glands Possess Characteristics of Adult Progenitor Cells

Ca2+-dependent K+ channels in exocrine salivary glands

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