Effects of virtual reality combined cognitive and physical interventions on cognitive function in older adults with mild cognitive impairment: A systematic review and meta-analysis

Yan, Mingli; Zhao, Yawei; Meng, Qiuyan; Wang, Shuo; Ding, Yiwen; Liu, Qian; Yin, Hao; Chen, Li

doi:10.1016/j.arr.2022.101708

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…However, there was no significant improvement in the subcategories such as global cognition (MD = −1.15, 95% CI: −2.83 to 0.53), executive function (MD = −2.56, 95% CI: −8.94 to 3.82), working memory (MD = 0.08, 95% CI: −0.93 to 1.10), memory function (MD = −0.26, 95% CI: −0.73 to 0.22), and attention (MD = −0.61, 95% CI: −1.26 to 0.05) when compared with the control group. Our results differed from those reported in previous meta-analyses [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], which showed significant improvements in global cognition. A previous meta-analysis showed significant improvements in executive function [ 19 , 20 , 21 ] and memory function [ 15 , 19 ].…”

Section: Discussioncontrasting

confidence: 99%

“…A previous meta-analysis showed significant improvements in executive function [ 19 , 20 , 21 ] and memory function [ 15 , 19 ]. However, another meta-analysis reported no positive effects on memory function [ 17 , 20 , 21 ], execution function [ 17 ], and attention [ 17 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…With the development of VR technology, many studies have been conducted on MCI, and numerous systematic reviews have been published [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Systematic reviews have suggested that semi-immersive VR was more effective than immersive VR, and it showed significant improvement in global cognitive function and short-term memory.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Application of Virtual Reality in the Rehabilitation of Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Kim

Jung

Lee

2022

Vision

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This review aimed to quantify the effect of therapeutic application of virtual reality (VR) on cognitive function in individuals with mild cognitive impairment (MCI). We searched for randomized controlled trials involving VR in the interventions provided to individuals with MCI. After searching four international electronic databases, we analyzed six studies involving 279 individuals with MCI. RevMan 5.4 was used for quality assessment and quantitative analysis. Therapeutic application of VR in individuals with MCI resulted in a significant improvement in cognitive function (mean difference = −1.46; 95% confidence interval: −2.53 to −0.39; heterogeneity: χ2 = 970.56, df = 18, I2 = 98%; and overall effect: Z = 2.67, p = 0.008). However, there was no significant improvement in the subcategories such as global cognition, working memory, executive function, memory function, and attention. In conclusion, feedback stimulation through VR has a potential value in improving cognitive function in individuals with MCI. However, on the basis of the results of the subcategories, a personalized VR program is required for the individual subcategories of cognitive function.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic Application of Virtual Reality in the Rehabilitation of Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Kim

Jung

Lee

2022

Vision

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“…This may suggest that the VR-based cognitive training program may hold a limited effect on other speci c cognitive functions, such as processing speed, executive function, and verbal memory. However, previous meta-analyses reported no positive effects on memory [40][41][42], execution function [40], and attention [40,42] among patients with MCI.…”

Section: Comparison With Prior Workmentioning

confidence: 86%

Virtual reality-based training may improve visual memory and some aspects of sustained attention among healthy older adults – preliminary results of a randomized controlled study

