Effects of vitamin B 12 , folate, uric acid, and serum biomarkers of inflammation on bone mineral density in postmenopausal women

Beyazıt, Fatma; Pek, Eren

doi:10.5114/pm.2018.77305

Cited by 11 publications

(12 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it was reasonable that vitamin C might improve bone health. In this study, there were no significant associations of serum vitamins B12 and E levels with BMD, which was consistent with previous studies [ 32 , 33 ]. The potential mechanisms of serum folate, vitamins A and C levels on bone health are presented in Fig.…”

Section: Discussionsupporting

confidence: 93%

Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults

Liu

2021

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background The conclusions on the associations of specific vitamin levels with bone mineral density (BMD) were controversial. Therefore, the aims of this study were to examine the associations of serum vitamins levels with BMD and the modified effect of race/ ethnicity on these associations in the US adults. Methods This study was from the third National Health and Nutrition Examination Survey. All participants aged ≥18 years with complete data were eligible. Serum vitamins A, B9, B12, C, and E levels were assayed using the Quantaphase II Radioassay Kit (Bio-Rad). Dual-energy X-ray absorptiometry was employed to measure BMD, including femur neck and the total hip. Results There were 6023 participants included in the final analysis. Serum folate, vitamins A and C levels were positively associated with BMD. No significant associations of serum vitamins B12 and E levels with BMD were observed. There were positive associations of serum folate level (β = 0.00027 and 0.00032; and 95% CI: 0.00002–0.00057 and 0.00002–0.00063, respectively), vitamin A level (β = 0.01132 and 0.01115; and 95% CI: 0.00478–0.01787 and 0.00430–0.01799, respectively), and vitamin C level (β = 0.00027 and 0.00029; and 95% CI: 0.00012–0.00042 and 0.00013–0.00045, respectively) with BMD at femur neck and the total hip only in the Not Hispanic participants. Conclusion Elevated serum folate, vitamins A and C levels were associated with a higher BMD. Furthermore, sex and race/ ethnicity modified the associations of serum vitamins levels with BMD.

show abstract

Section: Discussionsupporting

confidence: 93%

Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults

Liu

2021

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…It is generally considered that physiological concentration of blood uric acid has an anti-osteoporosis effect. On the one hand, uric acid has a certain protective effect on bone metabolism, which is believed to be related to its antioxidant function (Ahn et al, 2013; Beyazit and Pek, 2018). Uric acid is also positively correlated with the level of parathyroid hormone (PTH) (Chikura et al, 2009; Hui et al, 2012) and can also affect bone metabolism by regulating the activity of 1α-hydroxylase.…”

Section: Discussionmentioning

confidence: 99%

High-Throughput Metabolomics Evaluate the Efficacy of Total Lignans From Acanthophanax Senticosus Stem Against Ovariectomized Osteoporosis Rat

Zhang

Sun

et al. 2019

Front. Pharmacol.

View full text Add to dashboard Cite

Postmenopausal osteoporosis (PMOP) is a common clinical illness in postmenopausal women, but there is no effective drug at present. Metabolomics approach was used to explore the potential biomarkers of PMOP and evaluate the efficacy and therapeutic targets of total lignans in the stem of Acanthophanax senticosus (ASSL) on the ovariectomized osteoporosis model rats. UPLC/MS and pattern recognition methods were used for serum metabolites discovery to illustrate the pathological mechanism of PMOP model rats, and then revealing the intervention effect of ASSL. The pattern recognition result showed that serum metabolic profiles of the sham operation group and the model group were clustered clearly, and 16 potential biomarkers were finally identified (7 in positive ion mode and 9 in negative ion mode), and they are involved in 15 related metabolic pathways. After oral administration of ASSL, 10 biomarkers were found to be significantly up-regulated and mainly regulated metabolic pathways include unsaturated fatty acid biosynthesis, linoleic acid metabolism, and arachidonic acid metabolism, primary bile acid synthesis, tyrosine metabolism, etc. Our study demonstrated that the ASSL could affect the endogenous metabolites related metabolic mechanism, provides a pharmacological basis of the ASSL for PMOP treatment.

show abstract

“…Notably, under normal conditions, the kidneys continuously excrete uric acid out of the body, and the presence of circulating uric acids in the body is an important determinant of renal impairment (Stamp et al, 2011). In addition to being the routine biomarkers of kidney (Klein et al, 2018; Lu et al, 2018) and liver diseases (Drolz et al, 2018), urates or its related products are also proving to have diagnostic value in other important diseases, such as Parkinson's disease (Cova and Priori, 2018), diabetes (Xie et al, 2018), cardiovascular diseases (Murata et al, 2018), obstructive sleep apnea (Fleming et al, 2018), and bone inflammation (Beyazit and Pek, 2018). Urates or urea derivatives have also shown applicable values in clinical diagnosis of renal diseases (Yang et al, 2018), gastrointestinal and hepatic diseases (Siddiqui et al, 2016), using advanced technologies like self-powered implantable electronic-skin and non-invasive breath test, respectively.…”

Section: Types Of Biomarkersmentioning

confidence: 99%

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

Dhama

Latheef

Dadar

et al. 2019

Front. Mol. Biosci.

221

172

View full text Add to dashboard Cite

Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific databases. Stress levels can be monitored by the quantitative and qualitative measurement of biomarkers. Potential markers of stress include thermal stress markers, such as heat shock proteins (HSPs), innate immune markers, such as Acute Phase Proteins (APPs), oxidative stress markers, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be employed to evaluate these conditions precisely, but with stringent validation and specificity. Considerable scientific advances have been made in the detection, quantitation, and application of these biomarkers. The present review describes the current progress of identifying biomarkers, their prognostic, and therapeutic values.

show abstract

Effects of vitamin B 12 , folate, uric acid, and serum biomarkers of inflammation on bone mineral density in postmenopausal women

Cited by 11 publications

References 40 publications

Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults

Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults

High-Throughput Metabolomics Evaluate the Efficacy of Total Lignans From Acanthophanax Senticosus Stem Against Ovariectomized Osteoporosis Rat

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

Contact Info

Product

Resources

About