Szczepocka,

Mokros,

Kaźmierski

et al. 2023

Preprint

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Background/Aims Older age and cognitive inactivity have been associated with cognitive impairment, which in turn is linked to economic and societal burdens due to the high costs of care, especially for care homes and informal care. Emerging non-pharmacological interventions using new technologies, such as virtual reality (VR) delivered on a head-mounted display (HMD), might offer an alternative to maintain or improve cognition. The study aimed to evaluate the efficacy and safety of a VR-based Digital Therapeutics application for improving cognitive functions among healthy older adults. Methods Seventy-two healthy seniors (experimental group N = 35, control group N = 37), aged 65–85 years, were recruited by the Medical University of Lodz (Poland). Participants were randomly allocated to the experimental group (a VR-based cognitive training which consists of a warm-up module and three tasks, including one-back and dual-N-back) or to the control group (a regular VR headset app only showing nature videos). The exercises are performed in different 360-degree natural environments while listening to a preferred music genre and delivered on a head-mounted display (HMD). The 12-week intervention of 12 minutes was delivered at least three times per week (36 sessions). Compliance and performance were followed through a web-based application. Primary outcomes included attention and working memory (CNS-Vital Signs computerized cognitive battery). Secondary outcomes comprised other cognitive domains. Mixed linear models were constructed to elucidate the difference in pre- and post-intervention measures between the experimental and control groups. Results The users performed, on average, 39.8 sessions (range 1-100), and 60% performed more than 36 sessions. The experimental group achieved higher scores in the visual memory module (B = 7.767, p = 0.011) and in the one-back continuous performance test (in terms of correct responses: B = 2.057, p = 0.003 and omission errors: B=-1.950, p = 0.007) than the control group in the post-test assessment. The results were independent of participants' sex, age, and years of education. The differences in CNS Vital Signs' global score, working memory, executive function, reaction time, processing speed, simple and complex attention, verbal memory, cognitive flexibility, motor speed, and psychomotor speed were not statistically significant. Conclusions VR-based cognitive training may prove to be a valuable, efficacious, and well-received tool in terms of improving visual memory and some aspect of sustainability of attention among healthy older adults. Final conclusions will be drawn after the analysis of the target sample size. Trial registration: Clinicaltrials.gov ID NCT05369897

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“…The rate of mean annual conversion to dementia in MCI (10%) is far higher than that in the general population (1-2%) (Yan et al, 2022). With the consideration of reversible characteristic of MCI, this stage would provide an optimal window to the early prevention and intervention of dementia.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of biomarkers based on cellular senescence in mild cognitive impairment

S.K.

Xia

Wang

et al. 2023

Front. Aging Neurosci.

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BackgroundMild cognitive impairment (MCI), a syndrome defined as decline of cognitive function greater than expected for an individual’s age and education level, occurs in up to 22.7% of elderly patients in United States, causing the heavy psychological and economic burdens to families and society. Cellular senescence (CS) is a stress response that accompanies permanent cell-cycle arrest, which has been reported to be a fundamental pathological mechanism of many age-related diseases. This study aims to explore biomarkers and potential therapeutic targets in MCI based on CS.MethodsThe mRNA expression profiles of peripheral blood samples from patients in MCI and non-MCI group were download from gene expression omnibus (GEO) database (GSE63060 for training and GSE18309 for external validation), CS-related genes were obtained from CellAge database. Weighted gene co-expression network analysis (WGCNA) was conducted to discover the key relationships behind the co-expression modules. The differentially expressed CS-related genes would be obtained through overlapping among the above datasets. Then, pathway and GO enrichment analyses were performed to further elucidate the mechanism of MCI. The protein–protein interaction network was used to extract hub genes and the logistic regression was performed to distinguish the MCI patients from controls. The hub gene-drug network, hub gene-miRNA network as well as transcription factor-gene regulatory network were used to analyze potential therapeutic targets for MCI.ResultsEight CS-related genes were identified as key gene signatures in MCI group, which were mainly enriched in the regulation of response to DNA damage stimulus, Sin3 complex and transcription corepressor activity. The receiver operating characteristic curves of logistic regression diagnostic model were constructed and presented great diagnostic value in both training and validation set.ConclusionEight CS-related hub genes – SMARCA4, GAPDH, SMARCB1, RUNX1, SRC, TRIM28, TXN, and PRPF19 – serve as candidate biomarkers for MCI and display the excellent diagnostic value. Furthermore, we also provide a theoretical basis for targeted therapy against MCI through the above hub genes.

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Effects of virtual reality combined cognitive and physical interventions on cognitive function in older adults with mild cognitive impairment: A systematic review and meta-analysis

Cited by 15 publications

References 17 publications

Therapeutic Application of Virtual Reality in the Rehabilitation of Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Therapeutic Application of Virtual Reality in the Rehabilitation of Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Virtual reality-based training may improve visual memory and some aspects of sustained attention among healthy older adults – preliminary results of a randomized controlled study

Identification and validation of biomarkers based on cellular senescence in mild cognitive impairment

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